'Fixed points': extending and deepening our understanding of mathematical and computational aspects of game theory. This work will extend and deepen our understanding of mathematical and computational aspects of game theory. It will produce computer code embodying new methods of solving systems of nonlinear equations, which is useful in many areas of applied research in economics, in other disciplines such as chemistry, and potentially in the analysis of business operations. The project will a ....'Fixed points': extending and deepening our understanding of mathematical and computational aspects of game theory. This work will extend and deepen our understanding of mathematical and computational aspects of game theory. It will produce computer code embodying new methods of solving systems of nonlinear equations, which is useful in many areas of applied research in economics, in other disciplines such as chemistry, and potentially in the analysis of business operations. The project will also deepen our understanding of the underlying mathematics of such systems, and of other mathematical foundations of economic research. One application will be a new measure of the relative power resulting from voting rules. Such measures assist the design of democratic institutions by allowing the designer to assess the fairness of the outcomes they produce.Read moreRead less
A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will d ....A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will develop, whilst focused on heart tissue, will have broader applicability, and may underpin advancements in other disciplines. Finally, we expect that the software solutions and infrastructure will have both commercial and strategic value in their own right.Read moreRead less
Tractable topological computing: Escaping the hardness trap. Computational topology is a young and energetic field that uses computers to solve complex geometric problems driven by pure mathematics, and with diverse applications in biology, signal processing and data mining. A major barrier is that many of these problems are thought to be fundamentally and intractably hard. This project aims to defy such barriers for typical real-world inputs by fusing geometric techniques with technologies from ....Tractable topological computing: Escaping the hardness trap. Computational topology is a young and energetic field that uses computers to solve complex geometric problems driven by pure mathematics, and with diverse applications in biology, signal processing and data mining. A major barrier is that many of these problems are thought to be fundamentally and intractably hard. This project aims to defy such barriers for typical real-world inputs by fusing geometric techniques with technologies from the field of parameterised complexity, creating powerful, practical solutions for these problems. It is expected to shed much-needed light on the vast and puzzling gap between theory and practice, and give researchers fast new software tools for large-scale experimentation and cutting-edge computer proofs.Read moreRead less
Algorithms and computation in four-dimensional topology. This project will establish Australia as a world leader in computational topology, particularly in the all-important areas of topology in three and four dimensions. In four dimensions this work will be truly groundbreaking; until now the field has seen little development due to the complexity of the algorithms and computations required, and the applicant is in the unique position of having the necessary tools to make significant progress ....Algorithms and computation in four-dimensional topology. This project will establish Australia as a world leader in computational topology, particularly in the all-important areas of topology in three and four dimensions. In four dimensions this work will be truly groundbreaking; until now the field has seen little development due to the complexity of the algorithms and computations required, and the applicant is in the unique position of having the necessary tools to make significant progress in a feasible time frame. In three dimensions this project will strengthen the distinguished computational topology community in Melbourne, led by pioneers such as Rubinstein, Goodman, Hodgson as well as the applicant himself.Read moreRead less
The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the ....The prediction of sleep/wake behaviour based on physiological and social factors. The prevalence of shiftwork has increased in Australia over the last few decades. Shiftworkers obtain less sleep, have greater difficulty maintaining good relationships, have poorer health, and are more likely to be injured at work than others. Using the largest dataset of its kind, we will substantially contribute to understanding the relationships between work hours, sleep, performance and safety. Ultimately, the project will answer a question critical to workplace safety - how much time off between shifts is needed to be alert and safe at work? The project will also produce tools to help industry design fatigue-friendly rosters, improving the safety, productivity and general well-being of shiftworkers in Australia and overseas.Read moreRead less
Generic complexity in computational topology: breaking through the bottlenecks. The project will focus on key computational problems in three-dimensional topology, with the aims of illuminating the theoretical limitations of such problems, developing new computational tools for solving them, and applying these tools to a variety of applications. The project will generate theoretical research, practical software, and rich experimental data.
Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary geneti ....Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary genetics and dynamics of virus populations in order to understand how to control epidemics, develop vaccines and design drugs. The research program is designed to provide new computational modelling tools for this purpose, which may have wider applications as well.
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