A novel magnetic resonance imaging (MRI) technique to characterise white matter microstructure in the brain. Integrity of the cellular architecture of brain white matter (WM) is vital to normal signal conduction and is disrupted in diseases such as multiple sclerosis. Due to their characteristic molecular arrangements, WM microstructures have distinct magnetic susceptibility characteristics that can be detected with high-field and ultra high-field magnetic resonance imaging (MRI). The objective ....A novel magnetic resonance imaging (MRI) technique to characterise white matter microstructure in the brain. Integrity of the cellular architecture of brain white matter (WM) is vital to normal signal conduction and is disrupted in diseases such as multiple sclerosis. Due to their characteristic molecular arrangements, WM microstructures have distinct magnetic susceptibility characteristics that can be detected with high-field and ultra high-field magnetic resonance imaging (MRI). The objective of this project is to develop and validate a novel method of mapping susceptibility effects at high (sub-voxel) resolution with MRI. The outcomes will be a more comprehensive understanding of the relationship between changes in MRI signal and WM microarchitecture and improved susceptibility mapping that may lead to earlier diagnosis and more effective therapeutic monitoring.Read moreRead less
Novel technologies for motion-compensated simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) imaging. The aim of this work is to develop motion tracking and motion correction techniques for an emerging hybrid imaging technology, MR-PET. The MR-PET scanner simultaneously acquires structural MR images and functional PET images. The work will provide clearer images without the effects of motion blur for both research and clinical applications.
Spatiotemporal dynamics and analysis of functional magnetic resonance imaging. Functional magnetic resonance imaging (fMRI) produces signals generated by brain activity in fine detail, but links between activity and images are poorly understood, posing a barrier to full use of the technology. Predictions from our new theory of such links will be made, tested experimentally and used to improve fMRI and discover new phenomena.
A new technique for the assessment of burns. This international, interdisciplinary collaborative project should change the way skin burns are assessed with a broad impact on biotechnology, healthcare and non destructive testing. This project will build on Australia's position as a leader in terahertz technology with significant potential for commercialisation.
A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired d ....A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired digital image can thus be used to simultaneously verify geometric accuracy (correct patient positioning) and dosimetric accuracy (correct dose distribution). This is not currently possible with existing X-ray detector technology and offers an improvement in treatment accuracy.Read moreRead less