Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Evolution of immunoregulatory networks: preventing autoimmunity at the expense of perpetuating chronicity in persistent infections. Chronic pathogens like HIV take advantage of human genes that regulate immune responses, which evolved to prevent autoimmunity, enabling them to evade eradication. This project defines the nature and interplays between these genes and will provide valuable clues as to how immunity can be manipulated to promote clearance of persistent infections.
Discovery Early Career Researcher Award - Grant ID: DE120101340
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Subversion of innate immune responses by pathogenic Escherichia coli. This project will determine how bacteria that cause diarrhoeal diseases prevent the immune system from signalling efficiently. It will provide important information not only about how the bacteria establish disease, but also provide insight into the host response in the early stages of infection.