Peptide-based Star Polymers for Improved Biointeraction and Targeted Anticancer Therapies. The aim of this project is to develop peptide-based star polymer nanocarriers for targeted drug delivery to cancer stem cells which integrate aptamer targeting technology and biointeraction studies with blood plasma fluid. The significance of this research is it pioneers the development of a drug delivery system that minimises plasma opsonization through understanding polymer-plasma interactions, which in ....Peptide-based Star Polymers for Improved Biointeraction and Targeted Anticancer Therapies. The aim of this project is to develop peptide-based star polymer nanocarriers for targeted drug delivery to cancer stem cells which integrate aptamer targeting technology and biointeraction studies with blood plasma fluid. The significance of this research is it pioneers the development of a drug delivery system that minimises plasma opsonization through understanding polymer-plasma interactions, which in turn increases tumour specificity and cell internalisation through incorporation of targeting aptamers and triggered drug release. This project will use rational design, advanced macromolecular engineering and an interdisciplinary collaboration to generate next-generation polymer therapeutics for drug delivery.Read moreRead less
Precision-Engineered Polymer Nanomaterials. Designing polymer nanoparticles that interact with or mimic biological systems represents a challenge in the field of polymer science. The project will address this challenge to deliver a quantitative and qualitative understanding linking synthetic materials and biological systems. Structurally perfect polymeric dendrimers, prepared using break through synthetic approaches and kinetic and computer modelling, are the ideal structure to introduce this fu ....Precision-Engineered Polymer Nanomaterials. Designing polymer nanoparticles that interact with or mimic biological systems represents a challenge in the field of polymer science. The project will address this challenge to deliver a quantitative and qualitative understanding linking synthetic materials and biological systems. Structurally perfect polymeric dendrimers, prepared using break through synthetic approaches and kinetic and computer modelling, are the ideal structure to introduce this function with predictable behaviour. The project will achieve tangible impacts for global communities and industries including the development of biomimetic nanodevices for smart drug delivery devices and peptide mimics.Read moreRead less
A platform for the efficient optimisation of drug delivery using cross-linked micelles and thioclick-chemistry toward better anti-cancer treatment. The delivery of albendazole - an anti-cancer drug - will be improved by encapsulating the drug into nanoparticles. State of the art polymer chemistry will be employed to generate a versatile drug delivery system. The resulting nanoparticles will be able to better control drug delivery and to enhance cellular uptake of the drug.