Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce ....Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce knowledge of broad relevance to modern life sciences and its applications in medicine and biotechnology. Finally, a better understanding of yeast cellular biology is of benefit to the food and biotechnology sector of industry.Read moreRead less
The evolution and maintenance of specificity, mutualism and diversity in plant-soil microbe interactions. This research will significantly advance knowledge regarding the evolution of mutualisms between plant and soil microbes. Results will provide valuable data on the importance of below-ground microbial community structure to growth and productivity of an ecologically important component of the Australian flora (Acacia spp.), and contribute to the development of best ecosystem restoration prac ....The evolution and maintenance of specificity, mutualism and diversity in plant-soil microbe interactions. This research will significantly advance knowledge regarding the evolution of mutualisms between plant and soil microbes. Results will provide valuable data on the importance of below-ground microbial community structure to growth and productivity of an ecologically important component of the Australian flora (Acacia spp.), and contribute to the development of best ecosystem restoration practices. Furthermore, it will see the continued development of the Acacia-rhizobia system as a world-class model for exploring interactions between perennial legumes and microbial symbionts. The research also investigates the adaptability and potential for rapid evolution of critical elements of the soil microflora to environmental change.Read moreRead less
A systems approach to dissect the pathogenicity and host specificity of the Fusarium wilt pathogen, Fusarium oxysporum. The pathogenic fungus Fusarium oxysporum causes wilt disease in many plant species, including many that are important for Australian agriculture. Developing environmentally friendly disease protection strategies against this pathogen requires a clear understanding of infection strategies used by the fungus to invade its host. This project, along with a parallel project in host ....A systems approach to dissect the pathogenicity and host specificity of the Fusarium wilt pathogen, Fusarium oxysporum. The pathogenic fungus Fusarium oxysporum causes wilt disease in many plant species, including many that are important for Australian agriculture. Developing environmentally friendly disease protection strategies against this pathogen requires a clear understanding of infection strategies used by the fungus to invade its host. This project, along with a parallel project in host resistance mechanisms, will provide the basis for development of a world leading platform in mechanisms of fungal pathogenicity and virulence and plant disease resistance/susceptibility. Application of the knowledge gained in this project to other host-pathogen interactions will thereby provide opportunities for improved crop protection and biosecurity.Read moreRead less