A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interac ....A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering. Read moreRead less
Modular microfluidic platform for mimicking multi-organ system interactions. This project aims to develop a novel, modular microfluidic platform that overcomes current limitations of integrated systems in synchronising multi-tissue culture, imaging and operational complexity. Understanding multi-organ systemic crosstalk in human health and diseases demands dynamic culture systems that can mimic such interactions. This project will deliver a first-in-class platform technology and establish intern ....Modular microfluidic platform for mimicking multi-organ system interactions. This project aims to develop a novel, modular microfluidic platform that overcomes current limitations of integrated systems in synchronising multi-tissue culture, imaging and operational complexity. Understanding multi-organ systemic crosstalk in human health and diseases demands dynamic culture systems that can mimic such interactions. This project will deliver a first-in-class platform technology and establish international and disciplinary collaborations to develop different tissue and engineering modules relevant to applications in systemic nanotoxicology, drug bioactivation and chronic diseases. This will provide the cornerstone technology to develop a new generation of disease models and therapeutics targeting interaction dysfunctions.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100024
Funder
Australian Research Council
Funding Amount
$2,799,251.00
Summary
ARC Research Hub for Advanced Manufacturing of Medical Devices. ARC Research Hub for Advanced Manufacturing of Personalised Medical Devices. The project aims to transform Australia’s $10.8 billion medical technology sector by developing cost competitive technologies for the rapid production of personalised devices for Endovascular Aneurysm Repair (EVAR). To ensure the Australian industry remains globally competitive, this hub seeks to concurrently develop materials, technologies and flexible man ....ARC Research Hub for Advanced Manufacturing of Medical Devices. ARC Research Hub for Advanced Manufacturing of Personalised Medical Devices. The project aims to transform Australia’s $10.8 billion medical technology sector by developing cost competitive technologies for the rapid production of personalised devices for Endovascular Aneurysm Repair (EVAR). To ensure the Australian industry remains globally competitive, this hub seeks to concurrently develop materials, technologies and flexible manufacturing processes. The intended research outcomes include more efficient design and manufacturing processes and a new range of EVAR products generating increased market share and higher workforce capability. The resulting impacts should be better health outcomes, job creation and providing SMEs with new technologies and skills that can be transferred to the manufacture of products for other sectors.Read moreRead less
Additive manufacturing wear-resistant products for erosive environments. Additive manufacturing wear-resistant products for erosive environments. This project aims to develop technology to manufacture large scale, wear resistant components, involving new materials, computer-aided-design and direct hybrid manufacturing comprising laser additive and machining processes. The technology could produce more wear resistant components, using new iron-based powders, designed mesoscale graded structures a ....Additive manufacturing wear-resistant products for erosive environments. Additive manufacturing wear-resistant products for erosive environments. This project aims to develop technology to manufacture large scale, wear resistant components, involving new materials, computer-aided-design and direct hybrid manufacturing comprising laser additive and machining processes. The technology could produce more wear resistant components, using new iron-based powders, designed mesoscale graded structures and microscale reinforcing phases of appropriate morphology and size. The proposed approach is expected to lead to lower cost manufacturing mining products which perform better and have a lower environmental footprint, and more competitive Australian mining manufacturing operations.Read moreRead less
Micro-roll forming of metal bipolar plates for fuel cells. This project aims to develop a novel forming technology for the production of metal bipolar plates for fuel cells: micro-roll forming. This poses a number of challenges particularly due to the low material thickness to be formed. These challenges include the development of advanced models that account for size effects in the process and represent the unique deformation conditions and material fracture behaviour. The project plans to prod ....Micro-roll forming of metal bipolar plates for fuel cells. This project aims to develop a novel forming technology for the production of metal bipolar plates for fuel cells: micro-roll forming. This poses a number of challenges particularly due to the low material thickness to be formed. These challenges include the development of advanced models that account for size effects in the process and represent the unique deformation conditions and material fracture behaviour. The project plans to produce prototypes and to compare part complexity with that achievable by conventional micro stamping. The intended outcome of the project includes advanced computer models for process design and the new micro-forming technology validated through extensive laboratory and plant trials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100057
