Novel concepts to engineer low cost blood diagnostics. Novel concepts to engineer low cost blood diagnostics. This project aims to deliver the next generation of on-paper blood diagnostics: cheap, fast, easy to use, reliable, specific and robust. Transformational methods in on-paper and thread-based diagnostics could make indirect and weak blood typing possible. This project expects on-paper testing for fibrinogen to assess clotting capability could revolutionise treatment of massive blood loss. ....Novel concepts to engineer low cost blood diagnostics. Novel concepts to engineer low cost blood diagnostics. This project aims to deliver the next generation of on-paper blood diagnostics: cheap, fast, easy to use, reliable, specific and robust. Transformational methods in on-paper and thread-based diagnostics could make indirect and weak blood typing possible. This project expects on-paper testing for fibrinogen to assess clotting capability could revolutionise treatment of massive blood loss. Expected results of this project are a new class of on-paper and thread-based diagnostic tests with enhanced sensitivity, readability and lower cost, which could significantly affect trauma, rural medicine and developing nations.Read moreRead less
Synthetic phenazines for enhanced biogas production from renewable and non-renewable resources. Methane (biogas) has a large role to play in meeting the energy needs of the human race globally whilst reducing greenhouse gas emissions. Microbial communities are responsible for biogas production from non-renewable (coal) and renewable (food waste) resources. This project seeks to: increase biogas yields by redirecting electron flow towards biogas producing microbes using electrochemically active p ....Synthetic phenazines for enhanced biogas production from renewable and non-renewable resources. Methane (biogas) has a large role to play in meeting the energy needs of the human race globally whilst reducing greenhouse gas emissions. Microbial communities are responsible for biogas production from non-renewable (coal) and renewable (food waste) resources. This project seeks to: increase biogas yields by redirecting electron flow towards biogas producing microbes using electrochemically active phenazines; understand the molecular mechanism by which phenazines increase biogas yields; and, assess the environmental consequence of phenazine application to coal seam gas production and anaerobic digestion of food waste. Phenazines are likely to emerge as a safe and cost-effective technology for improved biogas generation.Read moreRead less
Industrial biotechnology for improved manufacture of medicinal alkaloids. Industrial biotechnology for improved manufacture of medicinal alkaloids. This project aims to develop a new semi-synthetic route for the manufacture of Codeine from Thebaine. Codeine is manufactured by the chemical conversion of poppy-derived Morphine, which is low yielding and environmentally unfriendly. This project will investigate and optimise two key enzymes in the biosynthetic pathway to Codeine and develop an innov ....Industrial biotechnology for improved manufacture of medicinal alkaloids. Industrial biotechnology for improved manufacture of medicinal alkaloids. This project aims to develop a new semi-synthetic route for the manufacture of Codeine from Thebaine. Codeine is manufactured by the chemical conversion of poppy-derived Morphine, which is low yielding and environmentally unfriendly. This project will investigate and optimise two key enzymes in the biosynthetic pathway to Codeine and develop an innovative bioreactor to achieve high yield. It will research industrial biotransformations, providing a greener and cheaper process for increased global access to Codeine. Australian opiate manufacturing is expected to benefit from value adding and increased flexibility introduced by a biotechnology approach.Read moreRead less
An Integrated Biotechnological Process for Production of Lactic Acid from Carbohydrate-Waste Streams by Rhizopus sp. Lactic acid is the most widely occurring multifunctional organic acid. It has enormous applications in food and food-related industries, and great potential use for production of biodegradable and biocompatible polylactate polymers. The aim of this research is to develop an innovative biotechnological process, incorporating simultaneous saccharification and fermentation, which int ....An Integrated Biotechnological Process for Production of Lactic Acid from Carbohydrate-Waste Streams by Rhizopus sp. Lactic acid is the most widely occurring multifunctional organic acid. It has enormous applications in food and food-related industries, and great potential use for production of biodegradable and biocompatible polylactate polymers. The aim of this research is to develop an innovative biotechnological process, incorporating simultaneous saccharification and fermentation, which integrates the production of lactic acid with the treatment of high strength food industry ?effluent? streams - carbohydrate waste streams. The proposed SSF process will cultivate an identified fungal Rhizopus sp strain on the waste streams, as production substrates, leading to an environmentally friendly and economically sustainable new technology for the food industry.Read moreRead less
Transport phenomena in foam fractionation. Foam fractionation has a number of immediate applications in mineral and food processing but its most exciting potential is as low cost alternative for recovering and purifying high value biosurfactants. These are materials used to stabilise interfaces in living systems, and can be used as antibiotics and antiviral agents. The affinity for biosurfactants to collect at an interface suggests that foam fractionation is an ideal process to concentrate valua ....Transport phenomena in foam fractionation. Foam fractionation has a number of immediate applications in mineral and food processing but its most exciting potential is as low cost alternative for recovering and purifying high value biosurfactants. These are materials used to stabilise interfaces in living systems, and can be used as antibiotics and antiviral agents. The affinity for biosurfactants to collect at an interface suggests that foam fractionation is an ideal process to concentrate valuable products. Clearly, a cost-effective and reliable method of enriching streams of biosurfactants will make their use even more attractive and will engender the development of more novel biomaterials, such as pepfactants.Read moreRead less
