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Venom-derived blood-brain-barrier shuttles. This project aims to discover new venom peptides capable of crossing the blood-brain barrier and to develop non-toxic peptide-based brain delivery systems. It addresses long-standing challenges and knowledge gaps in the delivery of macromolecules across biological barriers. Expected outcomes include an improved understanding of the strategies nature exploits to reach targets in the brain, mechanistic pathways to cross biological membranes, and innovati ....Venom-derived blood-brain-barrier shuttles. This project aims to discover new venom peptides capable of crossing the blood-brain barrier and to develop non-toxic peptide-based brain delivery systems. It addresses long-standing challenges and knowledge gaps in the delivery of macromolecules across biological barriers. Expected outcomes include an improved understanding of the strategies nature exploits to reach targets in the brain, mechanistic pathways to cross biological membranes, and innovative discovery and chemistry strategies to advance fundamental research across the chemical and biological sciences. Anticipated benefits include technological innovations relevant to Australia’s biotechnology sector and enhanced capacity for cross-disciplinary collaboration.Read moreRead less
Greening the production of peptides and proteins . This project aims to develop a green and sustainable synthetic platform for the production of peptide and protein molecules. The synthetic methodology that will be developed has the potential to solve a major technological gap in the field by providing an efficient and cost-effective method for manufacturing peptides and proteins with a substantial reduction in reagent and solvent waste over currently employed methods. Expected outcomes include ....Greening the production of peptides and proteins . This project aims to develop a green and sustainable synthetic platform for the production of peptide and protein molecules. The synthetic methodology that will be developed has the potential to solve a major technological gap in the field by providing an efficient and cost-effective method for manufacturing peptides and proteins with a substantial reduction in reagent and solvent waste over currently employed methods. Expected outcomes include the delivery of a breakthrough green technology for accessing high value peptide and protein targets in academia and industry, and the training of industry-ready early career researchers, both of which will benefit Australia’s growing biotechnology and pharmaceutical manufacturing sectors.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100134
Funder
Australian Research Council
Funding Amount
$796,206.00
Summary
Super-resolution platform to accelerate biological and molecular research. This application aims to establish a new molecular analysis platform integrating a microfluid capillary electrophoresis interface directly to a mass spectrometer with advanced data scanning technology. This enables label-free detection, quantitation and characterisation of intact proteins, lipids and metabolites with unprecedented sensitivity, resolution and throughput. It will enhance ARC projects spanning natural produc ....Super-resolution platform to accelerate biological and molecular research. This application aims to establish a new molecular analysis platform integrating a microfluid capillary electrophoresis interface directly to a mass spectrometer with advanced data scanning technology. This enables label-free detection, quantitation and characterisation of intact proteins, lipids and metabolites with unprecedented sensitivity, resolution and throughput. It will enhance ARC projects spanning natural product discovery, biotechnology, agriculture, and animal, plant and marine biology, as well as single-cell proteomics, lipidomics and metabolomics. It will ensure Australia remains at the forefront of molecular and biological research and create new training and collaborative opportunities both nationally and internationally.Read moreRead less
Peptides and Proteins for Fighting Pests and Protecting the Environment. This project aims to use peptides and proteins to fight pests and protect the environment, which is significant because current practices have unintended harmful effects and are unsustainable. Achieving these aims must first involve scientific development of ecofriendly lead molecules. This project will develop platform technologies for the design of bioactive peptides or proteins based on molecules used naturally for highl ....Peptides and Proteins for Fighting Pests and Protecting the Environment. This project aims to use peptides and proteins to fight pests and protect the environment, which is significant because current practices have unintended harmful effects and are unsustainable. Achieving these aims must first involve scientific development of ecofriendly lead molecules. This project will develop platform technologies for the design of bioactive peptides or proteins based on molecules used naturally for highly selective functions in communication and defence. Expected outcomes include novel peptide and protein leads and improved strategies for developing them, which will lead to new and safer ways of protecting biodiversity and food security that are expected to reduce our environmental footprint and bring economic benefits.Read moreRead less
Site-specific protein functionalisation at diselenides via photocatalysis . This project aims to develop a new photocatalytic reaction for the on demand functionalisation of proteins. The synthetic methodology will solve a major technological gap in the field by enabling efficient access to proteins with defined modifications at specific locations. Functionalised proteins generated in the project will underpin a detailed understanding of how specific modifications influence the structure and fun ....Site-specific protein functionalisation at diselenides via photocatalysis . This project aims to develop a new photocatalytic reaction for the on demand functionalisation of proteins. The synthetic methodology will solve a major technological gap in the field by enabling efficient access to proteins with defined modifications at specific locations. Functionalised proteins generated in the project will underpin a detailed understanding of how specific modifications influence the structure and function of several important proteins. The project will generate significant new knowledge in the fields of chemistry and biology and will foster interdisciplinary collaboration, nationally and internationally. The breakthrough technology also has the potential to benefit Australia’s biotechnology sector.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101236
