Linking individual traits, the gut microbiome and parasite load in wildlife. This project aims to apply principles of community ecology to the gut microbiome of an urban exploiter – the common brushtail possum - to reveal how animal traits influence individual variation in the load of gut parasites that cause disease in both humans and wildlife. By combining assays defining the behavioural and physiological states of individuals with sophisticated analyses of their gut microbiome, our project wi ....Linking individual traits, the gut microbiome and parasite load in wildlife. This project aims to apply principles of community ecology to the gut microbiome of an urban exploiter – the common brushtail possum - to reveal how animal traits influence individual variation in the load of gut parasites that cause disease in both humans and wildlife. By combining assays defining the behavioural and physiological states of individuals with sophisticated analyses of their gut microbiome, our project will provide a new, yet crucial, perspective on how and why diseases spread. Our discoveries will help understand and manage the burden of infectious diseases from parasites in and beyond our cities and across the human-wildlife interface; essential for improving human and wildlife health in an increasingly urbanised Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100032
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
A ToF-SIMS facility for elemental and isotopic imaging of ultra-fine features for researchers in east Australia. A time of flight secondary ion mass spectrometer facility for elemental and isotopic imaging of ultra-fine features: Microbiology has long been an area of strength in Australian science. With recent technological advances microbiology has entered a new golden age unveiling an extraordinary level of diversity and the central role of microbes in global biogeochemistry. The 'omics' era i ....A ToF-SIMS facility for elemental and isotopic imaging of ultra-fine features for researchers in east Australia. A time of flight secondary ion mass spectrometer facility for elemental and isotopic imaging of ultra-fine features: Microbiology has long been an area of strength in Australian science. With recent technological advances microbiology has entered a new golden age unveiling an extraordinary level of diversity and the central role of microbes in global biogeochemistry. The 'omics' era is generating endless hypotheses regarding geochemical processes carried out by microbes and this necessitates the application of advanced technologies to generate empirical support. Time of flight secondary ion mass spectrometry has emerged as a key tool to unravel elemental cycling carried out by microorganisms in mixed species communities in contexts ranging from terrestrial to marine ecology and from groundwater bioremediation to biogas production biotechnologies.Read moreRead less
Mapping and Modelling the Ocean's Unseen Biodiversity. From the reef to the rainforest, Australia is famous for its unique biodiversity. Less well known is that Australia's coastline is predicted to be a global hotspot for biodiversity in marine microbes, the unseen life forces that maintain ocean health and productivity. This project aims to overcome historical technological and logistical hurdles by using cutting-edge sampling, genetic and modelling tools to provide the first models of microbi ....Mapping and Modelling the Ocean's Unseen Biodiversity. From the reef to the rainforest, Australia is famous for its unique biodiversity. Less well known is that Australia's coastline is predicted to be a global hotspot for biodiversity in marine microbes, the unseen life forces that maintain ocean health and productivity. This project aims to overcome historical technological and logistical hurdles by using cutting-edge sampling, genetic and modelling tools to provide the first models of microbial diversity patterns and organismal range in Australian marine systems. This is expected to be a crucial step for understanding the evolutionary and ecological processes that shape contemporary biodiversity.Read moreRead less
E. coli as an indicator of faecal contamination in the Australian context. The goal of this research is to improve our ability to use Escherichia coli as an indicator of water quality by determining the extent to which non-faecal sources of E. coli contribute to coliform counts and to develop a method to differentiate non-faecal E. coli from those that are faecal derived.
