A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interac ....A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering. Read moreRead less
Laser-based sensing, measurement and control of multi-axis flexure-based mechanisms for nano manipulations. The project aims to investigate fundamental issues in measurement, design, optimisation, and control of multi-axis flexure-based nano manipulators. It aims to establish novel sensing methodologies for position and orientation measurements and feedback, and advanced control techniques for nano manipulation in view of actuators’ nonlinearities, interferences among motion axes, and external d ....Laser-based sensing, measurement and control of multi-axis flexure-based mechanisms for nano manipulations. The project aims to investigate fundamental issues in measurement, design, optimisation, and control of multi-axis flexure-based nano manipulators. It aims to establish novel sensing methodologies for position and orientation measurements and feedback, and advanced control techniques for nano manipulation in view of actuators’ nonlinearities, interferences among motion axes, and external disturbances. The research is significant as such nano manipulators and methodologies represent the building blocks for many future scientific and engineering nano manipulation systems. The project will establish new knowledge, methodologies, and instrumentations for measurement, characterisation and control of multi-axis flexure-based nano manipulators.Read moreRead less
Robotic microsurgery: intra-operative measurement, modelling and micromanipulation control. This research will significantly improve microsurgery and minimally invasive surgery techniques, and further produce important benefits to medicine and healthcare. The project will also open new domains in the capabilities of modelling and control of complex systems with significant impact and benefits to numerous science and engineering practices.
Integrity prediction of ground precision surfaces. This project aims to establish a new approach to enable a reliable and accurate prediction of precision surface grinding. Precision grinding is often the final step in the manufacturing chains for a broad range of metal, ceramic, optical glass and semiconductor components, which must have ultra-high surface integrity and accurate dimensions. To date, the surface integrity of a ground component cannot be predicted due to the involvement of many r ....Integrity prediction of ground precision surfaces. This project aims to establish a new approach to enable a reliable and accurate prediction of precision surface grinding. Precision grinding is often the final step in the manufacturing chains for a broad range of metal, ceramic, optical glass and semiconductor components, which must have ultra-high surface integrity and accurate dimensions. To date, the surface integrity of a ground component cannot be predicted due to the involvement of many random factors and variables in a precision surface grinding process, resulting in high failure rates and processes requiring repeated surface measurements. The novel approach for surface integrity prediction developed by this project will make a vital step forward in advancing the discipline of precision surfacing, establish a new knowledge base and bring about significant technological impacts to the manufacturing industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100016
Funder
Australian Research Council
Funding Amount
$490,000.00
Summary
Multi-scale fabrication facility for complex three-dimensional surface generation from nano to macro dimensions. This facility will support advances in the manufacturing of free-form surfaces with submicron features. Its unique characteristics, such as the universal profiling ability and nanometre accuracy across large dimensions, will enable many science and engineering innovations which are presently impossible to be realised in Australia.
An integral approach enabling the defect-free manufacture of microlens arrays. Free-form microlens arrays are of central importance to the advancement of science and frontier technologies such as electronics, optics, telecommunication, biotechnology, medical surgery, energy generation, agriculture, resource exploration, environment protection and security. Using an integral approach coupling processing-microstructure-property modelling, multi-scale mechanics and damage-free mould development. Th ....An integral approach enabling the defect-free manufacture of microlens arrays. Free-form microlens arrays are of central importance to the advancement of science and frontier technologies such as electronics, optics, telecommunication, biotechnology, medical surgery, energy generation, agriculture, resource exploration, environment protection and security. Using an integral approach coupling processing-microstructure-property modelling, multi-scale mechanics and damage-free mould development. This research project will establish novel theories and technologies for the defect-free manufacture of microlens arrays. The research outcomes will lay the foundation for defect-free fabrication of a wide class of high-integrity systems.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101402
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Advanced laser micromachining with femtosecond vector beams. This project is aimed at developing a new method for ultra-precision laser micromachining and dissection of biological tissues using femtosecond vector beams. The capability of these unconventional laser beams to process different materials with unsurpassed precision and efficiency offers significant economic and clinical benefits.