Transition From Hospital To Home: Effectiveness Of An Occupational Therapy Home Visit Discharge Planning Program For At-risk Older Adults
Funder
National Health and Medical Research Council
Funding Amount
$1,020,026.00
Summary
Occupational therapy discharge planning with at-risk older people aims to enable safe and independent transition from hospital to home. Previous research shows how potentially serious problems identified on home visits with the client were not identified in hospital consultations. This randomised trial will evaluate the efficacy of the HOME discharge planning intervention in enhancing outcomes for older people and its cost effectiveness.
Physiological Mechanisms Of Experimental Preeclampsia.
Funder
National Health and Medical Research Council
Funding Amount
$471,862.00
Summary
Defining the sequence of abnormalities of immune system regulation and vascular reactivity would greatly enhance our understanding of the underlying mechanisms of preeclampsia (hypertension in pregnancy) and lead to opportunities for definitive treatment for the mother and baby other than by urgent delivery of the pregnancy. Results from this study may lead to tests in early pregnancy of the hypoxic environment such as cytokine imbalance.
Ryanodine Receptor Inhibitors As Therapy For Ca2+ Store Overload Induced Arrhythmias
Funder
National Health and Medical Research Council
Funding Amount
$555,892.00
Summary
This study investigates a new therapeutic action recently discovered for flecainide, an antiarrhythmic agent that we find to completely prevent and inherited form of stress-induced arrhythmias called CPVT. The findings will provide the first detailed mechanistic understanding of an antiarrhythmic drug, findings that will also give a new direction for drug design to control common arrhythmias such as occur in diseases such as coronary artery disease.
Antiphospholipid Syndrome Related Thrombosis: Understanding The Disease Pathogenic Mechanisms Is The Key To Better Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$607,497.00
Summary
Patients with the Antiphospholipid Syndrome develop thrombosis at a young age. It requires long-term treatment with blood thinning medications, which have risks of severe bleeding. Methods are needed to decide which patients require long term treatment, avoiding unnecessary treatment in low risk patients. Such methods do not currently exist. In this study we explore how useful two novel assays developed by us are in identifying which of these patients are at high risk of thrombosis.
Angiotensin II AT2 Receptor In Diabetic Atherosclerosis
Funder
National Health and Medical Research Council
Funding Amount
$477,472.00
Summary
Activation of the angiotensin 2 receptor may have effects leading to large artery disease in diabetes. We will investigate the role of the AT2 receptor in diabetes using knockout animals, novel blockers and activators and most importantly the role of the AT2 receptor in macrophages in diabetes.