A novel precision-engineered microfluidic chip for wear particle research. This project aims to develop 1- novel protocols to generate clinically-relevant wear particles from spinal implants in-vitro and 2- a technological framework for the fabrication of a novel microfluidic 3D spinal implant-on-a-chip with tailored mechanical, material and biological properties. This will provide a cost-effective tool, currently unavailable, that allows investigation into the impact of wear particles on health ....A novel precision-engineered microfluidic chip for wear particle research. This project aims to develop 1- novel protocols to generate clinically-relevant wear particles from spinal implants in-vitro and 2- a technological framework for the fabrication of a novel microfluidic 3D spinal implant-on-a-chip with tailored mechanical, material and biological properties. This will provide a cost-effective tool, currently unavailable, that allows investigation into the impact of wear particles on healthy spinal disc cells. We expect our technological framework to become an invaluable tool for biomedical engineers, biologists, and bio-engineers to work together and generate clinically relevant in-vitro data that supports optimisation for spinal implant design, fabrication, and safety. Read moreRead less
Diamond Microneedles for Minimally Invasive Blood Collection. Blood sampling is a routine procedure for medical purposes to determine the physiological and biochemical status of patients. The aim of this project is to develop a reliable microneedle array for a blood collection procedures. Micro-scale needles for low-volume perforated blood samples are highly desirable due to its minimal invasiveness and painlessness. The miniaturization of sampling platforms driven by microneedles has the poten ....Diamond Microneedles for Minimally Invasive Blood Collection. Blood sampling is a routine procedure for medical purposes to determine the physiological and biochemical status of patients. The aim of this project is to develop a reliable microneedle array for a blood collection procedures. Micro-scale needles for low-volume perforated blood samples are highly desirable due to its minimal invasiveness and painlessness. The miniaturization of sampling platforms driven by microneedles has the potential to shift disease diagnosis and monitoring closer to the point of care. Expected outcomes include the development of synthetic diamond-based microneedles for the potential to greatly benefit society through improved and affordable healthcare and the development of new high-tech industries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100692
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Multiphysics inertial microfluidics: from fundamentals to applications. Separation of particles and particularly cells is an indispensable process in disease diagnostics, chemical/biological assays and food/chemical industries. This project aims to study the interplay between inertial fluid flow, electricity, and magnetism in microscale for particle separation. The project is expected to establish the fundamental theory underpinning the development of the proposed advanced separation technology. ....Multiphysics inertial microfluidics: from fundamentals to applications. Separation of particles and particularly cells is an indispensable process in disease diagnostics, chemical/biological assays and food/chemical industries. This project aims to study the interplay between inertial fluid flow, electricity, and magnetism in microscale for particle separation. The project is expected to establish the fundamental theory underpinning the development of the proposed advanced separation technology. This disruptive technology is expected to enable the unique, high-performance and high-throughput separation of particles such as cells. The technology will potentially benefit the biomedical and pharmaceutical industries, providing economic opportunities and maintaining high-quality healthcare for Australia.Read moreRead less