The cellular basis of branching morphogenesis during kidney development. This project aims to study the process of branching morphogenesis which drives the development of the kidney. Previous studies group have demonstrated, in general terms, how branching progresses during gestation. However, little is known about the fundamental cellular events which trigger or characterise this basic developmental process. This project expects to provide deep insights into the cellular basis of tissue and org ....The cellular basis of branching morphogenesis during kidney development. This project aims to study the process of branching morphogenesis which drives the development of the kidney. Previous studies group have demonstrated, in general terms, how branching progresses during gestation. However, little is known about the fundamental cellular events which trigger or characterise this basic developmental process. This project expects to provide deep insights into the cellular basis of tissue and organ development. In studying this process the project should provide critical insights into how cells act, individually and collectively, to build tissues.Read moreRead less
A data science framework for modelling disease patterns from medical images. A data science framework for modelling disease patterns from medical images. This project aims to extract models of disease patterns from medical imaging data, using deep learning, smart image processing, machine learning, and statistical modelling to quantify and model patterns conventional methods cannot detect. These disease models are expected to improve understanding of particular diseases and enable precision medi ....A data science framework for modelling disease patterns from medical images. A data science framework for modelling disease patterns from medical images. This project aims to extract models of disease patterns from medical imaging data, using deep learning, smart image processing, machine learning, and statistical modelling to quantify and model patterns conventional methods cannot detect. These disease models are expected to improve understanding of particular diseases and enable precision medicine, which recognises that there are important differences between individuals with a particular disease, and that when patients are separated into sub-populations with similar disease patterns, treatment can be tailored to these sub-populations.Read moreRead less
Regulation of 3D Cell Migration by Microtubule-Dependent Processes. The overarching aim of this research is to elucidate the molecular mechanisms that cells use to move in 3D environments: a basic biological function essential to development and homeostasis. During these processes, cells interact with their surroundings where they translate biophysical forces into biochemical signals to adapt their shape to move. This requires distinct signalling, controlled in space and time, to regulate the cr ....Regulation of 3D Cell Migration by Microtubule-Dependent Processes. The overarching aim of this research is to elucidate the molecular mechanisms that cells use to move in 3D environments: a basic biological function essential to development and homeostasis. During these processes, cells interact with their surroundings where they translate biophysical forces into biochemical signals to adapt their shape to move. This requires distinct signalling, controlled in space and time, to regulate the crosstalk between organelles and the cytoskeleton. To date, the role of microtubules remains elusive. Using interdisciplinary approaches combining advanced imaging technology with novel cell biology methods, the project aims to uncover fundamental knowledge about how cells interact with their environment.Read moreRead less
Solve it or Ignore it? The Challenge of Alignment Distortion and Creating Next Generation Automatic Facial Expression Detection. The last two decades have seen an escalating interest in automating the coding of facial expressions. Despite this keen interest, the promise of computer vision systems to accurately code facial expressions in natural circumstances remains elusive. Our interdisciplinary team will research a new paradigm to account for facial alignment distortion directly rather than ai ....Solve it or Ignore it? The Challenge of Alignment Distortion and Creating Next Generation Automatic Facial Expression Detection. The last two decades have seen an escalating interest in automating the coding of facial expressions. Despite this keen interest, the promise of computer vision systems to accurately code facial expressions in natural circumstances remains elusive. Our interdisciplinary team will research a new paradigm to account for facial alignment distortion directly rather than aiming to achieve invariance to it. The project will also research new data agnostic feature compaction capabilities to enable scalable learning on the world’s largest and challenging expression dataset available to us through international collaboration. Tackling these two major open problems will make accurate coding of facial expressions in natural environments achievable.Read moreRead less
New Signal Transforms for Multimedia Applications. This project targets at important yet challenging problems for reliable transmission and efficient processing of digital multimedia. The solutions to these problems will not only contribute to our fundamental understanding of digital visual information, but also lead to new commercial opportunities. Hence, the project is clearly within the ARC priority research area 3: Frontier Technologies Frontier Technologies for Building and Transforming Aus ....New Signal Transforms for Multimedia Applications. This project targets at important yet challenging problems for reliable transmission and efficient processing of digital multimedia. The solutions to these problems will not only contribute to our fundamental understanding of digital visual information, but also lead to new commercial opportunities. Hence, the project is clearly within the ARC priority research area 3: Frontier Technologies Frontier Technologies for Building and Transforming Australian Industries. Also, as multimedia market is one of the highest growth segments within the information technology industry, the project is directly in the information and communication technologies (ICT), whose national importance was recognized by the Federal Government. Read moreRead less
Omniscient face recognition for uncooperative subjects. The outcomes of this project will enable effective video surveillance technology to be developed for use by law enforcement and national security agencies. It will lead to reliable identification of humans at a distance by automatically detecting and recognising faces, for use in counter-terrorism surveillance and commercial robot-human interfaces.
