Developing serial crystallography for room temperature structure & dynamics. This project aims to uncover the molecular structural dynamics of a bacterial enzyme responsible for protein folding in bacteria. This project expects to generate new knowledge to guide the development of a new type of antibacterial to circumvent antibiotic resistance. Expected outcomes of this project include new experimental, computational and simulation tools for dynamic X-ray crystallography including new capabiliti ....Developing serial crystallography for room temperature structure & dynamics. This project aims to uncover the molecular structural dynamics of a bacterial enzyme responsible for protein folding in bacteria. This project expects to generate new knowledge to guide the development of a new type of antibacterial to circumvent antibiotic resistance. Expected outcomes of this project include new experimental, computational and simulation tools for dynamic X-ray crystallography including new capabilities at the Australian Synchrotron for very small microcrystals of any biomolecule. This would provide a powerful new tool for the Australian structural biology community that should accelerate fundamental discoveries, including facilitating high-resolution structure determination of membrane proteins and drug development.Read moreRead less
Resonant tender X-ray scattering of organic semiconductors. This project aims to establish resonant tender X-ray scattering as a mature technique for unravelling the complex microstructure of organic semiconductor layers. By understanding and exploiting the resonant interaction between organic semiconductors and X-rays tuned to appropriate absorption edges, new information about the molecular packing of these materials will be obtained. The expected outcomes are new experimental methodologies an ....Resonant tender X-ray scattering of organic semiconductors. This project aims to establish resonant tender X-ray scattering as a mature technique for unravelling the complex microstructure of organic semiconductor layers. By understanding and exploiting the resonant interaction between organic semiconductors and X-rays tuned to appropriate absorption edges, new information about the molecular packing of these materials will be obtained. The expected outcomes are new experimental methodologies and analysis tools for determining the complex structure of technologically relevant materials. Benefits include understanding of the properties of solution-processed semiconductors enabling the design of high performance materials with applications in energy, electronics, lighting and health.Read moreRead less