The ecological dynamics of secreted bacteriocins and the evolution of multiple bacteriocin production in Escherichia coli. Bacteria produce compounds known as bacteriocins that are toxic to other microorganisms. The success of bacteria as bio-control agents and in probiotic formulations for the control microbial pathogens is, in part, due to bacteriocins. Bacteriocins may also have a role as replacements for traditional antibiotics and as natural food preservatives. The potential usefulness of b ....The ecological dynamics of secreted bacteriocins and the evolution of multiple bacteriocin production in Escherichia coli. Bacteria produce compounds known as bacteriocins that are toxic to other microorganisms. The success of bacteria as bio-control agents and in probiotic formulations for the control microbial pathogens is, in part, due to bacteriocins. Bacteriocins may also have a role as replacements for traditional antibiotics and as natural food preservatives. The potential usefulness of bacteriocins as the active agent in bio-control agents, as antibiotic replacements, as food preservatives, and as part of the repertoire of traits in probiotic formulations requires a sound understanding of the eco-evolutionary dynamics of bacteriocins. Understanding the ecology and evolution of bacteriocins is the goal of the proposed research.Read moreRead less
Mapping and Modelling the Ocean's Unseen Biodiversity. From the reef to the rainforest, Australia is famous for its unique biodiversity. Less well known is that Australia's coastline is predicted to be a global hotspot for biodiversity in marine microbes, the unseen life forces that maintain ocean health and productivity. This project aims to overcome historical technological and logistical hurdles by using cutting-edge sampling, genetic and modelling tools to provide the first models of microbi ....Mapping and Modelling the Ocean's Unseen Biodiversity. From the reef to the rainforest, Australia is famous for its unique biodiversity. Less well known is that Australia's coastline is predicted to be a global hotspot for biodiversity in marine microbes, the unseen life forces that maintain ocean health and productivity. This project aims to overcome historical technological and logistical hurdles by using cutting-edge sampling, genetic and modelling tools to provide the first models of microbial diversity patterns and organismal range in Australian marine systems. This is expected to be a crucial step for understanding the evolutionary and ecological processes that shape contemporary biodiversity.Read moreRead less
Keystone microbes and planktonic guilds in Australia's oceans. This project aims to unveil the ocean’s hidden sentinels, “keystone microbes” that underpin precious ecosystem services, and which can be used to monitor and model changes in ocean function. Marine microbes account for 90 per cent of oceanic biomass and every litre of seawater contains ~20,000 different species, but it is not known which species control ocean health and productivity. This project intends to provide definitive evidenc ....Keystone microbes and planktonic guilds in Australia's oceans. This project aims to unveil the ocean’s hidden sentinels, “keystone microbes” that underpin precious ecosystem services, and which can be used to monitor and model changes in ocean function. Marine microbes account for 90 per cent of oceanic biomass and every litre of seawater contains ~20,000 different species, but it is not known which species control ocean health and productivity. This project intends to provide definitive evidence of these keystones’ cellular level biogeochemical and metabolic capacity. Ultimately, this knowledge is expected to predict the resilience of ocean ecosystems and their response to change. The capacity to predict their dynamics will help provide investment clarity and increase healthy outcomes from activities involving human-ocean interactions such as recreation, food production and tourism.Read moreRead less
The biology of arbovirus virulence and fitness in arthropod and vertebrate hosts in vivo. In Australia, Ross River virus (RRV) represents significant concern to human health. Between 1992-2005 more than 50,000 notifications of RRV infection have been reported. While not fatal, the disease is responsible for morbidity in the community/individual that can have both social and economic costs. The project has several national benefits. It will help elucidate whether there is any association between ....The biology of arbovirus virulence and fitness in arthropod and vertebrate hosts in vivo. In Australia, Ross River virus (RRV) represents significant concern to human health. Between 1992-2005 more than 50,000 notifications of RRV infection have been reported. While not fatal, the disease is responsible for morbidity in the community/individual that can have both social and economic costs. The project has several national benefits. It will help elucidate whether there is any association between RRV strain and increased risk of RRV transmission and/or occurrence of more severe cases of human disease. It will help develop technologies that can lead towards the identification of viral markers, which could provide new avenues in the design of novel antiviral strategies.
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Molecular fossils, environmental genomics and the natural history of an Australian salt lake. Increasing salinity of lakes is a critical problem for sustainable water supply in Australia. To comprehend the consequences of human-induced salinization, it is crucial to understand salt lakes at their most fundamental level. This project develops pioneering technologies to elucidate the microbial ecology and geochemistry of salt lakes in unprecedented detail. It will open new pathways to unravel how ....Molecular fossils, environmental genomics and the natural history of an Australian salt lake. Increasing salinity of lakes is a critical problem for sustainable water supply in Australia. To comprehend the consequences of human-induced salinization, it is crucial to understand salt lakes at their most fundamental level. This project develops pioneering technologies to elucidate the microbial ecology and geochemistry of salt lakes in unprecedented detail. It will open new pathways to unravel how microbial ecosystems adapt to increasing salinization, and how they reacted to climate fluctuations in the past. Students will gain multidisciplinary skills in environmental genomics, proteomics and geochemistry, a unique combination that will become decisive for understanding and preserving ecosystems on our continent.Read moreRead less
Australia's ocean microbiome: how the diversity and functionality of microbes influence key oceanographic provinces. Every millilitre of seawater contains millions of microbes that maintain the health of our planet, but their identity and function in Australian waters is undefined. This project will identify the microbes inhabiting Australian marine systems, elucidate the services they provide, and predict how they will be affected by future environmental changes
Incorporating new knowledge of phytoplankton diversity and nutrient utilisation into an ocean-climate model to improve forecasts of ocean function. Phytoplankton drives ocean biogeochemical cycles and regulate Earth’s climate yet are poorly represented in ocean-climate models. This project will use advanced cell sorting and analysis techniques and innovative selection experiments to gain a deeper understanding of phytoplankton diversity and nutrient utilisation under projected climate change. Th ....Incorporating new knowledge of phytoplankton diversity and nutrient utilisation into an ocean-climate model to improve forecasts of ocean function. Phytoplankton drives ocean biogeochemical cycles and regulate Earth’s climate yet are poorly represented in ocean-climate models. This project will use advanced cell sorting and analysis techniques and innovative selection experiments to gain a deeper understanding of phytoplankton diversity and nutrient utilisation under projected climate change. This new knowledge will be used to improve the biological structure of an existing coupled ocean-climate model and reduce key uncertainties in forecasts of ocean function. This research will provide managers and industry with more accurate insight into the effects of ongoing climate change on the delivery of ecosystem services in eastern Australian waters.Read moreRead less
Determinants of substrate preferences and environmental applications of the copper membrane monooxygenases. The project aims to improve sustainability of environmental problems related to methane emissions, nitrogen cycling and pollution. We are developing tools targeting microbial genes correlated to all these issues. Data from these tests provides the information needed for monitoring environmental health and development of sustainable solutions.