Biomedical Visual Image Analytics for Multi-disciplinary Retrieval. The project aims to develop a framework to provide users with the interactive access to information that is necessary for the best collaborative decision-making. Visual analytics theory is becoming increasing valuable for managing ‘big data’ because it can provide interactive and intuitive understanding of the rich information embedded within complex data and decision support systems. There are, however, fundamental challenges t ....Biomedical Visual Image Analytics for Multi-disciplinary Retrieval. The project aims to develop a framework to provide users with the interactive access to information that is necessary for the best collaborative decision-making. Visual analytics theory is becoming increasing valuable for managing ‘big data’ because it can provide interactive and intuitive understanding of the rich information embedded within complex data and decision support systems. There are, however, fundamental challenges that currently prevent visual analytics from being routinely applied to multi-disciplinary collaboration, which is now ‘the norm’ to solve large complicated problems where there is significant social impact. This project aims to address these challenges and improve visual analytics theory by developing a biomedical visual image analytics framework that enables interactive information retrieval of multidisciplinary databases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100055
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
State-of-the-art upgrade to multi-transmit multi-receive technology for research dedicated 3 Tesla magnetic resonance imaging (MRI) scanner. Projects requiring the proposed infrastructure are aligned with two National Research Priorities. The research will lead to new methods for imaging and detecting soft tissue changes, identifying developmental, cognitive and degenerative disorders, and pharmacological research. The understanding of the basis of physiological, cognitive and biochemical proces ....State-of-the-art upgrade to multi-transmit multi-receive technology for research dedicated 3 Tesla magnetic resonance imaging (MRI) scanner. Projects requiring the proposed infrastructure are aligned with two National Research Priorities. The research will lead to new methods for imaging and detecting soft tissue changes, identifying developmental, cognitive and degenerative disorders, and pharmacological research. The understanding of the basis of physiological, cognitive and biochemical processes which will be facilitated by the new equipment will contribute to the priority area Promoting and Maintaining Good Health and will underpin an array of subsequent medical research. The new equipment will extend capabilities and training in signal analysis, biomedical engineering and biomedicine, contributing to the priority area Frontier technologies for Building and Transforming Australian Industries.Read moreRead less
Interactive and scalable media over software defined networks. A novel API and associated algorithms will be developed to exploit the emerging technology of software defined networks (SDN) for improving the efficiency and responsiveness of interactive media browsing applications. The approach applies to conventional streaming video as well as more interactive services based on scalable media compression and communication technology, notably JPIP (IS15444-9) video. Recent advances in motion codin ....Interactive and scalable media over software defined networks. A novel API and associated algorithms will be developed to exploit the emerging technology of software defined networks (SDN) for improving the efficiency and responsiveness of interactive media browsing applications. The approach applies to conventional streaming video as well as more interactive services based on scalable media compression and communication technology, notably JPIP (IS15444-9) video. Recent advances in motion coding will be combined with new spatio-temporal transforms to develop an efficient inter-frame extension to the JPEG 2000 standard that is fully compatible with JPIP. Each of these innovations is important in its own right, but together they will facilitate a highly compelling interactive media browsing experience.Read moreRead less
Massive black holes in the hearts of galaxies. This research will create new insights into the extreme physics of supermassive black holes at the centres of galaxies. Using new instrumentation and analysis techniques to measure the polarisation and variability of their radiation, we will develop models for the infall of gas, the structures surrounding black holes and the merger of massive black holes over cosmic time. The new observing modes that we will develop will provide stepping stones to ....Massive black holes in the hearts of galaxies. This research will create new insights into the extreme physics of supermassive black holes at the centres of galaxies. Using new instrumentation and analysis techniques to measure the polarisation and variability of their radiation, we will develop models for the infall of gas, the structures surrounding black holes and the merger of massive black holes over cosmic time. The new observing modes that we will develop will provide stepping stones toward the Square Kilometre Array, a multi-billion dollar project from which Australia stands to reap enormous scientific and economic benefit. The major advances that we will deliver will boost Australia's already outstanding track record as a world leader in astronomical discovery.
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