Novel concepts to engineer low cost blood diagnostics. Novel concepts to engineer low cost blood diagnostics. This project aims to deliver the next generation of on-paper blood diagnostics: cheap, fast, easy to use, reliable, specific and robust. Transformational methods in on-paper and thread-based diagnostics could make indirect and weak blood typing possible. This project expects on-paper testing for fibrinogen to assess clotting capability could revolutionise treatment of massive blood loss. ....Novel concepts to engineer low cost blood diagnostics. Novel concepts to engineer low cost blood diagnostics. This project aims to deliver the next generation of on-paper blood diagnostics: cheap, fast, easy to use, reliable, specific and robust. Transformational methods in on-paper and thread-based diagnostics could make indirect and weak blood typing possible. This project expects on-paper testing for fibrinogen to assess clotting capability could revolutionise treatment of massive blood loss. Expected results of this project are a new class of on-paper and thread-based diagnostic tests with enhanced sensitivity, readability and lower cost, which could significantly affect trauma, rural medicine and developing nations.Read moreRead less
Development of electrophoretic cell sorters. The aim of this research is to develop the next generation of cell sorters to scale production of viable sperm and other cell types. Our approach is to understand the factors that control the migration of cells in an electric field so that we can design large-scale devices to purify cells using electrophoretic separation. The outcomes of this research enable large-scale production of viable sperm for human and animal-assisted conception, benefiting in ....Development of electrophoretic cell sorters. The aim of this research is to develop the next generation of cell sorters to scale production of viable sperm and other cell types. Our approach is to understand the factors that control the migration of cells in an electric field so that we can design large-scale devices to purify cells using electrophoretic separation. The outcomes of this research enable large-scale production of viable sperm for human and animal-assisted conception, benefiting infertile couples and the livestock breeding industry. Successful development of an efficient cell separation technology would add significant commercial value to the Australian biomanufacturing sector. Read moreRead less
High performance bioderived hybrid fillers for rubber composite. This project aims to address a significant problem in polymer composite synthesis by production and application of high performance bioderived hybrid silica fillers from renewable biomass feedstock. The project expects to generate new knowledge in the area of advanced manufacturing using interdisciplinary approaches in biorefining, filler and composite production and characterization. Expected outcomes of this project include a mo ....High performance bioderived hybrid fillers for rubber composite. This project aims to address a significant problem in polymer composite synthesis by production and application of high performance bioderived hybrid silica fillers from renewable biomass feedstock. The project expects to generate new knowledge in the area of advanced manufacturing using interdisciplinary approaches in biorefining, filler and composite production and characterization. Expected outcomes of this project include a more sustainable filler production process for producing novel bioderived silica fillers with properties superior to commercial silica fillers. The successful implementation of this project will lead to the development of a new advanced manufacturing industry, creating jobs in regional Australia. Read moreRead less
Industrial biotechnology for improved manufacture of medicinal alkaloids. Industrial biotechnology for improved manufacture of medicinal alkaloids. This project aims to develop a new semi-synthetic route for the manufacture of Codeine from Thebaine. Codeine is manufactured by the chemical conversion of poppy-derived Morphine, which is low yielding and environmentally unfriendly. This project will investigate and optimise two key enzymes in the biosynthetic pathway to Codeine and develop an innov ....Industrial biotechnology for improved manufacture of medicinal alkaloids. Industrial biotechnology for improved manufacture of medicinal alkaloids. This project aims to develop a new semi-synthetic route for the manufacture of Codeine from Thebaine. Codeine is manufactured by the chemical conversion of poppy-derived Morphine, which is low yielding and environmentally unfriendly. This project will investigate and optimise two key enzymes in the biosynthetic pathway to Codeine and develop an innovative bioreactor to achieve high yield. It will research industrial biotransformations, providing a greener and cheaper process for increased global access to Codeine. Australian opiate manufacturing is expected to benefit from value adding and increased flexibility introduced by a biotechnology approach.Read moreRead less
Novel enzymatic processing methods and stabilization technologies for omega-3 oils. New and existing lipases will be applied to the concentration of omega-3 lipids from fish and algal oils. The primary aim of this project is to replace current chemical processes and high temperature distillation with milder enzymatic methods, providing high quality omega-3 concentrates for food and pharmaceutical purposes. The project aims to develop new immobilisation technology to enable multiple re-use of lip ....Novel enzymatic processing methods and stabilization technologies for omega-3 oils. New and existing lipases will be applied to the concentration of omega-3 lipids from fish and algal oils. The primary aim of this project is to replace current chemical processes and high temperature distillation with milder enzymatic methods, providing high quality omega-3 concentrates for food and pharmaceutical purposes. The project aims to develop new immobilisation technology to enable multiple re-use of lipases for the cost effective production of omega-3 concentrates and to apply new microencapsulation strategies to the stabilisation of omega-3 concentrates, enabling the delivery of omega-3s and other bioactive ingredients to a range of food and beverage products.Read moreRead less
