Patterned assemblies of molecules on surfaces. Because of their redox and photophysical properties, artificial porphyrin systems have been designed for applications such as light-harvesting antennae, catalysts and sensors. Control of molecular orientation is required in order to construct practical devices, and in this project methods of assembling porphyrins on surfaces in well-defined patterns will be developed. Sophisticated methods will be used to characterise the films produced in these w ....Patterned assemblies of molecules on surfaces. Because of their redox and photophysical properties, artificial porphyrin systems have been designed for applications such as light-harvesting antennae, catalysts and sensors. Control of molecular orientation is required in order to construct practical devices, and in this project methods of assembling porphyrins on surfaces in well-defined patterns will be developed. Sophisticated methods will be used to characterise the films produced in these ways, in order to provide the information necessary to refine procedures and design new molecules suitable for advanced applications. Expected outcomes are new methods and architectures that can ultimately yield devices that act at the molecular level.Read moreRead less
Theoretical and computational approaches to accurately predict the structures of a unique family of circular and knotted proteins. The primary outcome will be a fundamental new knowledge on cyclotide structures and a new protein engineering method to design stabilised proteins. Because cyclotides have significantly higher stabilities than conventional proteins, they have a range of pharmaceutical and agricultural applications. Both fields of use have the potential for very great economic and soc ....Theoretical and computational approaches to accurately predict the structures of a unique family of circular and knotted proteins. The primary outcome will be a fundamental new knowledge on cyclotide structures and a new protein engineering method to design stabilised proteins. Because cyclotides have significantly higher stabilities than conventional proteins, they have a range of pharmaceutical and agricultural applications. Both fields of use have the potential for very great economic and social benefits for Australia. From a pharmaceutical perspective our computing development will greatly facilitate the design of stabilised peptide-based drugs using the cyclotide framework. Such drugs have potential sales of several billion dollars per annum and the royalty returns from successful commercialisation of IP can be substantial.Read moreRead less