New mathematics of fractional diffusion for understanding cognitive impairment at the neuronal level. As Australia's population ages, cognitive impairment due to cortical ageing and neurodegeneration is looming as the nation's greatest health problem. The project will deliver new, more realistic, mathematical models for a mechanistic understanding of cognitive impairment at the neuronal level. This understanding is a vital first step in targeting drugs, e.g., to influence neuronal spine proper ....New mathematics of fractional diffusion for understanding cognitive impairment at the neuronal level. As Australia's population ages, cognitive impairment due to cortical ageing and neurodegeneration is looming as the nation's greatest health problem. The project will deliver new, more realistic, mathematical models for a mechanistic understanding of cognitive impairment at the neuronal level. This understanding is a vital first step in targeting drugs, e.g., to influence neuronal spine properties, for preventative health care. The project will maintain international collaborations, between applied mathematicians at UNSW, Sydney and biomathematicians and neuroscientists at Mount Sinai School of Medicine, New York, providing ongoing training opportunities for Australian scientists in this cutting edge biomathematical research.Read moreRead less
A new generation of fractals: theory, computation, and applications particularly to digital imaging. The project develops the mathematical and algorithmic foundations of superfractals and applies these results to a number of different areas, including in particular, digital imaging. For example, the ``third generation'' of mobile communications (3G), combines wireless mobile technology with high data transmission capacities. Currently the requirement for extensive bandwidth is a problem for e ....A new generation of fractals: theory, computation, and applications particularly to digital imaging. The project develops the mathematical and algorithmic foundations of superfractals and applies these results to a number of different areas, including in particular, digital imaging. For example, the ``third generation'' of mobile communications (3G), combines wireless mobile technology with high data transmission capacities. Currently the requirement for extensive bandwidth is a problem for efficient use. Superfractals and the associated colouring algorithm could be used to develop a new system to produce synthetic content for wireless devices that would require only low bandwidth.Read moreRead less
Diffusion driven pattern formation and signal propagation in spatially complex excitable media. A basic understanding of the mechanisms for pattern formation, from the spots on leopards to electrical signalling of neurons, has been achieved through reaction-diffusion equations. However to obtain a complete understanding, which is vital for many applications, it is necessary to modify this mathematical model to incorporate spatial complexities in the underlying media. This project will develop ....Diffusion driven pattern formation and signal propagation in spatially complex excitable media. A basic understanding of the mechanisms for pattern formation, from the spots on leopards to electrical signalling of neurons, has been achieved through reaction-diffusion equations. However to obtain a complete understanding, which is vital for many applications, it is necessary to modify this mathematical model to incorporate spatial complexities in the underlying media. This project will develop a fractional calculus framework for pattern formation, including signal propagation, in spatially complex and excitable media. In a particular application we will model the way in which the signalling properties of neurons depend critically on their spatial complexity.Read moreRead less