Proteomics of the Influenza Virus for In-field Surveillance. The influenza virus continues to pose a serious health risk to Australians and remains a leading cause of death. The molecular characterisation of emerging strains of the virus lies at the heart of current surveillance procedures vital to vaccine preparation and the development of new anti-viral drugs. This research will advance a world-first proteomics surveillance of the virus developed in this laboratory that will enable it to be ch ....Proteomics of the Influenza Virus for In-field Surveillance. The influenza virus continues to pose a serious health risk to Australians and remains a leading cause of death. The molecular characterisation of emerging strains of the virus lies at the heart of current surveillance procedures vital to vaccine preparation and the development of new anti-viral drugs. This research will advance a world-first proteomics surveillance of the virus developed in this laboratory that will enable it to be characterised in-field at the site(s) of infection outbreaks. This rapid response is vital, particularly in the event of a pandemic or a deliberate release of the virus in a bioterrorist attack.Read moreRead less
Endocrine Disrupting Compounds: Novel tests for Analysis and Field Validation. This project will give community benefits from new analytical technology and research data to help minimise the threat of environmental contamination with endocrine-disrupting compounds (EDCs). Both urban and rural communities may feel the impacts of EDCs, with potential contamination occurring globally, affecting both wildlife and humans. The main means of transport of EDCs is as contaminants in water and it is ess ....Endocrine Disrupting Compounds: Novel tests for Analysis and Field Validation. This project will give community benefits from new analytical technology and research data to help minimise the threat of environmental contamination with endocrine-disrupting compounds (EDCs). Both urban and rural communities may feel the impacts of EDCs, with potential contamination occurring globally, affecting both wildlife and humans. The main means of transport of EDCs is as contaminants in water and it is essential to learn the extent of contamination occurring in urban and rural water supplies to decide its significance. The research will involve a multi-disciplinary approach, with benefits falling into all four National Research Priorities of sustainability, good health, frontier analytical technology and national safety.Read moreRead less
Noncanonical epitope recognition by CD8+ T lymphocytes. This proposed research program will provide significant fundamental insight in the areas of immunology and vaccine design. Vaccines for many diseases remain elusive, and this project aims to improve our understanding of the precise regions within pathogens that are the targets for the killer T cells of the immune system. These regions, called epitopes, are likely to be key ingredients in many future vaccines. Although immunologists have gat ....Noncanonical epitope recognition by CD8+ T lymphocytes. This proposed research program will provide significant fundamental insight in the areas of immunology and vaccine design. Vaccines for many diseases remain elusive, and this project aims to improve our understanding of the precise regions within pathogens that are the targets for the killer T cells of the immune system. These regions, called epitopes, are likely to be key ingredients in many future vaccines. Although immunologists have gathered much information about such epitopes, recent studies have shown that some unexpected regions of pathogens are targets for killer T cells. This project will break new ground by utilising unbiased procedures to assess the relative contribution of these noncanonical epitopes to immunity.Read moreRead less