A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interac ....A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering. Read moreRead less
Modular microfluidic platform for mimicking multi-organ system interactions. This project aims to develop a novel, modular microfluidic platform that overcomes current limitations of integrated systems in synchronising multi-tissue culture, imaging and operational complexity. Understanding multi-organ systemic crosstalk in human health and diseases demands dynamic culture systems that can mimic such interactions. This project will deliver a first-in-class platform technology and establish intern ....Modular microfluidic platform for mimicking multi-organ system interactions. This project aims to develop a novel, modular microfluidic platform that overcomes current limitations of integrated systems in synchronising multi-tissue culture, imaging and operational complexity. Understanding multi-organ systemic crosstalk in human health and diseases demands dynamic culture systems that can mimic such interactions. This project will deliver a first-in-class platform technology and establish international and disciplinary collaborations to develop different tissue and engineering modules relevant to applications in systemic nanotoxicology, drug bioactivation and chronic diseases. This will provide the cornerstone technology to develop a new generation of disease models and therapeutics targeting interaction dysfunctions.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100024
Funder
Australian Research Council
Funding Amount
$2,799,251.00
Summary
ARC Research Hub for Advanced Manufacturing of Medical Devices. ARC Research Hub for Advanced Manufacturing of Personalised Medical Devices. The project aims to transform Australia’s $10.8 billion medical technology sector by developing cost competitive technologies for the rapid production of personalised devices for Endovascular Aneurysm Repair (EVAR). To ensure the Australian industry remains globally competitive, this hub seeks to concurrently develop materials, technologies and flexible man ....ARC Research Hub for Advanced Manufacturing of Medical Devices. ARC Research Hub for Advanced Manufacturing of Personalised Medical Devices. The project aims to transform Australia’s $10.8 billion medical technology sector by developing cost competitive technologies for the rapid production of personalised devices for Endovascular Aneurysm Repair (EVAR). To ensure the Australian industry remains globally competitive, this hub seeks to concurrently develop materials, technologies and flexible manufacturing processes. The intended research outcomes include more efficient design and manufacturing processes and a new range of EVAR products generating increased market share and higher workforce capability. The resulting impacts should be better health outcomes, job creation and providing SMEs with new technologies and skills that can be transferred to the manufacture of products for other sectors.Read moreRead less
New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry suppl ....New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry supply and sales network. This project seeks to identify and harness the key material-product attributes required to develop and implement new, lead-free alloy alternatives that meet health-compliance, production and commercial viability, that offer benefits across the industry network and health benefits to society.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC180100008
Funder
Australian Research Council
Funding Amount
$3,981,223.00
Summary
ARC Training Centre for Multiscale 3D Imaging, Modelling and Manufacturing. The ARC Training Centre for Multiscale 3D Imaging, Modelling and Manufacturing aims to connect the detailed microscopic characteristics of materials with their macroscopic properties and design characteristics of natural and manufactured structures. It will train a new generation of researchers and practitioners in the emerging discipline of Digital Materials. The approach allows optimisation at all scales, enabling cost ....ARC Training Centre for Multiscale 3D Imaging, Modelling and Manufacturing. The ARC Training Centre for Multiscale 3D Imaging, Modelling and Manufacturing aims to connect the detailed microscopic characteristics of materials with their macroscopic properties and design characteristics of natural and manufactured structures. It will train a new generation of researchers and practitioners in the emerging discipline of Digital Materials. The approach allows optimisation at all scales, enabling cost reductions and performance enhancements in key industries, including Oil, Gas and Energy Resources, Medical Technologies, and Advanced Manufacturing. The Centre expects to reduce the time needed in the prototyping cycle and product development, increasing industry’s capacity for accelerated innovation. The developments will build world-class Australian capabilities for developing high-value scaleable production of bespoke products and optimised process design.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC200100001
Funder
Australian Research Council
Funding Amount
$4,879,415.00
Summary
