Early evolutionary origins of mechanosensory transduction: structure, function and phylogenetic studies of the family of mechanosensitive channels in cell-walled organisms. The proposed project is based on the recent progress the applicants have made by (i) identifying a novel family of mechanosensitive (MS) channels in cell-walled organisms, which include Archaea and Bacteria (prokaryotes), as well as fungi and plants (eukaryotes), and (ii) determining basic aspects of the structural dynamics ....Early evolutionary origins of mechanosensory transduction: structure, function and phylogenetic studies of the family of mechanosensitive channels in cell-walled organisms. The proposed project is based on the recent progress the applicants have made by (i) identifying a novel family of mechanosensitive (MS) channels in cell-walled organisms, which include Archaea and Bacteria (prokaryotes), as well as fungi and plants (eukaryotes), and (ii) determining basic aspects of the structural dynamics of MscL, the prototype MS channel, using electronparamagnetic resonance spectroscopy and molecular dynamics simulations in combination with the patch clamp technique. The aim of the project is to elucidate the molecular principles underlying the function of MS channels, which is of fundamental importance for understanding of the biophysics and physiology of mechanosensory transduction throughout the biological world.Read moreRead less
Novel Technology for Improving Disinfection Outcomes in Regional and Remote Drinking Water Distribution Systems. Climate shifts have led to water supply shortages in many areas of Australia, both in rural and remote regions and in cities. To ease water shortages, transportation of water over long distances is becoming increasingly necessary. A major impediment to transfer of water through long mains is management of the disinfectant: most disinfectants decay too rapidly, leaving consumers at ris ....Novel Technology for Improving Disinfection Outcomes in Regional and Remote Drinking Water Distribution Systems. Climate shifts have led to water supply shortages in many areas of Australia, both in rural and remote regions and in cities. To ease water shortages, transportation of water over long distances is becoming increasingly necessary. A major impediment to transfer of water through long mains is management of the disinfectant: most disinfectants decay too rapidly, leaving consumers at risk of pathogen exposure. Chloramination, the most viable disinfection technology for this purpose, suffers from a process called nitrification which accelerates disinfectant decay. In this project, we are developing an innovative, patented process to prevent nitrification, which will allow safe and effective disinfection of water supplies in long pipelines.Read moreRead less
An integrated genomics approach to improve our understanding of the biology of genital campylobacteriosis in beef cattle. Beef is Australia's most valuable agricultural export estimated at $9.6B annually and this industry accounts for one-third of full time employment in regional communities. Currently, unknown causes of reproductive losses in cattle in Northern Australian cost producers approximately $15M per annum. Bovine genital campylobacteriosis is one of the major risk factors associated w ....An integrated genomics approach to improve our understanding of the biology of genital campylobacteriosis in beef cattle. Beef is Australia's most valuable agricultural export estimated at $9.6B annually and this industry accounts for one-third of full time employment in regional communities. Currently, unknown causes of reproductive losses in cattle in Northern Australian cost producers approximately $15M per annum. Bovine genital campylobacteriosis is one of the major risk factors associated with this high cost due to the inability to accurately diagnose the disease. This research will integrate genomics and bioinformatics with infection and vaccination models to improve our understanding of the biology of the disease to develop appropriate control strategies securing Australia's beef industry.Read moreRead less