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Roles Of Vitamin D In Skeletal Muscle And Satellite Cells
Funder
National Health and Medical Research Council
Funding Amount
$380,891.00
Summary
Vitamin D deficiency leads to muscle pain and weakness that are reversible with vitamin D supplementation. However, precise biological effects of vitamin D in skeletal muscle are unclear. In this fellowship, novel mouse models and innovative techniques will be used to examine vitamin D signalling pathways in whole muscle and muscle stem cells. Ultimately, the therapeutic potential of the vitamin D pathway in treatment of muscle disorders and age-related muscle wasting will be explored.
Improving road safety: advanced hybrid vehicle-based technology for monitoring driver drowsiness. Innovative technology geared towards reducing road accidents and fatalities (for improving public health) will constitute major socio-economic benefit to Australia. The Australian Transport Safety Bureau notes fatigue as a major cause of road accidents (2006). The World Health Organisation dedicated World Health Day 2004 to road safety and emphasized the importance of combating fatigue ('Road Safety ....Improving road safety: advanced hybrid vehicle-based technology for monitoring driver drowsiness. Innovative technology geared towards reducing road accidents and fatalities (for improving public health) will constitute major socio-economic benefit to Australia. The Australian Transport Safety Bureau notes fatigue as a major cause of road accidents (2006). The World Health Organisation dedicated World Health Day 2004 to road safety and emphasized the importance of combating fatigue ('Road Safety is no Accident'). This research will develop an innovative driver drowsiness detecting technology. With drowsiness attributable to substantial road fatalities, this technology aims to reduce this emotional and socio-economic burden on the community, contributing to national and community benefit by providing a safer road environment.Read moreRead less
Establishing STARS As A Therapeutic Target To Reduce Muscle Wasting And Improve Muscle Function
Funder
National Health and Medical Research Council
Funding Amount
$446,189.00
Summary
Muscle wasting occurs rapidly with disuse after injuries occurring at work, during sport, with chronic disease and in road accidents. It is also a consequence of ageing. Muscle wasting and reduced muscle function places considerable financial strain on our health care system. We aim to use gene therapy and pharmacological interventions to increase the levels of a protein called STARS. We hypothesize that STARS will reduce disuse-induced muscle wasting, increase recovery and improve function.
Mechanisms Underlying The Efficacy Of Bariatric Surgery – Insights From Rat Models Of Sleeve Gastrectomy And The Adjustable Gastric Band
Funder
National Health and Medical Research Council
Funding Amount
$868,472.00
Summary
Bariatric surgery is the only effective treatment for morbid obesity. In order to better understand the mechanistic bases of two such procedures, the adjustable gastric band and sleeve gastrectomy, we have developed rodent models. Here we use these models to better understand the physiology and pathophysiology of these surgeries and extend these findings to inform part of a RCT aimed at identifying the basis for effective joint surgical and medicinal treatments of obesity.
This research proposal will identify changes in liver-secreted proteins during the development of fatty liver, and in the transition from fatty liver to the more advanced form of liver disease, non-alcoholic steatohepatitis (NASH). Understanding the differences in protein secretion between NASH patients and patients with normal/fatty liver will provide the opportunity to identify disease biomarkers that could be determined from a blood sample. This will provide a major shift in clinical care.
Altered Protein Secretion Links The Fatty Liver To Metabolic Disease
Funder
National Health and Medical Research Council
Funding Amount
$415,797.00
Summary
The liver secretes proteins to alter metabolism in other tissues of the body. Fatty liver is a major feature of obesity and type 2 diabetes. This project aims to understand how fatty liver changes protein secretion and how this impacts on metabolic processes. The outcomes of this project will be the identification of protein biomarkers of fatty liver and the prediction of insulin resistance development in other tissues of the body.
The intestinal lining is continuously renewed by specialised cells called intestinal stem cells. Stem cells throughout the body are regulated by nearby connective tissues. But, the identity of these supportive cells in the gut are unknown. We test whether a discrete population of connective tissue cells in the gut support intestinal stem cells. This project will identify new cellular therapies and targets to promote intestinal repair and manage intestinal cancer.
The Role Of Vitamin D In Beta-cell Function And Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$554,248.00
Summary
Vitamin D deficiency is common in Australia, with the success of the 'slip, slop, slap' campaigns. Low levels of Vitamin D have been associated with diabetes. This grant aims to determine how vitamin D affects insulin release and blood glucose levels.
Determining The Mechanism Of Obesity Induced Elevated Blood Pressure And Glucose Dysregulation.
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
My research focuses on determine the link and mechanisms behind the development of metabolic diseases in obesity and specifically determining the reason for the development of diabetes and cardiovascular diseases. In this area I have been able to generate strong physiological techniques which have enabled answering these questions possible, and I endeavor to continue to create and establish new techniques to continue to answer physiological questions.
Mechanisms Of DNA Damage-induced Oocyte Apoptosis And Infertility: Examination Of The Role Of BH3-only Proteins.
Funder
National Health and Medical Research Council
Funding Amount
$495,755.00
Summary
Our ability to prevent or postpone menopause following cancer treatment, is of great importance for female fertility, health and quality of life. We will demonstrate that the death gene of the Bcl-2 family of life and death genes, Puma, is responsible for killing female germ cells after damaging treatment. When Puma is absent, sufficient high quality germ cells are able to survive damaging treatment, allowing normal fertility in mice. The quality of these rescued germ cells will be analysed in d ....Our ability to prevent or postpone menopause following cancer treatment, is of great importance for female fertility, health and quality of life. We will demonstrate that the death gene of the Bcl-2 family of life and death genes, Puma, is responsible for killing female germ cells after damaging treatment. When Puma is absent, sufficient high quality germ cells are able to survive damaging treatment, allowing normal fertility in mice. The quality of these rescued germ cells will be analysed in detail.Read moreRead less