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Self-perceived Oral Health Needs In Small Rural Communities In New South Wales
Funder
National Health and Medical Research Council
Funding Amount
$40,000.00
Summary
Residents of rural and remote NSW have more extractions, less focus on preventive oral heath care and lower dental satisfaction scores than metropolitan residents. There are fewer dentists in rural areas and waiting lists are lengthy. The profession must optimise the use of its limited resources in such areas to maximise the oral health care of residents. The opinions of rural and remote residents have not been considered previously. This project will determine individual and community perceptio ....Residents of rural and remote NSW have more extractions, less focus on preventive oral heath care and lower dental satisfaction scores than metropolitan residents. There are fewer dentists in rural areas and waiting lists are lengthy. The profession must optimise the use of its limited resources in such areas to maximise the oral health care of residents. The opinions of rural and remote residents have not been considered previously. This project will determine individual and community perceptions of oral health to inform the development of a community-centred oral health program.Read moreRead less
Identification Of Porphyromonas Gingivalis Genes Required For Iron/haem Acquisition And Biofilm Formation
Funder
National Health and Medical Research Council
Funding Amount
$476,836.00
Summary
Periodontal diseases are some of the most common bacterial diseases of humans and along with dental caries, account for approximately 90% of all tooth loss in the Australian population. A recent survey of oral health in Australia found that in the 30-34 age group over 20% of people had moderate to severe periodontal disease, indicating that periodontitis is a major public health problem. Specific bacteria, especially Porphyromonas gingivalis, that grow as bacterial biofilms (dental plaque) cause ....Periodontal diseases are some of the most common bacterial diseases of humans and along with dental caries, account for approximately 90% of all tooth loss in the Australian population. A recent survey of oral health in Australia found that in the 30-34 age group over 20% of people had moderate to severe periodontal disease, indicating that periodontitis is a major public health problem. Specific bacteria, especially Porphyromonas gingivalis, that grow as bacterial biofilms (dental plaque) cause periodontal disease. In this study we will utilise the latest technology available to determine which genes of the bacterium are important for biofilm growth, iron acquisition and virulence in an animal model. We will investigate how the bacterium acquires iron, as there is usually little available iron for bacterial growth on human tissues and the ability of the bacterium to free itself from this iron limitation is associated with pathogenicity. The determination of the role of iron availability in biofilm formation and virulence of the bacterium will help us to understand the changes that occur in the initiation of disease and may allow the development of early intervention strategies. The significance of this work is that we will gain an understanding of how this bacterium functions as an opportunistic human pathogen. We will determine which genes are essential for growth as a biofilm and to produce disease in an animal model. This will enable the development of therapeutic and prophylactic interventions targeted to specific bacterial gene products required to produce disease.Read moreRead less
Molecular Characterisation Of Human Periodontal Ligament Stem Cells And Their Role In Periodontal Regeneration.
Funder
National Health and Medical Research Council
Funding Amount
$92,006.00
Summary
Periodontitis is a prevalent dental condition that often leads to premature tooth loss. This project investigates the regenerative potential of periodontal ligament stem cells. It aims to identify novel markers to facilitate the isolation of these cells and to elucidate key factors and mechanisms for periodontal regeneration to occur. These findings will help to improve the predictability of current regenerative therapies and develop a successful treatment strategy for periodontitis.
Temporomandibular Disorders (TMD) are characterised by pain and limited jaw movement and are a significant issue. Current management is influenced by the view of a simple association between pain and limited movement. This study will test a new theory that an individual's motor response to pain is influenced by the complexity of the jaw motor system as well as the individual's pain experience. This project will point towards individualised recommendations for effective management of TMD.
Cellular Regulation Of Tooth Matrix Deposition And Remineralisation
Funder
National Health and Medical Research Council
Funding Amount
$124,530.00
Summary
Caries is one of the most prevalent of all human diseases. It has a very significant impact on the health budget of a nation apart from its effect on the individual concerned. In recent years there has been a growing recognition that healing or re-mineralisation protocols for the treatment of carious lesions in dentine are possible, rather than just relying on surgical removal of the diseased tissue and placement of restoratives. This project proposes to investigate a strategy for deliberately s ....Caries is one of the most prevalent of all human diseases. It has a very significant impact on the health budget of a nation apart from its effect on the individual concerned. In recent years there has been a growing recognition that healing or re-mineralisation protocols for the treatment of carious lesions in dentine are possible, rather than just relying on surgical removal of the diseased tissue and placement of restoratives. This project proposes to investigate a strategy for deliberately stimulating cellular reparative processes for the treatment of this disease. It is expected that the outcomes from this research will have a major influence on the techniques and materials used to treat this disease. They will potentially have a very broad application from the paediatric to the geriatric sectors of the dental profession.Read moreRead less
Associations Between Periodontal Disease And Cardiovascular Surrogate Endpoints In An Adult Indigenous Population
Funder
National Health and Medical Research Council
Funding Amount
$413,242.00
Summary
The relationship between periodontal disease and cardiovascular risk markers, both of which are high among the Indigenous Australian population, is established. This study seeks to explore the prevalence of periodontal disease and cardiovascular risk markers among this population, and to determine if implementation of a periodontal intervention leads to improved cardiovascular risk outcomes. There may be benefit in applying this model to other areas of Indigenous health promotion and research.
The Impact Of Insurance On Use Of Dental Services And Oral Health
Funder
National Health and Medical Research Council
Funding Amount
$203,616.00
Summary
Dental problems are very common in the Australian population, and health expenditure on dental services is large. This project addresses the impact of dental insurance on use of dental services and oral health outcomes to investigate the effect of insurance on dental visit patterns and mix of dental services provided, and examine how the cost of dental care is related to outcomes such as tooth loss and quality of life.