A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interac ....A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering. Read moreRead less
Characterization, modelling and control for robotic thermal ablation. This project aims to study the fundamental issues in robotic-assisted minimally invasive thermal ablation, an important therapy for patients with cancer. It aims to establish advanced characterisation and modelling methodologies for thermomechanical behaviours of soft tissues, together with automatic planning and precise manipulation control techniques for robotic thermal ablation therapies. The project will establish new know ....Characterization, modelling and control for robotic thermal ablation. This project aims to study the fundamental issues in robotic-assisted minimally invasive thermal ablation, an important therapy for patients with cancer. It aims to establish advanced characterisation and modelling methodologies for thermomechanical behaviours of soft tissues, together with automatic planning and precise manipulation control techniques for robotic thermal ablation therapies. The project will establish new knowledge and instrumentation for robotic-assisted thermal ablation and minimally invasive surgery. The outcomes of this project will produce important benefits to medicine, healthcare and medical technology industry, and further consolidate Australia’s position in innovative technologies and research and development of advanced healthcare systems and instruments.Read moreRead less
Cleaning of tough paints on advanced composites using laser technologies. This project researches fundamental knowledge and algorithms to underpin the deployment of a novel ablation technology using pulsed lasers to remove paints, in particular tough paints, from surfaces of advanced composite structures, e.g. airframes and turbine blades. It establishes thermal mechanical models to describe ablation mechanisms of pulsed laser removal of the paint using both IR and UV bands. Optimal processing p ....Cleaning of tough paints on advanced composites using laser technologies. This project researches fundamental knowledge and algorithms to underpin the deployment of a novel ablation technology using pulsed lasers to remove paints, in particular tough paints, from surfaces of advanced composite structures, e.g. airframes and turbine blades. It establishes thermal mechanical models to describe ablation mechanisms of pulsed laser removal of the paint using both IR and UV bands. Optimal processing protocols to clean paints with different properties, without damaging the underlying composites, will be determined and demonstrated. It meets a cleaning technology need for this paint-on-composites material system to support retrofitting and re-manufacturing in industry. These are crucial industry requirements. Read moreRead less
Superwettability effects on oil-mist coalescing fibrous filters. This project aims to provide new knowledge about how to use surface engineering techniques to produce highly efficient, energy-saving fibrous filters for separating oil mists from air streams. The focus is to address the challenge of the low efficiency of current generation coalescing filters for removal of oil mists smaller than one micrometre. The project will result in new methods to precisely control fibre surface wettability a ....Superwettability effects on oil-mist coalescing fibrous filters. This project aims to provide new knowledge about how to use surface engineering techniques to produce highly efficient, energy-saving fibrous filters for separating oil mists from air streams. The focus is to address the challenge of the low efficiency of current generation coalescing filters for removal of oil mists smaller than one micrometre. The project will result in new methods to precisely control fibre surface wettability and oil drainage within fibrous filters. The new knowledge and coalescing filters developed will benefit scientific and industrial fields including metal processing, automotive, engineering and manufacturing, electronics, food, hospital, mining, pharmaceuticals and energy generation.Read moreRead less
A new lapping process for difficult-to-machine brittle materials. This project aims to address a timely bottleneck issue in the conventional lapping of difficult-to-machine optoelectronic brittle materials. An innovative chemically enhanced lapping technology for fabricating such materials is expected to reduce machined subsurface damage. This is significant because it would shorten the subsequent finishing process and minimise the manufacturing cost. Intended outcomes from this project also inc ....A new lapping process for difficult-to-machine brittle materials. This project aims to address a timely bottleneck issue in the conventional lapping of difficult-to-machine optoelectronic brittle materials. An innovative chemically enhanced lapping technology for fabricating such materials is expected to reduce machined subsurface damage. This is significant because it would shorten the subsequent finishing process and minimise the manufacturing cost. Intended outcomes from this project also include an advanced machining theory and innovations in material removal characterisation. This breakthrough technology should benefit the design and fabrication of high performance electronic devices for energy, medicine and communication sectors with considerable impact on the Australian economy.Read moreRead less
