Single Molecule Studies of Replisomal Function. It has recently become possible to watch the copying of DNA molecules with a specialized microscope in real time. This process requires assembly of a complex molecular machine on the DNA, followed by triggering of its function, and yields exquisitely detailed information about how the machine works. In this new collaboration between scientists in Australia and the U.S.A., we will assemble these machines on single DNA molecules, watch how they work ....Single Molecule Studies of Replisomal Function. It has recently become possible to watch the copying of DNA molecules with a specialized microscope in real time. This process requires assembly of a complex molecular machine on the DNA, followed by triggering of its function, and yields exquisitely detailed information about how the machine works. In this new collaboration between scientists in Australia and the U.S.A., we will assemble these machines on single DNA molecules, watch how they work and simultaneously measure the very small forces that the machines generate. This will give Australian scientists access to a new technology for studying molecular machines.Read moreRead less
Novel hybrid agricultural-byproduct/synthetic materials. The French partners have developed a method of converting low-value agricultural by-products into commodity plastics; however, the results are too water-sensitive to be useful. This project is to develop the science for grafting water-resistant moieties to this product, using mechanistically-based techniques developed by the Sydney group. The outcome would be technology for making useful materials from agricultural by-products that are cur ....Novel hybrid agricultural-byproduct/synthetic materials. The French partners have developed a method of converting low-value agricultural by-products into commodity plastics; however, the results are too water-sensitive to be useful. This project is to develop the science for grafting water-resistant moieties to this product, using mechanistically-based techniques developed by the Sydney group. The outcome would be technology for making useful materials from agricultural by-products that are currently of very low value in Australia.Read moreRead less