ARDC Research Link Australia

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $504,097.00
Summary: Tissue-type plasminogen activator (t-PA) is used clinically to remove blood clots. Recently, a role for t-PA in the brain was discovered where under pathological conditions it can promote ischaemic and excitotoxic brain injury. This project will examine the mechanisms by which t-PA promotes injury to brain cells. It is anticipated that results obtained could be used to devise a means to reduce t-PA toxicity in the brain that would be of therapeutic benefit for patients with ischaemic stroke.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $749,022.00
Summary: The Alzheimer's disease Amyloid Precursor Protein (APP) is central to the cause of Alzheimer's disease (AD). It's metabolised into the neurotoxic amyloid beta (Abeta) peptide that is deposited in AD brains. The sorLA protein is a neuronal protein that interacts with APP and alters its metabolism into Abeta. This grant will study the interaction between APP and sorLA and define the APP binding site for sorLA which represents a potential drug target.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $209,654.00
Summary: The presenilin proteins are key components in the development of Alzheimer's disease. Mutations in these proteins can cause early Alzheimer's disease. We will continue our study of the biochemistry and cell biology of these proteins using tools and experimental models that we have already developed. This will provide important information on the mechanism of the disease process and give new leads in the treatment of the disease. The new technologies of genetic screening for presenilin mutations ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $249,750.00
Summary: Multiple sclerosis is a disease of the central nervous system in which myelin (an insulative coating around the axons of neurons) and oligodendrocytes (the cells that produce myelin) are attacked and damaged by an unknown process. This damage is referred to as demyelination and results in a blocking or weakening of nerve signal conduction. Some of the symptoms of multiple sclerosis are weakness, tingling or numbness of limbs, and double vision or visual loss. One strategy to repair the demyelina ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $443,250.00
Summary: Muscle cells may be broadly divided into two classes, slow- or fast-twitch, with different physiological and biochemical properties. These properties are largely determined by the protein products of several multi-gene families that encode the contractile apparatus characteristic of muscle cells. The pattern of expression of these muscle-specific genes defines a muscle cell as either a slow-twitch or fast-twitch myofibre. Skeletal muscle is inherently plastic in its ability to express different ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $380,558.00
Summary: This project aims to identify the role of immune and inflammatory components in the pathology of neurodegenerative disease. Additionally, this research will determine whether a new class of novel anti-inflammatory drugs can alter the neurodegenerative process. This will allow for an increased understanding of the biology of neurodegenerative disease, and also may lead to the development of new treatments for conditions such as Parkinson’s disease, Huntington’s disease and motor neuron disease.

Funded Activity

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $340,350.00
Summary: Vestibular Activation in Benign Paroxysmal Positional Vertigo and Superior Semicircular Canal Dehiscence The aim of this project is to study the pathological activation of the vestibular system in benign paroxysmal positional vertigo and superior canal dehiscence in order to achieve an improved diagnosis in both conditions and a more effective treatment for benign paroxysmal positional vertigo. These diseases provide unique opportunities to study unilateral activation of an otherwise normal huma ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $241,018.00
Summary: The inability to form new memories is a major and increasingly prevalent health problem for an aging population. In addition to aging, the inability to form new memories is associated with serious medical conditions including Alzheimer's Disease and diabetes. Common to these conditions is the inability to consolidate memories. Memories are intact for a short while (30 minutes) after the event to be remembered, but memory does not pass on into permanent storage. We have been able to achieve memor ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $577,556.00
Summary: It is increasingly recognised that Alzheimer’s disease can emerge slowly over years and persons presenting with memory impairment, or mild cognitive impairment (MCI), are at increased risk of developing Alzheimer’s disease. Following diagnosis of MCI, active management through symptomatic drug treatment remains equivocal, therefore, memory impairment continues to be troublesome and patients and families are seeking interventions that offer improvement in quality of life. Cognitive interventions ....
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