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Australian Stress Engineering Facility. This project aims to radically enhance the Australian capability for residual stress measurements and damage analysis. This project is expected to revolutionise stress engineering research in Australia by providing access to a state-of-the-art measurement capability that will enable on-site measurements at manufacturing plants and in laboratories. Expected outcomes of this project include the development and optimisation of advanced manufacturing and maint ....Australian Stress Engineering Facility. This project aims to radically enhance the Australian capability for residual stress measurements and damage analysis. This project is expected to revolutionise stress engineering research in Australia by providing access to a state-of-the-art measurement capability that will enable on-site measurements at manufacturing plants and in laboratories. Expected outcomes of this project include the development and optimisation of advanced manufacturing and maintenance technologies for civil engineering structures. This should provide significant benefits in safety, reliability and economic impact to Australian researchers in academia and industry across manufacturing, civil, transport, defence and medical sectors.Read moreRead less
Segmental fibres having periodically-repeating multicomponent segments from T-junction microfluidic electrospinning. Segmental fibres, which have periodically-repeating multi-component segments along their length, represent a new fibre type offering enormous potential in creating new fibre functions. The present work aims to develop a technical platform to prepare segmental fibres and new knowledge on how the fibre segments contribute to the property, functionality and inter-fibrous interaction ....Segmental fibres having periodically-repeating multicomponent segments from T-junction microfluidic electrospinning. Segmental fibres, which have periodically-repeating multi-component segments along their length, represent a new fibre type offering enormous potential in creating new fibre functions. The present work aims to develop a technical platform to prepare segmental fibres and new knowledge on how the fibre segments contribute to the property, functionality and inter-fibrous interaction of fibres. This will be achieved using a special microfluidic electrospinning technique. The segmental fibres developed will be useful for development of various new functional fibres for diverse applications. Read moreRead less
Cleaning of tough paints on advanced composites using laser technologies. This project researches fundamental knowledge and algorithms to underpin the deployment of a novel ablation technology using pulsed lasers to remove paints, in particular tough paints, from surfaces of advanced composite structures, e.g. airframes and turbine blades. It establishes thermal mechanical models to describe ablation mechanisms of pulsed laser removal of the paint using both IR and UV bands. Optimal processing p ....Cleaning of tough paints on advanced composites using laser technologies. This project researches fundamental knowledge and algorithms to underpin the deployment of a novel ablation technology using pulsed lasers to remove paints, in particular tough paints, from surfaces of advanced composite structures, e.g. airframes and turbine blades. It establishes thermal mechanical models to describe ablation mechanisms of pulsed laser removal of the paint using both IR and UV bands. Optimal processing protocols to clean paints with different properties, without damaging the underlying composites, will be determined and demonstrated. It meets a cleaning technology need for this paint-on-composites material system to support retrofitting and re-manufacturing in industry. These are crucial industry requirements. Read moreRead less
Superwettability effects on oil-mist coalescing fibrous filters. This project aims to provide new knowledge about how to use surface engineering techniques to produce highly efficient, energy-saving fibrous filters for separating oil mists from air streams. The focus is to address the challenge of the low efficiency of current generation coalescing filters for removal of oil mists smaller than one micrometre. The project will result in new methods to precisely control fibre surface wettability a ....Superwettability effects on oil-mist coalescing fibrous filters. This project aims to provide new knowledge about how to use surface engineering techniques to produce highly efficient, energy-saving fibrous filters for separating oil mists from air streams. The focus is to address the challenge of the low efficiency of current generation coalescing filters for removal of oil mists smaller than one micrometre. The project will result in new methods to precisely control fibre surface wettability and oil drainage within fibrous filters. The new knowledge and coalescing filters developed will benefit scientific and industrial fields including metal processing, automotive, engineering and manufacturing, electronics, food, hospital, mining, pharmaceuticals and energy generation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100688
Funder
Australian Research Council
Funding Amount
$336,446.00
Summary
Nanosensors in artificial cochlea for natural hearing. This project aims to develop a miniaturised and implantable cochlear that closely mimics the human auditory system by utilising advanced microfabrication techniques. This project expects to generate new knowledge in engineering hearing and vestibular hair cells and also on tonotopic organisation of cochlear. Expected outcomes include study of auditory hair cells and development of implantable ear-on-a-chip devices. This project is expected t ....Nanosensors in artificial cochlea for natural hearing. This project aims to develop a miniaturised and implantable cochlear that closely mimics the human auditory system by utilising advanced microfabrication techniques. This project expects to generate new knowledge in engineering hearing and vestibular hair cells and also on tonotopic organisation of cochlear. Expected outcomes include study of auditory hair cells and development of implantable ear-on-a-chip devices. This project is expected to enable low-cost production of highly engineered implant cochlear with great potential for commercialisation.Read moreRead less