Splice Correction As A Treatment For Rare Diseases
Funder
National Health and Medical Research Council
Funding Amount
$824,316.00
Summary
We propose that a strategy of bringing effective and personalised treatments to amenable patients with rare genetic diseases, though ambitious, is readily achievable and opportune. Importantly, a consensus approach will facilitate expediting potentially curative treatments for many patients with rare diseases that would be unlikely to be commercially viable if considered individually.
Industrial Transformation Training Centres - Grant ID: IC170100035
Funder
Australian Research Council
Funding Amount
$4,743,710.00
Summary
ARC Training Centre for Innovation in Biomedical Imaging Technology. The ARC Training Centre for Innovation in Biomedical Imaging Technology expects to train 20 industry-ready innovation scientists who will undertake industry-driven research in the development and application of novel diagnostics, therapeutics and theranostics. They will inform changes in regulatory policy that support industry growth. The Centre will build multidisciplinary links between researchers and within industry to devel ....ARC Training Centre for Innovation in Biomedical Imaging Technology. The ARC Training Centre for Innovation in Biomedical Imaging Technology expects to train 20 industry-ready innovation scientists who will undertake industry-driven research in the development and application of novel diagnostics, therapeutics and theranostics. They will inform changes in regulatory policy that support industry growth. The Centre will build multidisciplinary links between researchers and within industry to develop ‘smart’ probes and ‘smart’ scanning, harnessing the digital revolution for better, cost effective diagnostic imaging and improved health outcomes.Read moreRead less
Pushing the Boundaries of Multi-modal Biospectroscopic Microscopies. In order to understand the fundamentals of life processes, diseases, and their treatments, it is essential to probe fundamental changes in molecular processes in cells, tissues and whole organisms. Much of our understanding of these processes has involved the introduction of chemical probes for biospectroscopy, but these have inherent problems because the probe can often change the biochemistry that is being probed. This projec ....Pushing the Boundaries of Multi-modal Biospectroscopic Microscopies. In order to understand the fundamentals of life processes, diseases, and their treatments, it is essential to probe fundamental changes in molecular processes in cells, tissues and whole organisms. Much of our understanding of these processes has involved the introduction of chemical probes for biospectroscopy, but these have inherent problems because the probe can often change the biochemistry that is being probed. This project will push the boundaries of a variety of micro and nano "probe-free" microscopies to provide fundamental insights into these life processes, which could ultimately lead to improvements in the diagnosis, prevention and treatment of diseases.Read moreRead less
Development of disulphide-rich peptides for drug design. Peptides are an outstanding source of potential drug leads. This project seeks to build on earlier breakthroughs by developing stable, peptide-based drugs to combat cancer and autoimmune diseases. The peptides, derived from natural sources, are anticipated to provide drug leads that can ultimately lead to treatments for these diseases.
Nanoparticle formulations for DNA-targeted radiotherapy and imaging: combinations with chromatin-modifying compounds. This project will develop a new approach for treating and imaging cancer using nanoparticles which target specific cells for cancer therapy and diagnostic imaging. The nanoparticles will be combined with compounds that alter the architecture of DNA to make therapy more effective and to improve the safety of imaging.
The Australia Fellowship will enable Prof Good to pursue the development of vaccines for two major pathogens – malaria and group A streptococcus (GAS). Both research programs are entering exciting phases as we move into Phase I clinical trials. At the same time, the Fellowship will enable us to explore the development of the next generation vaccine candidates for these diseases. Malaria is responsible for approximately 1 million deaths per year, mainly of children under 5 years of age, while dis ....The Australia Fellowship will enable Prof Good to pursue the development of vaccines for two major pathogens – malaria and group A streptococcus (GAS). Both research programs are entering exciting phases as we move into Phase I clinical trials. At the same time, the Fellowship will enable us to explore the development of the next generation vaccine candidates for these diseases. Malaria is responsible for approximately 1 million deaths per year, mainly of children under 5 years of age, while diseases caused by group A streptococcus (such as rheumatic heart disease [RHD] and RHD-related stroke) are responsible for at least 500,000 deaths per year. Australia’s Indigenous population suffer the highest documented rate of RHD in the world. We have strong international support and collaboration for these vaccine research programs and have approached the US FDA for a license to conduct the trial for a GAS vaccine and will soon approach them for a licence to undertake the malaria vaccine trial.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100010
Funder
Australian Research Council
Funding Amount
$720,000.00
Summary
A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the ....A 5-D Correlative Imaging Platform: Combining the strengths of light and electron microscopy. This will be Australia's first dedicated five-dimensional multiphoton-microscopy platform, allowing observation of dynamic structures across different length and time scales under controlled temperatures, followed by high-resolution electron microscopy studies on the same samples. This platform will provide a unique characterisation tool to Australia's top-flight investigators, and so contribute to the nation's research priorities. It will enable: fundamental studies of cancer, neural diseases and immune disorders; the development of frontier technologies, such as smart nanomaterials, biosensors and targeted drug delivery; and applied research to help plants and soils adapt to climate variability, and to increase sustainable use of water.Read moreRead less
Evaluation Of The Safety Of Lead Compounds For Allergic Asthma
Funder
National Health and Medical Research Council
Funding Amount
$310,568.00
Summary
Asthma is one of the most common chronic respiratory diseases in developed countries and is typically treated with corticosteroids which provide symptomatic relief and coarse non-specific treatment of the underlying disease. We are pursuing innovative therapies by targeting a different enzyme, HPGD2S, involved in the inflammatory mechanisms of asthma. We have developed potent, anti-inflammatory drug candidates and aim to profile the safety of these compounds before entering clinical studies.
Roles of Metal Complexes in Carbohydrate Metabolism – Anti-Diabetic Drugs. This project aims to study the biological chemistry of chromium, vanadium, molybdenum and tungsten in glucose/fructose metabolism. Metal supplements are consumed widely for purported fat reduction and anti-diabetic activities but pose many questions about their efficacy, safety and essentiality. The project plans to explore evidence for an essential role for vanadium and molybdenum in carbohydrate metabolism and to invest ....Roles of Metal Complexes in Carbohydrate Metabolism – Anti-Diabetic Drugs. This project aims to study the biological chemistry of chromium, vanadium, molybdenum and tungsten in glucose/fructose metabolism. Metal supplements are consumed widely for purported fat reduction and anti-diabetic activities but pose many questions about their efficacy, safety and essentiality. The project plans to explore evidence for an essential role for vanadium and molybdenum in carbohydrate metabolism and to investigate the transport, uptake and biological activities of the above metals. These fundamental chemical and biochemical studies could provide the basis of future research into improved prevention and treatment methods to reduce the incidence of type 2 diabetes.Read moreRead less
Development of effective peptide-based drugs. There is huge interest in the development of bioactive peptides and proteins for the treatment of a wide range of diseases. The aim of this research project is to develop potent and effective peptide-based drugs that are able to resist the body's natural degradation pathways so that they can reach their biological target and act as effective drugs.