Dynamic Microcages for Cells: Advanced Tools to Interrogate Cell Mechanics. This project aims to develop a suite of movable micro/nanostructures with integrated mechanical and biological sensors, which will be interfaced with cells to investigate how those cells respond to their surrounding physical environment. Expected outcomes are new technologies in micro/nanofabrication, sensing, and advanced imaging, and deep understanding of the biological processes that control tissue formation and repai ....Dynamic Microcages for Cells: Advanced Tools to Interrogate Cell Mechanics. This project aims to develop a suite of movable micro/nanostructures with integrated mechanical and biological sensors, which will be interfaced with cells to investigate how those cells respond to their surrounding physical environment. Expected outcomes are new technologies in micro/nanofabrication, sensing, and advanced imaging, and deep understanding of the biological processes that control tissue formation and repair. These outcomes would impact how 3D microsystems are developed and applied, informing the design of advanced in-vitro cell culture systems. Significant benefits are expected in 3D nano-microengineering, and in generating new knowledge underpinning future advances in stem cell and tissue engineering technologies.Read moreRead less
Micro/nano smart surfaces to unlock the potential of multipotent stem cells. This project aims to determine the interplay of micro/nanostructures on stem cell mechanotransduction and to control the cellular environment. It is expected that this will expand our knowledge on how to control stem cell fate. Expected outcomes are novel scalable technologies for micro/nanostructures and smart surfaces, controlled stem-cell expansion and differentiation, and the creation of a library of protein express ....Micro/nano smart surfaces to unlock the potential of multipotent stem cells. This project aims to determine the interplay of micro/nanostructures on stem cell mechanotransduction and to control the cellular environment. It is expected that this will expand our knowledge on how to control stem cell fate. Expected outcomes are novel scalable technologies for micro/nanostructures and smart surfaces, controlled stem-cell expansion and differentiation, and the creation of a library of protein expression based on the cell interactions. These outcomes will provide critical information required for the future development of instructive biomaterials to drive stem cell expansion and tissue-regeneration. Those materials should benefit the future development of efficient and cost-effective regenerative medicine solutions.Read moreRead less