ARC Training Centre for Collaborative Robotics in Advanced Manufacturing. The Centre aims to build the human and technical capability Australia needs to underpin our global competitiveness in advanced manufacturing. The Centre will unite manufacturing businesses, including SMEs, and universities to develop collaborative robotics applications which combine the strengths of humans and robots in shared work environments. The Centre will train researchers, engineers, technologists and manufacturing ....ARC Training Centre for Collaborative Robotics in Advanced Manufacturing. The Centre aims to build the human and technical capability Australia needs to underpin our global competitiveness in advanced manufacturing. The Centre will unite manufacturing businesses, including SMEs, and universities to develop collaborative robotics applications which combine the strengths of humans and robots in shared work environments. The Centre will train researchers, engineers, technologists and manufacturing leaders with the expertise industry needs to boost safety, quality assurance, production efficiency, and workforce readiness. The intended outcome is to support Australian manufacturers to shift toward higher-potential markets, compete globally and attract and retain a digitally-capable workforce for the future.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC180100005
Funder
Australian Research Council
Funding Amount
$4,889,410.00
Summary
ARC Training Centre in Surface Engineering for Advanced Materials. The ARC Training Centre in Surface Engineering for Advanced Materials aims to provide pathways for job creation and a high quality workforce in manufacturing. Surface engineering for advanced materials is a core need in all manufacturing sectors and controls the efficiency, productivity and sustainability of Australian industry. This Centre will integrate industry-university cooperation for applied training within an industrial s ....ARC Training Centre in Surface Engineering for Advanced Materials. The ARC Training Centre in Surface Engineering for Advanced Materials aims to provide pathways for job creation and a high quality workforce in manufacturing. Surface engineering for advanced materials is a core need in all manufacturing sectors and controls the efficiency, productivity and sustainability of Australian industry. This Centre will integrate industry-university cooperation for applied training within an industrial setting and will cover a spectrum of applications ranging from thin films to thick coatings and additive layered materials. The Centre will pursue outcomes that are reflected in terms of industry-fit researchers and deliver commercial benefits for industry.Read moreRead less
A new lapping process for difficult-to-machine brittle materials. This project aims to address a timely bottleneck issue in the conventional lapping of difficult-to-machine optoelectronic brittle materials. An innovative chemically enhanced lapping technology for fabricating such materials is expected to reduce machined subsurface damage. This is significant because it would shorten the subsequent finishing process and minimise the manufacturing cost. Intended outcomes from this project also inc ....A new lapping process for difficult-to-machine brittle materials. This project aims to address a timely bottleneck issue in the conventional lapping of difficult-to-machine optoelectronic brittle materials. An innovative chemically enhanced lapping technology for fabricating such materials is expected to reduce machined subsurface damage. This is significant because it would shorten the subsequent finishing process and minimise the manufacturing cost. Intended outcomes from this project also include an advanced machining theory and innovations in material removal characterisation. This breakthrough technology should benefit the design and fabrication of high performance electronic devices for energy, medicine and communication sectors with considerable impact on the Australian economy.Read moreRead less
Ductile grinding mechanism and technology of brittle single crystals. This project aims to develop a fundamental understanding of the removal mechanics of emerging brittle single crystals under grinding-induced loading. A successful outcome will not only develop a new theoretical model for predicting the ductile removal regime of this class of difficult-to-machine materials, but their cost-effective ductile grinding processes will also be generated. It will address a longstanding bottleneck prod ....Ductile grinding mechanism and technology of brittle single crystals. This project aims to develop a fundamental understanding of the removal mechanics of emerging brittle single crystals under grinding-induced loading. A successful outcome will not only develop a new theoretical model for predicting the ductile removal regime of this class of difficult-to-machine materials, but their cost-effective ductile grinding processes will also be generated. It will address a longstanding bottleneck productivity issue in advanced manufacturing. The breakthrough technology developed in the project is expected to significantly benefit a number of industrial sectors for the fabrication of more affordable high-performance devices including mobile phones, light-emitting diodes, solar cells, sensors, and laser systems.Read moreRead less