Mechanics of the shape of thin strip with varying thickness. This project aims to develop an innovative technology for the production of thin strip with controlled varying longitudinal thickness and shape. The project will propose a new thin strip rolling theory and strip shape control strategy providing an improved understanding of the mechanics of manufacturing thin strips with varying longitudinal thickness. The technology to manufacture rolled products with varying thickness for lightweight ....Mechanics of the shape of thin strip with varying thickness. This project aims to develop an innovative technology for the production of thin strip with controlled varying longitudinal thickness and shape. The project will propose a new thin strip rolling theory and strip shape control strategy providing an improved understanding of the mechanics of manufacturing thin strips with varying longitudinal thickness. The technology to manufacture rolled products with varying thickness for lightweight structures is in significant demand for the automotive, aerospace and electronics industries to reduce weight through optimum strip thickness and minimum joints. The benefits will include reduced weight, fuel consumption and construction time of automobiles and aircraft when the developed novel thin strip products are used, and therefore reducing manufacturing costs and negative environmental impacts.Read moreRead less
Mechanisms and Platforms for Acoustomicrofluidic Intracellular Delivery . This project aims to advance a novel platform to facilitate faster and more effective molecular transport into cells as a means for enhancing cell engineering. Besides elucidating the fundamental physicochemical and biological mechanisms underpinning this new method of intracellular transport through a combination of theoretical modelling and advanced imaging and neutron diffraction, the project aims to show the scalabilit ....Mechanisms and Platforms for Acoustomicrofluidic Intracellular Delivery . This project aims to advance a novel platform to facilitate faster and more effective molecular transport into cells as a means for enhancing cell engineering. Besides elucidating the fundamental physicochemical and biological mechanisms underpinning this new method of intracellular transport through a combination of theoretical modelling and advanced imaging and neutron diffraction, the project aims to show the scalability of the technology for high throughput processing to handle the large cell numbers typically required for doses to be effective in practice. Given recent breakthroughs in cell therapies, it is expected that translation of the technology in the longer term will improve treatments for cancer and other infectious diseases.Read moreRead less
Designed to last: novel gradient coatings for extreme environments. Hard coatings are frequently applied to equipment operating in harsh environments. Often such coatings are highly brittle and so fragile under stress, especially at high temperatures or in corrosive environments. Premature failure can affect safety and lead to negative economic and environmental consequences. The objective of this project is to combine bioinspired microstructural design with an emerging alloying concept to produ ....Designed to last: novel gradient coatings for extreme environments. Hard coatings are frequently applied to equipment operating in harsh environments. Often such coatings are highly brittle and so fragile under stress, especially at high temperatures or in corrosive environments. Premature failure can affect safety and lead to negative economic and environmental consequences. The objective of this project is to combine bioinspired microstructural design with an emerging alloying concept to produce a breakthrough in the development of engineering coatings; for example, overcoming the long standing trade-off between hardness and toughness. Such an innovative coating is expected to be highly durable in extreme conditions, and in so doing will help transform manufacturing, mining and desalination industries.Read moreRead less
High speed multi-channel discharge machining of difficult-to-cut materials. This project aims to develop a novel approach to high speed machining of difficult-to-cut materials by resolving the contradictory surface quality and machining efficiency problem with a new theory. It is expected to advance the fundamental knowledge of electrical machining. The outcomes are new machining theories, novel methods and models of using multiple low energy sparks which occur nearly simultaneously for high spe ....High speed multi-channel discharge machining of difficult-to-cut materials. This project aims to develop a novel approach to high speed machining of difficult-to-cut materials by resolving the contradictory surface quality and machining efficiency problem with a new theory. It is expected to advance the fundamental knowledge of electrical machining. The outcomes are new machining theories, novel methods and models of using multiple low energy sparks which occur nearly simultaneously for high speed machining of a wide range of advanced materials. It should significantly increase machining speed and thus dramatically reduce the costs of producing products such as titanium medical implants, alloyed engine components and new cutting tools which are vital for the biomaterials, aerospace and manufacturing industries.Read moreRead less
Ductile grinding mechanism and technology of brittle single crystals. This project aims to develop a fundamental understanding of the removal mechanics of emerging brittle single crystals under grinding-induced loading. A successful outcome will not only develop a new theoretical model for predicting the ductile removal regime of this class of difficult-to-machine materials, but their cost-effective ductile grinding processes will also be generated. It will address a longstanding bottleneck prod ....Ductile grinding mechanism and technology of brittle single crystals. This project aims to develop a fundamental understanding of the removal mechanics of emerging brittle single crystals under grinding-induced loading. A successful outcome will not only develop a new theoretical model for predicting the ductile removal regime of this class of difficult-to-machine materials, but their cost-effective ductile grinding processes will also be generated. It will address a longstanding bottleneck productivity issue in advanced manufacturing. The breakthrough technology developed in the project is expected to significantly benefit a number of industrial sectors for the fabrication of more affordable high-performance devices including mobile phones, light-emitting diodes, solar cells, sensors, and laser systems.Read moreRead less