Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100021
Funder
Australian Research Council
Funding Amount
$2,168,000.00
Summary
Australian Metabolic Phenotyping Centre (AMPC). This project aims to establish a centre for targeted and exploratory metabolic phenotyping. Metabolic phenotyping quantitatively measures the precursors, intermediates and products of metabolism interacting within a biological system. This project will use high-resolution spectrometry and spectroscopy to generate comprehensive, multi-parameter metabolite data sets for biological samples at the population level, at unprecedented throughput and low c ....Australian Metabolic Phenotyping Centre (AMPC). This project aims to establish a centre for targeted and exploratory metabolic phenotyping. Metabolic phenotyping quantitatively measures the precursors, intermediates and products of metabolism interacting within a biological system. This project will use high-resolution spectrometry and spectroscopy to generate comprehensive, multi-parameter metabolite data sets for biological samples at the population level, at unprecedented throughput and low cost, to address biological and biomedical research needs. This project is expected to make Australian scientists globally competitive in the life sciences including biological, clinical and biomedical, plant and crop sciences, analytical chemistry, toxicology, agriculture, wildlife conservation and sports science, and to drive advances in the data sciences for systems biology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100239
Funder
Australian Research Council
Funding Amount
$480,000.00
Summary
Small biological molecule tissue imaging mass spectrometry facility for Western Australia for spatial metabolomics and lipidomics. This tissue imaging facility for Western Australia will provide researchers with access to much needed instrumentation. The facility will support major research efforts in key disciplines, including agriculture and animal science, fisheries and medical science.
Industrial Transformation Research Hubs - Grant ID: IH180100006
Funder
Australian Research Council
Funding Amount
$4,995,391.00
Summary
ARC Research Hub for Medicinal Agriculture . The ARC Research Hub for Medicinal Agriculture aims to transform the production of high quality plant-derived therapeutics into an integrated, national industry that spans primary producers and manufacturers. The Hub will establish a multi-disciplinary collaboration with industry. This Hub will address agronomy and cultivation, germplasm generation, novel extraction technologies and chemistries, through to the discovery and functional characterisation ....ARC Research Hub for Medicinal Agriculture . The ARC Research Hub for Medicinal Agriculture aims to transform the production of high quality plant-derived therapeutics into an integrated, national industry that spans primary producers and manufacturers. The Hub will establish a multi-disciplinary collaboration with industry. This Hub will address agronomy and cultivation, germplasm generation, novel extraction technologies and chemistries, through to the discovery and functional characterisation of novel lead compounds. This knowledge will be applicable across related industries and build the specialised workforce needed to underpin Australia’s developing medicinal agriculture industry.Read moreRead less
Control Of Bone Remodelling By Osteoclastic Metabolism Of Vitamin D
Funder
National Health and Medical Research Council
Funding Amount
$694,635.00
Summary
Vitamin D is essential for bone health. This study will build on our extensive body of preliminary data to investigate the extent to which bone-resorbing osteoclasts are controlled by circulating levels of the pro-hormone 25-hydroxyvitamin D. Our work will identify new approaches to the treatment of osteoporosis, by targetting the osteoclast as a vitamin D-responsive cell type.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100158
Funder
Australian Research Council
Funding Amount
$670,000.00
Summary
High resolution mass spectrometry for metabolomics and proteomics research. High resolution mass spectrometry for metabolomics and proteomics research: Ultra-high resolution mass spectrometry and capillary electrophoresis are expected to greatly enhance separation and mass analysis for multi-disciplinary research. Biological processes, and the metabolites and proteins that control them, will be analysed at rates, sensitivities and resolutions which are expected to significantly advance molecular ....High resolution mass spectrometry for metabolomics and proteomics research. High resolution mass spectrometry for metabolomics and proteomics research: Ultra-high resolution mass spectrometry and capillary electrophoresis are expected to greatly enhance separation and mass analysis for multi-disciplinary research. Biological processes, and the metabolites and proteins that control them, will be analysed at rates, sensitivities and resolutions which are expected to significantly advance molecular and cell biology research. Multiple levels and types of fragmentation will allow complex experiments to be conducted and provide new mechanisms to aid plant and crop science, sports science, energy and resource science, and chemical toxicology. Comparative and systems biology, where analysis of rare or complex samples is a key requirement, will be strongly supported by these new facilities.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100018
Funder
Australian Research Council
Funding Amount
$630,000.00
Summary
Purchase of a high resolution Nuclear Magnetic Resonance spectrometer with liquid chromatography module. A high resolution Nuclear Magnetic Resonance spectrometer and liquids separation module will support Tasmanian research of international significance across the biological and medical sciences, chemistry and Tasmanian industries including profiling studies in human health, plant biology, molecular basis of disease and complex mixture analysis.
Improving plant productivity and human health using next generation biotechnology approaches. Both medical and plant sciences face similar technological problems in harnessing the power of modern DNA sequencing for accelerating the pace of beneficial gene function discovery. Plant and animal researchers will collaborate in this program to meet this common challenge. The research outcomes envisaged in this proposal will benefit human health by enabling more rapid discovery of genes related to obe ....Improving plant productivity and human health using next generation biotechnology approaches. Both medical and plant sciences face similar technological problems in harnessing the power of modern DNA sequencing for accelerating the pace of beneficial gene function discovery. Plant and animal researchers will collaborate in this program to meet this common challenge. The research outcomes envisaged in this proposal will benefit human health by enabling more rapid discovery of genes related to obesity, immunity, fertility, neurological function and cancer. In the plant sphere, the outcomes will shed new light on plant functions related to plant energy metabolism, vitamin biosynthesis drought tolerance and water use by crops. The research will benefit both human health and agricultural food production and quality.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100036
Funder
Australian Research Council
Funding Amount
$771,000.00
Summary
Nuclear magnetic resonance spectroscopy facilities - Advancing cutting-edge chemical, biological, energy and materials research in Western Australia. Nuclear magnetic resonance spectroscopy facilities: advancing cutting-edge chemical, biological, energy and materials research: This project will establish new nuclear magnetic resonance spectroscopy facilities supporting high-throughput metabolite detection, diffusion measurement, and small-volume sample identification. The project will support re ....Nuclear magnetic resonance spectroscopy facilities - Advancing cutting-edge chemical, biological, energy and materials research in Western Australia. Nuclear magnetic resonance spectroscopy facilities: advancing cutting-edge chemical, biological, energy and materials research: This project will establish new nuclear magnetic resonance spectroscopy facilities supporting high-throughput metabolite detection, diffusion measurement, and small-volume sample identification. The project will support research across diverse priorities including: energy and minerals; ecology, evolution and the environment; and medicine and health. The project will open new opportunities for areas such as metabolomics and oil and gas processing, and greatly expand capacity to meet strongly increasing demand.Read moreRead less
Identifying Drug Targets In Microbial Pathogens Using Metabolomics
Funder
National Health and Medical Research Council
Funding Amount
$763,409.00
Summary
Infectious diseases such as malaria, leishmaniasis and tuberculosis cause enormous morbidity and mortality worldwide. This proposal will utilize advanced analytical and genetic approaches to study the metabolism of the respective protozoan and bacteria agents as well as the associated host responses. These approaches will be used to develop novel therapeutic approaches and new analytical tools that can be applied to other infectious diseases