Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100043
Funder
Australian Research Council
Funding Amount
$435,279.00
Summary
High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super ....High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super-solution imaging of single molecules in live cells. This facility will provide capability for researchers pursuing industry transformation and other initiatives in the development of advanced materials, biomolecular sciences, nanotechnology, photonics and device engineering.Read moreRead less
Developing the basis for an quality control platform for human pluripotent stem cells and their differentiated derivatives. Biophotonic techniques based on spectroscopy have the potential to provide low-cost, automatable measurements for the quality control of stem and differentiated cells produced for use in industry and regenerative medicine. This project is aimed at acquiring the fundamental scientific knowledge base required to bring this about.
Defining targets and generating tools/therapeutic agents for prevention, diagnosis and therapy of atherothrombosis. Atherosclerosis and its complications such as myocardial infarction and stroke are a major cause of death and disability in Australia and worldwide. The proposed research program investigates new therapeutic targets and concepts (e.g. targeting of stem cells) to treat atherosclerosis and aims to develop new therapeutic agents using modern biotechnological methods. The project furth ....Defining targets and generating tools/therapeutic agents for prevention, diagnosis and therapy of atherothrombosis. Atherosclerosis and its complications such as myocardial infarction and stroke are a major cause of death and disability in Australia and worldwide. The proposed research program investigates new therapeutic targets and concepts (e.g. targeting of stem cells) to treat atherosclerosis and aims to develop new therapeutic agents using modern biotechnological methods. The project further aims to develop nanoparticle-based diagnostic tools to identify and preventatively treat atherosclerotic plaques that are prone to cause myocardial infarction. The expected outcome will provide direct benefit to patients and create new economic opportunities in Australian bio-/nanotechnology.Read moreRead less
Development of new systems for the commercial collection, processing and storage of adipose stem cells. This project is aimed at developing a standardised method to commercially extract and expand stem cells from adipose tissue. This product will then be available commercially as a therapeutic treatment.
Discovery Early Career Researcher Award - Grant ID: DE190100174
Funder
Australian Research Council
Funding Amount
$400,747.00
Summary
Calcium-mediated regulation of stem cell development. This project aims to clarify the role of syndecan-mediated calcium in stem cell development using Caenorhabditis elegans. Stem cells have great potential for regenerative studies. While stem cells cultures are widely used, we do not fully understand how stem cells develop within an organism. This project expects to uncover the mechanisms underpinning calcium regulation by syndecan in stem cells. The expected outcomes include the optimisation ....Calcium-mediated regulation of stem cell development. This project aims to clarify the role of syndecan-mediated calcium in stem cell development using Caenorhabditis elegans. Stem cells have great potential for regenerative studies. While stem cells cultures are widely used, we do not fully understand how stem cells develop within an organism. This project expects to uncover the mechanisms underpinning calcium regulation by syndecan in stem cells. The expected outcomes include the optimisation of C. elegans stem cell methods to screen calcium regulating compounds and the creation of an in vivo calcium sensor. The project should advance knowledge of the role of syndecans in stem cells and provide the first analysis of in vivo calcium kinetics in stem cells.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC140100023
Funder
Australian Research Council
Funding Amount
$1,800,000.00
Summary
ARC Training Centre in Biodevices. ARC Training Centre in Biodevices. The Training Centre aims to assist Australian biodevice and diagnostics companies to develop the next generation of innovative and profitable products that address important healthcare needs in our communities. This will be achieved by addressing industry-specific challenges relating to the multidisciplinary nature of design and development in the biodevices and diagnostics sector; technology uptake and transfer to manufacturi ....ARC Training Centre in Biodevices. ARC Training Centre in Biodevices. The Training Centre aims to assist Australian biodevice and diagnostics companies to develop the next generation of innovative and profitable products that address important healthcare needs in our communities. This will be achieved by addressing industry-specific challenges relating to the multidisciplinary nature of design and development in the biodevices and diagnostics sector; technology uptake and transfer to manufacturing; the composition, maturity and size of local firms in the sector; and the development of high-level entrepreneurial skills for innovative industry researchers. The Training Centre will remove barriers to collaboration between universities and industry by delivering exceptional return on research investment.Read moreRead less
Environmental impact on neuroendocrine and neurobiological mechanisms: treatment strategies and mimetics for maintaining good health. The current societal climate of industrialized countries such as Australia has shifted considerable over recent decades and is now one which is highly conducive to overfeeding and reduced physical activity. As a result, the incidence of obesity has risen markedly along with an associated increase in obesity-related chronic diseases such as cardiovascular disease, ....Environmental impact on neuroendocrine and neurobiological mechanisms: treatment strategies and mimetics for maintaining good health. The current societal climate of industrialized countries such as Australia has shifted considerable over recent decades and is now one which is highly conducive to overfeeding and reduced physical activity. As a result, the incidence of obesity has risen markedly along with an associated increase in obesity-related chronic diseases such as cardiovascular disease, stroke, obstructive pulmonary disease, type II diabetes, and many types of cancers. Less is known about the psychological and behavioural sequelae of this overfeeding. Calorie restriction mimetics may not only act as a preventative intervention to help reduce the incidence and severity of these major health problems, but also impact on social behaviour.Read moreRead less
Dissecting the physiology of multipotent mesenchymal stromal cells to develop vaccine candidates for respiratory disease. The project aims to gain an understanding of how a type of adult stem cell inhibits immune responses that cause asthma. The project will produce new stem cell products and facilitate the design of a vaccine for asthma and other respiratory diseases, which would greatly reduce the burden of such conditions.
Novel technology platform for gene delivery into intact cells. Delivery of DNA to cells is a crucial but highly inefficient process. This project will develop a way to manipulate the genetic code of cells efficiently and to easily generate stem cells from normal adult cells, thus avoiding controversial embryonic harvesting. This new technology will have potential benefits for research, agriculture and humans alike.
Molecular signals that regulate the regenerative properties of intestinal epithelial cells. Most cancer deaths are due to the cancer spreading to other organs. Cancer is much more difficult to treat once it has spread to other organs in the body where the cancer cells can exist in a dormant state. Dormant cancer cells evade conventional anticancer treatment and can remain dormant for a very long time before they change back to a 'tumour-growing' state. An understanding of how the cancer initiati ....Molecular signals that regulate the regenerative properties of intestinal epithelial cells. Most cancer deaths are due to the cancer spreading to other organs. Cancer is much more difficult to treat once it has spread to other organs in the body where the cancer cells can exist in a dormant state. Dormant cancer cells evade conventional anticancer treatment and can remain dormant for a very long time before they change back to a 'tumour-growing' state. An understanding of how the cancer initiating (stem cell) property of tumour cells is maintained offers potential novel avenues to eliminate persistent cancer cells. This knowledge will ultimately lead to better management and treatment of cancer, and increase survival. An understanding of stem cell behaviour is also central to the control of degenerative conditions.Read moreRead less