Intelligent nanoparticles: Interactive tools to decode brain activity. This project aims to use nanoparticles and integrated nanoparticle devices to unravel causal relationships between molecular events and high-level brain activity. These devices, capable of real-time sensing and adaptive responses, could expose previously unmeasurable cellular events and establish their physiological effects. This is expected to reveal the complex dynamics in the living brain and advance neuroscience and analy ....Intelligent nanoparticles: Interactive tools to decode brain activity. This project aims to use nanoparticles and integrated nanoparticle devices to unravel causal relationships between molecular events and high-level brain activity. These devices, capable of real-time sensing and adaptive responses, could expose previously unmeasurable cellular events and establish their physiological effects. This is expected to reveal the complex dynamics in the living brain and advance neuroscience and analytical chemistry.Read moreRead less
Artificially building the bacterial flagellar motor. This project will allow us to learn how nature’s most sophisticated rotary motor works and how to build these artificially, establishing a new field of research into man-made biological machines. This has potential applications for the emerging field of nanotechnology to make nanometre-scale devices that are powered by efficient biological machines.
Discovery Early Career Researcher Award - Grant ID: DE180100206
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Intelligently linking nanoscience to neuroscience with glycan biology. This project aims to provide a comprehensive description of the unique cell-surface glycan expression on inflamed neurons, astrocytes, microglia and oligodendrocytes. This project will use glycan profiling data to engineer luminescent nanoparticles with superior neuroimaging qualities for cell type-specific in vivo targeting and drug delivery in the central nervous system. The project outcomes are expected to improve our fund ....Intelligently linking nanoscience to neuroscience with glycan biology. This project aims to provide a comprehensive description of the unique cell-surface glycan expression on inflamed neurons, astrocytes, microglia and oligodendrocytes. This project will use glycan profiling data to engineer luminescent nanoparticles with superior neuroimaging qualities for cell type-specific in vivo targeting and drug delivery in the central nervous system. The project outcomes are expected to improve our fundamental understanding of neurobiological cell-surfaces.Read moreRead less
Bacterial detection and infection control using tethered membranes. This project will develop a rapid diagnostic tool to detect live bacteria, which will subsequently reduce risk of infection, increase efficiencies in patient care and hospital management, and produce savings in health care budgets. It also has the potential to save lives through addressing the serious and growing problem of antibiotic resistance.
Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevi ....Harnessing the bioactivity of proteins and polypeptides: understanding and controlling adsorption processes to optimise linker free immobilisation. This project will use physical techniques and simulations to understand the interactions of biomolecules and plasma activated surfaces, allowing control of the biomolecule layer composition, orientation and conformation. This control, together with the ability of these surfaces to "lock-in" the optimised layer, will create a new generation of biodevices.Read moreRead less
Processing Pearl Nacre for Bio-Nanotechnology. Nanotechnology has exciting potential to solve major health challenges of the 21st century. The proposed research focuses on developing health care products, derived from a renewable waste stream resource from the pearling industry, en route to establishing products to benefit the rural community, and beyond. The processed pearl nacre provides the possibility of alleviating problems associated with neurotrauma following injury, and for skin regenera ....Processing Pearl Nacre for Bio-Nanotechnology. Nanotechnology has exciting potential to solve major health challenges of the 21st century. The proposed research focuses on developing health care products, derived from a renewable waste stream resource from the pearling industry, en route to establishing products to benefit the rural community, and beyond. The processed pearl nacre provides the possibility of alleviating problems associated with neurotrauma following injury, and for skin regeneration following burns. The recently established powerful multidisciplinary research team in partnership with Pearl Technology combines expertise in chemical processing, nanotechnology, biochemistry, neuroscience and tissue engineering, also providing a basis for quality research training.Read moreRead less
Ultrathin Gold Nanocrystal Conductors for Wearable Epidermal Biofuel Cells. This project aims to fabricate ultrathin, soft yet stretchable gold nanocrystal conductors to push the thickness limit of next-generation soft bioelectrodes for fabrication of wearable epidermal biofuel cells. This will generate new knowledge and patentable technologies related to design/fabrication of soft nanocrystal conductors, bioanode and biocathode, which require to be thin, soft, conductive and biocompatible. Expe ....Ultrathin Gold Nanocrystal Conductors for Wearable Epidermal Biofuel Cells. This project aims to fabricate ultrathin, soft yet stretchable gold nanocrystal conductors to push the thickness limit of next-generation soft bioelectrodes for fabrication of wearable epidermal biofuel cells. This will generate new knowledge and patentable technologies related to design/fabrication of soft nanocrystal conductors, bioanode and biocathode, which require to be thin, soft, conductive and biocompatible. Expected outcomes of this project include enhanced national capacity in disruptive wearable bioelectronics, strengthening international collaborations, unskilled workforce training, as well as advancement of Australian knowledge base in the fields of nanotechnology, materials science, energy, biosensors and bioelectronics.Read moreRead less
Engineering layered double hydroxide nanoparticles toward an efficient targeted clinical delivery system. This project will develop a more effective drug delivery system using clay nanoparticles and biofriendly serum proteins. Outcomes from this project will provide a tremendous opportunity for potent therapies of cancers, vasculature and neuronal diseases, and place Australia at the forefront of nanotechnology drug delivery research.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100146
Funder
Australian Research Council
Funding Amount
$800,000.00
Summary
Ultra high vacuum scanning probe microscope facility. Ultra high-vacuum scanning tunneling microscopy underpins advances in the understanding of novel materials for electronics, engineering and medical applications, including thin-films, nanostructures, advanced semiconductors, nanostructured (organic or inorganic) conductors, and nanoscale interfaces (heteronanostructures). It is a core technique underpinning the new Superscience agenda in Future Technologies. A number of present and future re ....Ultra high vacuum scanning probe microscope facility. Ultra high-vacuum scanning tunneling microscopy underpins advances in the understanding of novel materials for electronics, engineering and medical applications, including thin-films, nanostructures, advanced semiconductors, nanostructured (organic or inorganic) conductors, and nanoscale interfaces (heteronanostructures). It is a core technique underpinning the new Superscience agenda in Future Technologies. A number of present and future research fields will benefit from the presence of this instrument, which will enhance Australia's competitiveness in nanotechnology research and development. Training of PhD and graduate students in this area is essential to exploit the potentiality of nanotechnology for the future benefit of Australia.Read moreRead less