Novel enzymatic processing methods and stabilization technologies for omega-3 oils. New and existing lipases will be applied to the concentration of omega-3 lipids from fish and algal oils. The primary aim of this project is to replace current chemical processes and high temperature distillation with milder enzymatic methods, providing high quality omega-3 concentrates for food and pharmaceutical purposes. The project aims to develop new immobilisation technology to enable multiple re-use of lip ....Novel enzymatic processing methods and stabilization technologies for omega-3 oils. New and existing lipases will be applied to the concentration of omega-3 lipids from fish and algal oils. The primary aim of this project is to replace current chemical processes and high temperature distillation with milder enzymatic methods, providing high quality omega-3 concentrates for food and pharmaceutical purposes. The project aims to develop new immobilisation technology to enable multiple re-use of lipases for the cost effective production of omega-3 concentrates and to apply new microencapsulation strategies to the stabilisation of omega-3 concentrates, enabling the delivery of omega-3s and other bioactive ingredients to a range of food and beverage products.Read moreRead less
Renewable energy from carbon dioxide: Process engineering to obtain bio-oil from algae. The Stern Report (2007)[1] has called for a CO2 REDUCTION BY MORE THAN 80% in 10-20 years to prevent profound changes in the climate over coming centuries. The proposed project will capture CO2 using algae then off-set the capital investment and on-going expenses of the CO2 capture technology by creating high value products from algae (i.e. bio-diesel, livestock feed and purified water). This process aims to ....Renewable energy from carbon dioxide: Process engineering to obtain bio-oil from algae. The Stern Report (2007)[1] has called for a CO2 REDUCTION BY MORE THAN 80% in 10-20 years to prevent profound changes in the climate over coming centuries. The proposed project will capture CO2 using algae then off-set the capital investment and on-going expenses of the CO2 capture technology by creating high value products from algae (i.e. bio-diesel, livestock feed and purified water). This process aims to be independently profitable regarless of future carbon taxes or carbon trading systems. This project also investigates water purification methods and new livestock feed additives which can help reduce the effects of drought on food producers in rural and regional areas. Read moreRead less
Dissection of nodule and lateral root development in the model legume Lotus japonicus. We propose to isolate and decipher the function of plant genes involved in nodule development, with the view to extend and compare this knowledge to lateral root formation. While nodulation and lateral root formation are distinct processes, they appear to share anatomical and biochemical features. Working hypothesis is that nodule formation borrowed functions from lateral root development. Our approach impleme ....Dissection of nodule and lateral root development in the model legume Lotus japonicus. We propose to isolate and decipher the function of plant genes involved in nodule development, with the view to extend and compare this knowledge to lateral root formation. While nodulation and lateral root formation are distinct processes, they appear to share anatomical and biochemical features. Working hypothesis is that nodule formation borrowed functions from lateral root development. Our approach implements T-DNA and transposon insertional mutagenesis in the model legume Lotus japonicus. The success of this project will contribute significantly to the studies of plant-microbe interaction and plant morphogenesis.Read moreRead less
Towards the development of a novel live vaccine for the control of Glässer's disease (Haemophilus parasuis), a globally significant respiratory disease of swine. Respiratory diseases are common in intensively housed pigs, costing the Australian industry millions of dollars in lost production annually. Glässer's is a highly contagious and often fatal respiratory disease of pigs. Antibiotic therapy is expensive and often results in the emergence of antibiotic resistant organisms. There is also a t ....Towards the development of a novel live vaccine for the control of Glässer's disease (Haemophilus parasuis), a globally significant respiratory disease of swine. Respiratory diseases are common in intensively housed pigs, costing the Australian industry millions of dollars in lost production annually. Glässer's is a highly contagious and often fatal respiratory disease of pigs. Antibiotic therapy is expensive and often results in the emergence of antibiotic resistant organisms. There is also a trend to move away from the use of antibiotics in food production animals. Current vaccines are based on inactivated preparations and do not offer a high level of immune protection. Therefore, there is a great need worldwide for a live vaccine for the effective control of Glässer's disease.Read moreRead less
In situ microbial conversion of coal to methane: Biotechnology development for clean use of Australian coal. We will develop a biotechnology that uses native microorganisms to accelerate the underground conversion of coal to methane. Approximately 90% of Australia’s coal resources cannot be accessed economically using traditional mining technologies. A technology that converts coal to methane could generate an energy supply worth an estimated $60 billion, foster the development of an energy indu ....In situ microbial conversion of coal to methane: Biotechnology development for clean use of Australian coal. We will develop a biotechnology that uses native microorganisms to accelerate the underground conversion of coal to methane. Approximately 90% of Australia’s coal resources cannot be accessed economically using traditional mining technologies. A technology that converts coal to methane could generate an energy supply worth an estimated $60 billion, foster the development of an energy industry now in its infancy, and generate numerous new employment opportunities. Environmentally, methane is a cleaner burning fuel than coal, uses much less water for processing and generates the same quantity of electricity with lower CO2 emissions. This project highlights the fact that Australia’s microbial diversity is a resource we cannot afford to ignore.Read moreRead less