A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interac ....A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering. Read moreRead less
Modular microfluidic platform for mimicking multi-organ system interactions. This project aims to develop a novel, modular microfluidic platform that overcomes current limitations of integrated systems in synchronising multi-tissue culture, imaging and operational complexity. Understanding multi-organ systemic crosstalk in human health and diseases demands dynamic culture systems that can mimic such interactions. This project will deliver a first-in-class platform technology and establish intern ....Modular microfluidic platform for mimicking multi-organ system interactions. This project aims to develop a novel, modular microfluidic platform that overcomes current limitations of integrated systems in synchronising multi-tissue culture, imaging and operational complexity. Understanding multi-organ systemic crosstalk in human health and diseases demands dynamic culture systems that can mimic such interactions. This project will deliver a first-in-class platform technology and establish international and disciplinary collaborations to develop different tissue and engineering modules relevant to applications in systemic nanotoxicology, drug bioactivation and chronic diseases. This will provide the cornerstone technology to develop a new generation of disease models and therapeutics targeting interaction dysfunctions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100168
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
Integrated Functional Printing Facility for Advanced Material Technologies. The project aims to develop Australia’s first fully integrated small-scale and agile prototyping facility for printing. This facility will provide critical infrastructure to deposit a wide range of advanced materials with unprecedented precision & process flexibility allowing realistic form, configuration and device-ready formats with minimal usage of functional ink. Using this unique facility, researchers will be able t ....Integrated Functional Printing Facility for Advanced Material Technologies. The project aims to develop Australia’s first fully integrated small-scale and agile prototyping facility for printing. This facility will provide critical infrastructure to deposit a wide range of advanced materials with unprecedented precision & process flexibility allowing realistic form, configuration and device-ready formats with minimal usage of functional ink. Using this unique facility, researchers will be able to assess integration of novel functional materials in a wide range of devices and applications, including critical components of affordable healthcare diagnostic devices, advanced security features in banknotes, integrated RFID tracking systems, high performance solar cells and separation membranes. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101733
Funder
Australian Research Council
Funding Amount
$400,661.00
Summary
3D printing of multi-level porosity glass. This project aims to explore the fundamentals of 3D printing glass and multi-level porosity structures. 3D printing of plastics and metals fails to realise low-cost, robust, transparent, and biocompatible devices. The advent of glass and ceramic 3D printing can overcome these limitations. Moreover, multi-level porosity structures are becoming vital to the advancement of various fields, such as energy, health, and environmental. Expected outcomes of the ....3D printing of multi-level porosity glass. This project aims to explore the fundamentals of 3D printing glass and multi-level porosity structures. 3D printing of plastics and metals fails to realise low-cost, robust, transparent, and biocompatible devices. The advent of glass and ceramic 3D printing can overcome these limitations. Moreover, multi-level porosity structures are becoming vital to the advancement of various fields, such as energy, health, and environmental. Expected outcomes of the project would include the development of more sustainable glass and ceramic manufacturing procedure and new high-performance multi-level porosity devices. The project should provide significant benefits by addressing four science and research priorities of Australia.Read moreRead less
Mechanisms and Platforms for Acoustomicrofluidic Intracellular Delivery . This project aims to advance a novel platform to facilitate faster and more effective molecular transport into cells as a means for enhancing cell engineering. Besides elucidating the fundamental physicochemical and biological mechanisms underpinning this new method of intracellular transport through a combination of theoretical modelling and advanced imaging and neutron diffraction, the project aims to show the scalabilit ....Mechanisms and Platforms for Acoustomicrofluidic Intracellular Delivery . This project aims to advance a novel platform to facilitate faster and more effective molecular transport into cells as a means for enhancing cell engineering. Besides elucidating the fundamental physicochemical and biological mechanisms underpinning this new method of intracellular transport through a combination of theoretical modelling and advanced imaging and neutron diffraction, the project aims to show the scalability of the technology for high throughput processing to handle the large cell numbers typically required for doses to be effective in practice. Given recent breakthroughs in cell therapies, it is expected that translation of the technology in the longer term will improve treatments for cancer and other infectious diseases.Read moreRead less