Fluid Dynamics of Circulation: Focus on the Kidney. In Australia, about 30% of adults have hypertension, a major risk factor for heart disease, accounting for about 40% of all deaths. Problems in renal circulation are likely factors leading to hypertension. A detailed understanding of the renal circulation, of whose hydraulic characteristics we have limited knowledge, is required before we can cure or prevent hypertension. We will determine how the size, structure and geometry of the blood vesse ....Fluid Dynamics of Circulation: Focus on the Kidney. In Australia, about 30% of adults have hypertension, a major risk factor for heart disease, accounting for about 40% of all deaths. Problems in renal circulation are likely factors leading to hypertension. A detailed understanding of the renal circulation, of whose hydraulic characteristics we have limited knowledge, is required before we can cure or prevent hypertension. We will determine how the size, structure and geometry of the blood vessels influence the function of the kidney. This will lead to predictive models to aid the design and interpretation of physiological studies and the combat of hypertension. It will also help in the ongoing development of bioartificial kidneys to replace present dialysis systems. Read moreRead less
FLOW STUDIES OF CELL CULTURE BIOREACTORS. The proposed research program consists of a number of stages, amongst which is the study of flows within mixed flasks, the study of a small-scale Taylor-Couette vessel, and the development of a three-dimensional Holographic Particle Image Velocimetry flow measurement system. A successful project will be a valuable contribution to the development of cell and tissue scale up systems. In the long term, such systems will potentially provide the means of grow ....FLOW STUDIES OF CELL CULTURE BIOREACTORS. The proposed research program consists of a number of stages, amongst which is the study of flows within mixed flasks, the study of a small-scale Taylor-Couette vessel, and the development of a three-dimensional Holographic Particle Image Velocimetry flow measurement system. A successful project will be a valuable contribution to the development of cell and tissue scale up systems. In the long term, such systems will potentially provide the means of growing cell and tissue in quantities suitable for implantation or use in other therapeutic applications that are currently deemed impossible.Read moreRead less
Crack Propagation within Graded Interfaces. Functionally graded interfaces are a technologically new way of joining materials in a wide range of biomedical and industrial applications. The reduction in the interfacial stresses resulting from the graded interface increases the structural integrity of the component, however, existing models do not fully address issues of plasticity and cyclic fatigue to their fracture. The intention of this study is to investigate how modifications to the ductil ....Crack Propagation within Graded Interfaces. Functionally graded interfaces are a technologically new way of joining materials in a wide range of biomedical and industrial applications. The reduction in the interfacial stresses resulting from the graded interface increases the structural integrity of the component, however, existing models do not fully address issues of plasticity and cyclic fatigue to their fracture. The intention of this study is to investigate how modifications to the ductile reinforcement phase and how the cyclic loading influence crack extension within a graded interface. These results will assist in future design and prediction of the in-service lifetime of components containing gradient interfaces.Read moreRead less
Understanding multi-scale reinforcement of carbon fibre composites. Addition of nano scale entities, such as nanotubes, on the surface of a carbon fibre forms a bottle-brush like architecture and strengthens fibre-matrix interface. This project will pioneer development of a systematic approach for analysis and design of such multi-scale reinforced composite materials for use in aerospace and civil industries.
A novel multiscale model to investigate mechanical properties of cartilage. This project aims to develop a new multiscale model to investigate anisotropic and inhomogeneous mechanical properties of cartilage. It has been found that the mechanical properties of cartilage highly depend on its microstructures and components. The new model is proposed based on a new constitutive relation in the macroscale and a novel algorithm to obtain local stress distributions in the microscale as well as through ....A novel multiscale model to investigate mechanical properties of cartilage. This project aims to develop a new multiscale model to investigate anisotropic and inhomogeneous mechanical properties of cartilage. It has been found that the mechanical properties of cartilage highly depend on its microstructures and components. The new model is proposed based on a new constitutive relation in the macroscale and a novel algorithm to obtain local stress distributions in the microscale as well as through rigorous experimental validations. This model will be a powerful tool to understand cartilage mechanical properties. It will accelerate the design of mechanically viable artificial cartilage biomaterial, which will provide significant economic benefits and place Australia in the forefront of modelling and biomaterials.Read moreRead less
A novel multiscale modelling technique to explore mechanical deformation of nanowires in high-performance devices. A novel multiscale modelling technique with a number of key innovations will be developed. This new model is capable of taking account of the surface effects which are important for nanowires and will enhance prediction accuracy and provide knowledge beyond current experimental measurements to underpin performance of new devices.
Dislocation motion and anelastic recovery in layered ceramic titanate. This project aims to research deformation and facture in brittle ceramic nanowire materials and anelastic behaviour in tensile deformation. Layered sodium titanate is used in energy storage and water treatment, but in-situ tensile tests have observed unconventional deformation behaviour, with significant dislocation motion and anelastic recovery. This project will study the deformation mechanism in layered sodium titanate nan ....Dislocation motion and anelastic recovery in layered ceramic titanate. This project aims to research deformation and facture in brittle ceramic nanowire materials and anelastic behaviour in tensile deformation. Layered sodium titanate is used in energy storage and water treatment, but in-situ tensile tests have observed unconventional deformation behaviour, with significant dislocation motion and anelastic recovery. This project will study the deformation mechanism in layered sodium titanate nanowires through molecular dynamics simulations, empirical interatomic potential, and in situ TEM experiments. Expected outcomes include knowledge of the deformation mechanism of this layered titanate which can be broadened to technologically important layered ceramic materials.Read moreRead less
Improved design and operational efficiency of small wind turbines in unsteady flows. The purpose of this research is to improve the design and performance of small wind turbines for energy generation. The expected outcomes are novel control strategies and mechanical designs that account for unsteady aerodynamics and its effects on structural loads and power quality. Recommendations to improve current design standards will be made.
Design of nastic cellular structures with osmotic actuation. Shape changing structures play an imperative role in aerospace, automobile, energy and other industries. This project aims to develop novel concepts extracted from nastic motion in plants and relevant computational algorithms for the design of nastic cellular structures with osmotic actuation. The project is of significance as it offers a potential solution to the shape morphing challenge in aircraft and automobile from biomimetics vie ....Design of nastic cellular structures with osmotic actuation. Shape changing structures play an imperative role in aerospace, automobile, energy and other industries. This project aims to develop novel concepts extracted from nastic motion in plants and relevant computational algorithms for the design of nastic cellular structures with osmotic actuation. The project is of significance as it offers a potential solution to the shape morphing challenge in aircraft and automobile from biomimetics viewpoint - nastic actuation. The expected outcomes will be: a new numerical method for designing nastic cellular structures; and, validated algorithms with a novel topological geometry representation and multi objectives and constraints for applications in morphing structures with multiple target shapes.Read moreRead less
Topology optimisation? An engineering approach to design of metamaterials. Metamaterials offer unusual physical properties and have significant potential to many technological innovations in precision instrument, medical, telecommunication, space and defence industries in the future. This project aims to develop a computational method for metamaterials so that they can be designed in an effective way.