Keystone microbes and planktonic guilds in Australia's oceans. This project aims to unveil the ocean’s hidden sentinels, “keystone microbes” that underpin precious ecosystem services, and which can be used to monitor and model changes in ocean function. Marine microbes account for 90 per cent of oceanic biomass and every litre of seawater contains ~20,000 different species, but it is not known which species control ocean health and productivity. This project intends to provide definitive evidenc ....Keystone microbes and planktonic guilds in Australia's oceans. This project aims to unveil the ocean’s hidden sentinels, “keystone microbes” that underpin precious ecosystem services, and which can be used to monitor and model changes in ocean function. Marine microbes account for 90 per cent of oceanic biomass and every litre of seawater contains ~20,000 different species, but it is not known which species control ocean health and productivity. This project intends to provide definitive evidence of these keystones’ cellular level biogeochemical and metabolic capacity. Ultimately, this knowledge is expected to predict the resilience of ocean ecosystems and their response to change. The capacity to predict their dynamics will help provide investment clarity and increase healthy outcomes from activities involving human-ocean interactions such as recreation, food production and tourism.Read moreRead less
Molecular fossils, environmental genomics and the natural history of an Australian salt lake. Increasing salinity of lakes is a critical problem for sustainable water supply in Australia. To comprehend the consequences of human-induced salinization, it is crucial to understand salt lakes at their most fundamental level. This project develops pioneering technologies to elucidate the microbial ecology and geochemistry of salt lakes in unprecedented detail. It will open new pathways to unravel how ....Molecular fossils, environmental genomics and the natural history of an Australian salt lake. Increasing salinity of lakes is a critical problem for sustainable water supply in Australia. To comprehend the consequences of human-induced salinization, it is crucial to understand salt lakes at their most fundamental level. This project develops pioneering technologies to elucidate the microbial ecology and geochemistry of salt lakes in unprecedented detail. It will open new pathways to unravel how microbial ecosystems adapt to increasing salinization, and how they reacted to climate fluctuations in the past. Students will gain multidisciplinary skills in environmental genomics, proteomics and geochemistry, a unique combination that will become decisive for understanding and preserving ecosystems on our continent.Read moreRead less
Australia's ocean microbiome: how the diversity and functionality of microbes influence key oceanographic provinces. Every millilitre of seawater contains millions of microbes that maintain the health of our planet, but their identity and function in Australian waters is undefined. This project will identify the microbes inhabiting Australian marine systems, elucidate the services they provide, and predict how they will be affected by future environmental changes
Incorporating new knowledge of phytoplankton diversity and nutrient utilisation into an ocean-climate model to improve forecasts of ocean function. Phytoplankton drives ocean biogeochemical cycles and regulate Earth’s climate yet are poorly represented in ocean-climate models. This project will use advanced cell sorting and analysis techniques and innovative selection experiments to gain a deeper understanding of phytoplankton diversity and nutrient utilisation under projected climate change. Th ....Incorporating new knowledge of phytoplankton diversity and nutrient utilisation into an ocean-climate model to improve forecasts of ocean function. Phytoplankton drives ocean biogeochemical cycles and regulate Earth’s climate yet are poorly represented in ocean-climate models. This project will use advanced cell sorting and analysis techniques and innovative selection experiments to gain a deeper understanding of phytoplankton diversity and nutrient utilisation under projected climate change. This new knowledge will be used to improve the biological structure of an existing coupled ocean-climate model and reduce key uncertainties in forecasts of ocean function. This research will provide managers and industry with more accurate insight into the effects of ongoing climate change on the delivery of ecosystem services in eastern Australian waters.Read moreRead less
Understanding the koala microbiome: unlocking the secrets of koala health and dietary specialisation, and successful husbandry and translocation. This project aims to discover how the composition and function of koala gastrointestinal microbial communities differ in space and time in response to the varying nutritional quality and chemical composition of koala diets. Using detailed chemical analysis, cutting edge metagenomic and bioinformatic pipelines and powerful approaches to study enzyme fun ....Understanding the koala microbiome: unlocking the secrets of koala health and dietary specialisation, and successful husbandry and translocation. This project aims to discover how the composition and function of koala gastrointestinal microbial communities differ in space and time in response to the varying nutritional quality and chemical composition of koala diets. Using detailed chemical analysis, cutting edge metagenomic and bioinformatic pipelines and powerful approaches to study enzyme functions in the koala’s gut, the investigators aims to reveal the role of microbes in detoxification of plant toxins and degradation of recalcitrant fibre fractions. The outcomes aim to facilitate the use of faecal transplants to improve digestive function for translocated and rehabilitated koalas, enhancing options for koala management and conservation.Read moreRead less
Microbial community stability dynamics to environmental triggers. This project aims to advance our knowledge of the structural/functional dynamics of complex microbial communities by defining stability in response to environmental influences such as nutrient stress, pathogen invasion and antibiotics/chemicals. Using innovative microbial consortia modelling, to identify communities at risk of homeostatic disruption, we will develop and test pre-emptive microbial manipulation strategies for restor ....Microbial community stability dynamics to environmental triggers. This project aims to advance our knowledge of the structural/functional dynamics of complex microbial communities by defining stability in response to environmental influences such as nutrient stress, pathogen invasion and antibiotics/chemicals. Using innovative microbial consortia modelling, to identify communities at risk of homeostatic disruption, we will develop and test pre-emptive microbial manipulation strategies for restoring community stability. This project will yield significant global impact and economic/health benefit for humans and animals.Read moreRead less