Processing Pearl Nacre for Bio-Nanotechnology. Nanotechnology has exciting potential to solve major health challenges of the 21st century. The proposed research focuses on developing health care products, derived from a renewable waste stream resource from the pearling industry, en route to establishing products to benefit the rural community, and beyond. The processed pearl nacre provides the possibility of alleviating problems associated with neurotrauma following injury, and for skin regenera ....Processing Pearl Nacre for Bio-Nanotechnology. Nanotechnology has exciting potential to solve major health challenges of the 21st century. The proposed research focuses on developing health care products, derived from a renewable waste stream resource from the pearling industry, en route to establishing products to benefit the rural community, and beyond. The processed pearl nacre provides the possibility of alleviating problems associated with neurotrauma following injury, and for skin regeneration following burns. The recently established powerful multidisciplinary research team in partnership with Pearl Technology combines expertise in chemical processing, nanotechnology, biochemistry, neuroscience and tissue engineering, also providing a basis for quality research training.Read moreRead less
Ultrathin Gold Nanocrystal Conductors for Wearable Epidermal Biofuel Cells. This project aims to fabricate ultrathin, soft yet stretchable gold nanocrystal conductors to push the thickness limit of next-generation soft bioelectrodes for fabrication of wearable epidermal biofuel cells. This will generate new knowledge and patentable technologies related to design/fabrication of soft nanocrystal conductors, bioanode and biocathode, which require to be thin, soft, conductive and biocompatible. Expe ....Ultrathin Gold Nanocrystal Conductors for Wearable Epidermal Biofuel Cells. This project aims to fabricate ultrathin, soft yet stretchable gold nanocrystal conductors to push the thickness limit of next-generation soft bioelectrodes for fabrication of wearable epidermal biofuel cells. This will generate new knowledge and patentable technologies related to design/fabrication of soft nanocrystal conductors, bioanode and biocathode, which require to be thin, soft, conductive and biocompatible. Expected outcomes of this project include enhanced national capacity in disruptive wearable bioelectronics, strengthening international collaborations, unskilled workforce training, as well as advancement of Australian knowledge base in the fields of nanotechnology, materials science, energy, biosensors and bioelectronics.Read moreRead less
Engineering layered double hydroxide nanoparticles toward an efficient targeted clinical delivery system. This project will develop a more effective drug delivery system using clay nanoparticles and biofriendly serum proteins. Outcomes from this project will provide a tremendous opportunity for potent therapies of cancers, vasculature and neuronal diseases, and place Australia at the forefront of nanotechnology drug delivery research.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100146
Funder
Australian Research Council
Funding Amount
$800,000.00
Summary
Ultra high vacuum scanning probe microscope facility. Ultra high-vacuum scanning tunneling microscopy underpins advances in the understanding of novel materials for electronics, engineering and medical applications, including thin-films, nanostructures, advanced semiconductors, nanostructured (organic or inorganic) conductors, and nanoscale interfaces (heteronanostructures). It is a core technique underpinning the new Superscience agenda in Future Technologies. A number of present and future re ....Ultra high vacuum scanning probe microscope facility. Ultra high-vacuum scanning tunneling microscopy underpins advances in the understanding of novel materials for electronics, engineering and medical applications, including thin-films, nanostructures, advanced semiconductors, nanostructured (organic or inorganic) conductors, and nanoscale interfaces (heteronanostructures). It is a core technique underpinning the new Superscience agenda in Future Technologies. A number of present and future research fields will benefit from the presence of this instrument, which will enhance Australia's competitiveness in nanotechnology research and development. Training of PhD and graduate students in this area is essential to exploit the potentiality of nanotechnology for the future benefit of Australia.Read moreRead less
Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principl ....Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principles as macroscopic machines. Comparing the artificial motor with biological motors will provide insight into the workings of natural motors. This project should lead to molecular motors for nanobiotechnology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101666
Funder
Australian Research Council
Funding Amount
$395,588.00
Summary
Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properti ....Engineering nanoparticles with enhanced adhesion at the nano-bio interfaces. This project aims to develop a next-generation adhesive nanoparticle platform through in-depth understandings of nanoparticle interactions with bio-interfaces. This project expects to generate new knowledge in the multidisciplinary research field at nano-bio-interfaces by using a recently developed nano-colloidal probe technology, instructing the rational design of nanoparticles with enhanced interface adhesive properties. Expected outcomes include a family of adhesive nanoparticles designed for nanopesticide and animal feed applications, with the potential to deliver valuable intellectual property of commercial interest and economic benefit through technology advancement.Read moreRead less
Organically-Capped Copper Nanowires for Soft Electronic Skin Sensors. Soft skin-like electronics can enable applications that are impossible to achieve with today's rigid circuit board technologies. However, it is difficult to realise such future soft electronics with traditional materials and conventional manufacturing methodologies. This project aims to synthesise novel organically-capped copper nanowires as electronic inks (e-inks) for developing cost-effective, soft, stretchable conductor (e ....Organically-Capped Copper Nanowires for Soft Electronic Skin Sensors. Soft skin-like electronics can enable applications that are impossible to achieve with today's rigid circuit board technologies. However, it is difficult to realise such future soft electronics with traditional materials and conventional manufacturing methodologies. This project aims to synthesise novel organically-capped copper nanowires as electronic inks (e-inks) for developing cost-effective, soft, stretchable conductor (e-skin) sensors, which are wearable for monitoring blood pulses, body motions and hand gestures in real-time and in situ. This is expected to advance our knowledge in nanotechnology and generate patentable technologies in soft e-skin sensors, and to bring significant scientific and economic gains to Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100488
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Cellular dynamics of nanoengineered particles. Nanotechnology has the capacity to drive a new wave of biological innovation through engineering materials at the nanoscale. This project will advance understanding of how nanoengineered materials interact with biological systems to enable the development of nanomaterials for future translational research.
Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in c ....Single molecule sensing on nanopillars: Reading complex molecular circuits. This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in cellular pathways. Expected outcomes include a universal technology platform to detect single molecules in single cells, with potential to deliver valuable intellectual property of commercial interest and economic benefit through technological advancements.Read moreRead less
Next generation hybrid nanomaterials: bispecific antibody-targeted polymers. This project aims to develop and optimise a novel platform technology that will assist in the development of hybrid materials consisting of nanomaterials and biomolecules, which form the basis of many commercial diagnostic devices. A novel antibody, MIL38, will provide the test bed for the technology, which will aim to deliver a platform that is stable under physiological conditions and that enables facile conjugation o ....Next generation hybrid nanomaterials: bispecific antibody-targeted polymers. This project aims to develop and optimise a novel platform technology that will assist in the development of hybrid materials consisting of nanomaterials and biomolecules, which form the basis of many commercial diagnostic devices. A novel antibody, MIL38, will provide the test bed for the technology, which will aim to deliver a platform that is stable under physiological conditions and that enables facile conjugation of nanomaterials with antibodies. This project has the potential to rapidly improve the ligation process between synthetic nanomaterials and biologics, leading to more efficient synthesis of targeted diagnostics. This would provide a significant commercial advantage for any nanomaterials developed for the field, and specifically for this project, expedite translation of MIL38.Read moreRead less