Renewable energy from carbon dioxide: Process engineering to obtain bio-oil from algae. The Stern Report (2007)[1] has called for a CO2 REDUCTION BY MORE THAN 80% in 10-20 years to prevent profound changes in the climate over coming centuries. The proposed project will capture CO2 using algae then off-set the capital investment and on-going expenses of the CO2 capture technology by creating high value products from algae (i.e. bio-diesel, livestock feed and purified water). This process aims to ....Renewable energy from carbon dioxide: Process engineering to obtain bio-oil from algae. The Stern Report (2007)[1] has called for a CO2 REDUCTION BY MORE THAN 80% in 10-20 years to prevent profound changes in the climate over coming centuries. The proposed project will capture CO2 using algae then off-set the capital investment and on-going expenses of the CO2 capture technology by creating high value products from algae (i.e. bio-diesel, livestock feed and purified water). This process aims to be independently profitable regarless of future carbon taxes or carbon trading systems. This project also investigates water purification methods and new livestock feed additives which can help reduce the effects of drought on food producers in rural and regional areas. Read moreRead less
Towards the development of a novel live vaccine for the control of Glässer's disease (Haemophilus parasuis), a globally significant respiratory disease of swine. Respiratory diseases are common in intensively housed pigs, costing the Australian industry millions of dollars in lost production annually. Glässer's is a highly contagious and often fatal respiratory disease of pigs. Antibiotic therapy is expensive and often results in the emergence of antibiotic resistant organisms. There is also a t ....Towards the development of a novel live vaccine for the control of Glässer's disease (Haemophilus parasuis), a globally significant respiratory disease of swine. Respiratory diseases are common in intensively housed pigs, costing the Australian industry millions of dollars in lost production annually. Glässer's is a highly contagious and often fatal respiratory disease of pigs. Antibiotic therapy is expensive and often results in the emergence of antibiotic resistant organisms. There is also a trend to move away from the use of antibiotics in food production animals. Current vaccines are based on inactivated preparations and do not offer a high level of immune protection. Therefore, there is a great need worldwide for a live vaccine for the effective control of Glässer's disease.Read moreRead less
In situ microbial conversion of coal to methane: Biotechnology development for clean use of Australian coal. We will develop a biotechnology that uses native microorganisms to accelerate the underground conversion of coal to methane. Approximately 90% of Australia’s coal resources cannot be accessed economically using traditional mining technologies. A technology that converts coal to methane could generate an energy supply worth an estimated $60 billion, foster the development of an energy indu ....In situ microbial conversion of coal to methane: Biotechnology development for clean use of Australian coal. We will develop a biotechnology that uses native microorganisms to accelerate the underground conversion of coal to methane. Approximately 90% of Australia’s coal resources cannot be accessed economically using traditional mining technologies. A technology that converts coal to methane could generate an energy supply worth an estimated $60 billion, foster the development of an energy industry now in its infancy, and generate numerous new employment opportunities. Environmentally, methane is a cleaner burning fuel than coal, uses much less water for processing and generates the same quantity of electricity with lower CO2 emissions. This project highlights the fact that Australia’s microbial diversity is a resource we cannot afford to ignore.Read moreRead less
Evaluating the applicability of Directed Evolution to the optimisation of industrial yeast strains. The fermentation industries, particularly the wine industry, are of great economic importance to Australia. Wine exports exceed $2 billion per year. Moreover, the industry and those supporting it are major employers in regional Australia. To maintain and grow our share of the international market, Australian wine must remain competitive by increasing production efficiency, maximizing quality and k ....Evaluating the applicability of Directed Evolution to the optimisation of industrial yeast strains. The fermentation industries, particularly the wine industry, are of great economic importance to Australia. Wine exports exceed $2 billion per year. Moreover, the industry and those supporting it are major employers in regional Australia. To maintain and grow our share of the international market, Australian wine must remain competitive by increasing production efficiency, maximizing quality and keeping up with changing consumer preferences, and with minimal environmental impact. As a cornerstone to the winemaking process, the yeast is a vehicle for achieving these needs. This project will develop and evaluate a method for generation of unique yeast which are non-recombinant and which yield superior wine under modern winemaking conditions.Read moreRead less
Sustainable dollar notes and other polypropylenes from bioderived feedstocks. Fossil fuels provide us with the essential chemicals for our life style. The chemical industry recognizes limited supply and a need to reduce carbon emissions. Microbes are able to supply green chemicals (e.g. bio-ethanol), but efficiencies are often low. This project will develop microbes for the fermentative production of plastics from cane sugar.