Funder
Australian Research Council
Funding Amount
$444,154.00
Summary
Chimeric molecules for precision protein modification. This project aims to address fundamental questions on how natural modifications of proteins cause functional changes inside cells. The project expects to generate new knowledge in the areas of organic chemistry and chemical biology through the development of a synthetic platform for the discovery of a novel class of chimeric molecules that can trigger precise modifications of proteins. Expected outcomes include a detailed understanding of ho ....Chimeric molecules for precision protein modification. This project aims to address fundamental questions on how natural modifications of proteins cause functional changes inside cells. The project expects to generate new knowledge in the areas of organic chemistry and chemical biology through the development of a synthetic platform for the discovery of a novel class of chimeric molecules that can trigger precise modifications of proteins. Expected outcomes include a detailed understanding of how specific modifications modulate protein and cellular function. Significant benefits of this interdisciplinary project include access to a new class of molecules for basic research that may also find use for cell engineering applications within the growing biotechnology sector in Australia.Read moreRead less
Advances in Peptide Synthesis: Exploiting Underutilised Functional Groups. The translation of therapeutically-relevant classes of peptides to the clinic is often limited by chemists' ability to synthesise these complex biomolecules efficiently and sustainably. This project aims to develop new tools for the preparation of designer peptides that are broadly inspired by an underutilised reactive group found in naturally-occurring peptide sequences. Expected outcomes encompass health and economic be ....Advances in Peptide Synthesis: Exploiting Underutilised Functional Groups. The translation of therapeutically-relevant classes of peptides to the clinic is often limited by chemists' ability to synthesise these complex biomolecules efficiently and sustainably. This project aims to develop new tools for the preparation of designer peptides that are broadly inspired by an underutilised reactive group found in naturally-occurring peptide sequences. Expected outcomes encompass health and economic benefits for the Australian community, including: the first approach to a class of promising antibiotic peptide natural product analogues, the development of a mild electrochemical approach to peptide modification, and the production of a library of novel amino acids for incorporation into potential antibiotic leads.Read moreRead less
Defining a new family of sodium channel accessory proteins. Voltage-gated sodium channels are key proteins that function as multi-subunit complexes to regulate neuronal excitability. The project aims to investigate the structure and function of a novel family of accessory subunits by utilizing a class of toxins, derived from the giant Australian stinging tree, that directly binds to these proteins to modulate sodium channel function. The project aims to generate significant new knowledge on the ....Defining a new family of sodium channel accessory proteins. Voltage-gated sodium channels are key proteins that function as multi-subunit complexes to regulate neuronal excitability. The project aims to investigate the structure and function of a novel family of accessory subunits by utilizing a class of toxins, derived from the giant Australian stinging tree, that directly binds to these proteins to modulate sodium channel function. The project aims to generate significant new knowledge on the function of sodium channels as multi-protein complexes. Expected outcomes of this project include development of novel channel-modulating molecules that may have applications as neuroscience tools to address fundamental questions about ion channel function and biology.Read moreRead less
A peptide platform to fight pests threatening global food security. This project aims to develop a platform technology for the efficient design of new crop protection agents based on peptides to protect Australia’s food security. It will be first applied against the highly destructive fall armyworm, currently spreading alarmingly in Australia. The project is significant because insect pests cause huge economic and environmental impacts. Peptides are a new generation of crop protection agents tha ....A peptide platform to fight pests threatening global food security. This project aims to develop a platform technology for the efficient design of new crop protection agents based on peptides to protect Australia’s food security. It will be first applied against the highly destructive fall armyworm, currently spreading alarmingly in Australia. The project is significant because insect pests cause huge economic and environmental impacts. Peptides are a new generation of crop protection agents that are potentially more effective and sustainable than chemical pesticides. Expected outcomes are a new rapid response technology and associated lead molecules to protect against current and emerging pests. Major benefits are increased food security, improved crop yields and a more sustainable agriculture industry. Read moreRead less
Time to shine for constrained peptides as next-generation pharmaceuticals. Current methods for the screening and generation of peptide and protein drugs are laborious, expensive and often incompatible with the biological systems used in pharmaceutical industries. Leveraging recent advancements in chemistry and molecular biology, this project aims to improve the design, synthesis and screening of peptide-based pharmaceuticals. Key research outcomes are innovative biocompatible chemical transforma ....Time to shine for constrained peptides as next-generation pharmaceuticals. Current methods for the screening and generation of peptide and protein drugs are laborious, expensive and often incompatible with the biological systems used in pharmaceutical industries. Leveraging recent advancements in chemistry and molecular biology, this project aims to improve the design, synthesis and screening of peptide-based pharmaceuticals. Key research outcomes are innovative biocompatible chemical transformations for the screening of large peptide libraries, to unleash the revolutionary potential of constrained peptides in drug development. Expected benefits are reliable and cost-effective technologies for the rapid production of biologically active molecules for future targeted use in human and agricultural pharmaceuticals.Read moreRead less