Designing dendrimer-based lymphatic drug vectors as improved treatments for metastatic cancer. This project builds on areas of research strength in Australia (nanotechnology and biotechnology/biomaterials) and will add considerably to the expanding Australian expertise-base in dendrimer technology (in which it is a world leader). The project will advance the fundamental science base that underpins dendrimer design and has the potential to deliver substantial benefits in improved drug delivery an ....Designing dendrimer-based lymphatic drug vectors as improved treatments for metastatic cancer. This project builds on areas of research strength in Australia (nanotechnology and biotechnology/biomaterials) and will add considerably to the expanding Australian expertise-base in dendrimer technology (in which it is a world leader). The project will advance the fundamental science base that underpins dendrimer design and has the potential to deliver substantial benefits in improved drug delivery and therefore health outcomes for Australia. The interdisciplinary nature of this project will also result in a unique training program for the researchers involved. Such experience is in great demand in Australia where the developing biotechnology and nanotechnology industry is critically short of scientists with skills in drug delivery.Read moreRead less
A structure-based design approach to maximising targeting interactions. This project aims to build on a highly successful collaboration between the Australian biotechnology company Starpharma and Monash University, to better understand the design of next generation nanomaterials that home to specific target cells. The project seeks to capitalize on recent advances in dendrimer chemistry and protein engineering to explore the design of nanomaterials linked to engineered antibody fragments. The an ....A structure-based design approach to maximising targeting interactions. This project aims to build on a highly successful collaboration between the Australian biotechnology company Starpharma and Monash University, to better understand the design of next generation nanomaterials that home to specific target cells. The project seeks to capitalize on recent advances in dendrimer chemistry and protein engineering to explore the design of nanomaterials linked to engineered antibody fragments. The anticipated goal is attainment of exquisite, cell specific targeting affinity. Targeted nanomaterials have the potential to transform the clarity of imaging technologies; to facilitate the design of sensors and diagnostics that detect biochemical change in highly select cell populations and to revolutionise drug delivery.Read moreRead less
Nanostructured anticorrosive coating for wave energy conversion module. The project will develop new high performance anticorrosion coatings for metal structures, such as a Waverider- a patented wave energy conversion module. It will deliver a strong intellectual property position in the frontier anti-corrosion technology to Australian Industry and train young scientists in the emerging and multidisciplinary field of research.
Advanced framework materials for hydrogen storage applications. This project aims to develop new molecular materials capable of the highly efficient storage of hydrogen gas. Through an innovative interdisciplinary approach that targets the synthesis and detailed characterisation of two classes of molecular material this project expects to generate step-change advances in the understanding of how hydrogen gas uptake relates to the chemical and physical attributes of porous molecular systems. Sign ....Advanced framework materials for hydrogen storage applications. This project aims to develop new molecular materials capable of the highly efficient storage of hydrogen gas. Through an innovative interdisciplinary approach that targets the synthesis and detailed characterisation of two classes of molecular material this project expects to generate step-change advances in the understanding of how hydrogen gas uptake relates to the chemical and physical attributes of porous molecular systems. Significant anticipated outcomes and benefits include the development of new material design approaches that optimise performance across a diverse parameter space, and the generation of advanced new materials worthy of commercial development, spanning small scale mobile to large scale stationary storage applications.Read moreRead less
A study of the interrelationships between drug release and polymer biodegradation of novel drug-polymer conjugates (DPCs). This project involves a comprehensive investigation of novel polyurethane based drug-polymer conjugates. A variety of components will be scrutinised using a modular approach for assembling the drug conjugated devices, resulting in different polymer biodegradation characteristics, drug release rates and physical properties. The project aims to provide key knowledge about the ....A study of the interrelationships between drug release and polymer biodegradation of novel drug-polymer conjugates (DPCs). This project involves a comprehensive investigation of novel polyurethane based drug-polymer conjugates. A variety of components will be scrutinised using a modular approach for assembling the drug conjugated devices, resulting in different polymer biodegradation characteristics, drug release rates and physical properties. The project aims to provide key knowledge about the inter-relationships between the key elements so that each can be precisely tailored to meet the specific requirements of a particular biological site and drug. Ultimately, this study intends to lead to the production of new drug-carrier polymer devices suitable for the treatment of illnesses and diseases.Read moreRead less
Next generation high sensitivity polymeric Extreme Ultraviolet (EUV) resists. Each generation of computer we purchase has faster processors, larger memory and is smaller and cheaper than the preceding model. However the annual improvements are at risk due to inherent problems with existing technologies, so in this project we will produce technologies that will enable the next generation of energy-efficient, faster computers.
Precision luminescent solar concentrators from robust quantum dot arrays. Precision luminescent solar concentrators from robust quantum dot arrays. This project aims to make luminescent solar concentrators that can harness solar energy from surfaces not suited for conventional solar cells, such as car windows. It will design, synthesise and conduct detailed energy transfer studies of robust inorganic quantum dot arrays with fit-for-purpose precise spectral properties. Synthetic light-harvesting ....Precision luminescent solar concentrators from robust quantum dot arrays. Precision luminescent solar concentrators from robust quantum dot arrays. This project aims to make luminescent solar concentrators that can harness solar energy from surfaces not suited for conventional solar cells, such as car windows. It will design, synthesise and conduct detailed energy transfer studies of robust inorganic quantum dot arrays with fit-for-purpose precise spectral properties. Synthetic light-harvesting dye arrays have often been proposed to solve bottleneck challenges in the solar energy sector but there are issues with stability, processing and their photophysical output matching market needs. This project’s dyes are expected to create market opportunities for Australian luminescent solar concentrator technology.Read moreRead less
Bioinks that Advance 3D bioprinting of cells to the 4th dimension. The aim of this research is to provide a simple method for creating complex 3D cell cultures for in vitro cell based assays using 3D printing. A versatile polymer system as a bioink made from entirely commercially available components, will be advanced that gives a full range of soft tissue mimics and which can be dynamically change on-demand after printing of the 3D cell cultures. The latter will provide in vitro mimics of in vi ....Bioinks that Advance 3D bioprinting of cells to the 4th dimension. The aim of this research is to provide a simple method for creating complex 3D cell cultures for in vitro cell based assays using 3D printing. A versatile polymer system as a bioink made from entirely commercially available components, will be advanced that gives a full range of soft tissue mimics and which can be dynamically change on-demand after printing of the 3D cell cultures. The latter will provide in vitro mimics of in vivo events never previously possible with more realistic models of what is found in vivo. Applications are in fundamental cell biology, studying diseases and developing new drugs. The outcomes from this research will be new knowledge on designing cheap extracellular matrix mimics and high throughout 3D cell assays.Read moreRead less