Regulation of 3D Cell Migration by Microtubule-Dependent Processes. The overarching aim of this research is to elucidate the molecular mechanisms that cells use to move in 3D environments: a basic biological function essential to development and homeostasis. During these processes, cells interact with their surroundings where they translate biophysical forces into biochemical signals to adapt their shape to move. This requires distinct signalling, controlled in space and time, to regulate the cr ....Regulation of 3D Cell Migration by Microtubule-Dependent Processes. The overarching aim of this research is to elucidate the molecular mechanisms that cells use to move in 3D environments: a basic biological function essential to development and homeostasis. During these processes, cells interact with their surroundings where they translate biophysical forces into biochemical signals to adapt their shape to move. This requires distinct signalling, controlled in space and time, to regulate the crosstalk between organelles and the cytoskeleton. To date, the role of microtubules remains elusive. Using interdisciplinary approaches combining advanced imaging technology with novel cell biology methods, the project aims to uncover fundamental knowledge about how cells interact with their environment.Read moreRead less
Accuracy and cost-effectiveness of technology-assisted dietary assessment. This project aims to compare leading methods for technology-assisted dietary assessment. Excessive cost and questionable accuracy limit the routine use of dietary assessment and undermine decision making in Australia. This project intends to compare three technology methods of assessing diet with the current standard recall method used in population surveys in order to confirm if the use of food images and automated metho ....Accuracy and cost-effectiveness of technology-assisted dietary assessment. This project aims to compare leading methods for technology-assisted dietary assessment. Excessive cost and questionable accuracy limit the routine use of dietary assessment and undermine decision making in Australia. This project intends to compare three technology methods of assessing diet with the current standard recall method used in population surveys in order to confirm if the use of food images and automated methods provide new approaches to improve accuracy and consumer acceptability. Expected outcomes of this project include more accurate and acceptable methods of assessing dietary intake. These findings will inform decision making for researchers, policy makers and practitioners in Australia, and potentially lead to more regular population surveillance.Read moreRead less
Assistive micro-navigation for vision impaired people. This project aims to develop novel algorithms to transform a simple camera into a smart sensor, that can enable a vision-impaired person to navigate freely and without additional aids in a crowded area. Such a smart sensor will be endowed with the capability to detect and locate obstacles, identify the walking path, recognise objects and traffic signs and convey step-by-step instructions to the user. The project outcomes are expected to impr ....Assistive micro-navigation for vision impaired people. This project aims to develop novel algorithms to transform a simple camera into a smart sensor, that can enable a vision-impaired person to navigate freely and without additional aids in a crowded area. Such a smart sensor will be endowed with the capability to detect and locate obstacles, identify the walking path, recognise objects and traffic signs and convey step-by-step instructions to the user. The project outcomes are expected to improve the well-being and accessibility to public areas for vision-impaired people and reduce physical access disparities for this disadvantaged and vulnerable group. Furthermore, technologies developed in this project can potentially be adapted for use in related special navigation applications such as road safety, self-driving vehicles, and autonomous robots.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101297
Funder
Australian Research Council
Funding Amount
$429,000.00
Summary
A novel, dictionary-free, multi-contrast MRI method for microscopic imaging. This project aims to develop a novel quantitative imaging technique for comprehensive in vitro and in vivo tissue characterisation on the microscopic scale. The technology innovated in the project could revolutionise microscopic imaging techniques by breaking through the sub-millimetre image resolution bottleneck of current magnetic resonance imaging (MRI) methods. This project expects to generate new knowledge in the e ....A novel, dictionary-free, multi-contrast MRI method for microscopic imaging. This project aims to develop a novel quantitative imaging technique for comprehensive in vitro and in vivo tissue characterisation on the microscopic scale. The technology innovated in the project could revolutionise microscopic imaging techniques by breaking through the sub-millimetre image resolution bottleneck of current magnetic resonance imaging (MRI) methods. This project expects to generate new knowledge in the emerging field of biological imaging and to deliver an integrated imaging platform for mapping various tissue microscopic components at the cellular level. Successful outcomes have the potential for commercialisation and will accelerate a range of fundamental science and engineering studies requiring imaging techniques.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101402
Funder
Australian Research Council
Funding Amount
$415,000.00
Summary
Multi-scale, multi-modal X-ray imaging using speckle. This project aims to develop new X-ray imaging methods that capture multiple next-generation image modalities at an unprecedented range of length and time scales. While conventional X-ray imaging is routinely used in medicine and industry, it can only visualise high-density materials like bone. To reveal low-density objects like biological soft tissue and microstructure like tiny cracks, the project plans to extract two complementary image mo ....Multi-scale, multi-modal X-ray imaging using speckle. This project aims to develop new X-ray imaging methods that capture multiple next-generation image modalities at an unprecedented range of length and time scales. While conventional X-ray imaging is routinely used in medicine and industry, it can only visualise high-density materials like bone. To reveal low-density objects like biological soft tissue and microstructure like tiny cracks, the project plans to extract two complementary image modalities using a robust setup that does not rely on large-scale facilities. Significant benefits from the developed methods are expected for leading-edge research in fields including biomedicine, materials science and palaeontology, and industries such as security, medical diagnostics and manufacturing.Read moreRead less
Efficient multi-view video coding with cuboids and base anchored models. This project aims to address current deficiencies in multi-view video coding technology to achieve the ultra-compression efficiency demanded by increasing display resolutions and synchronised viewpoints. The project expects to generate new knowledge, by moving from the current pixel-centric approach to methods that concentrate information common to many view-frames. The project is expected to improve compression of audio-vi ....Efficient multi-view video coding with cuboids and base anchored models. This project aims to address current deficiencies in multi-view video coding technology to achieve the ultra-compression efficiency demanded by increasing display resolutions and synchronised viewpoints. The project expects to generate new knowledge, by moving from the current pixel-centric approach to methods that concentrate information common to many view-frames. The project is expected to improve compression of audio-visual services that are of great interest to international standards bodies and industry, while facilitating free interaction and augmented reality. This project will provide significant benefits to broadcast, entertainment, surveillance and health industries and position Australia as a world leader in this field.Read moreRead less
Multi-Modal Dictionary Learning for Smart City Operation and Management. This Project aims to provide new digital asset management tools for city councils to improve city services by utilising new sensing and automated learning technologies for recognising, tracking and auditing of assets. Currently, there are no digital tools available to handle these services. This project proposes new multi-modal sensing and mapping of city asset techniques by building new multi-modal dictionary learning proc ....Multi-Modal Dictionary Learning for Smart City Operation and Management. This Project aims to provide new digital asset management tools for city councils to improve city services by utilising new sensing and automated learning technologies for recognising, tracking and auditing of assets. Currently, there are no digital tools available to handle these services. This project proposes new multi-modal sensing and mapping of city asset techniques by building new multi-modal dictionary learning procedures. The new framework will recognise different conditions of city assets in real-time to make decisions. Expected outcomes of this Project include integration and easy access of assets with unique digital identities to help city councils, governments, and navigation services for real-time asset monitoring.Read moreRead less
Developing key vision technology for automation of aquaculture factory. This project aims to investigate structural, coloured textural, and hyperspectral analysis approaches to achieve automated lobster molt-cycle staging and classification to the level required for commercial production. High labour cost, water contamination, and disease transmission are major barriers in Australian bay lobster aquaculture inhibiting its large scale production. Automation of the production process and reducing ....Developing key vision technology for automation of aquaculture factory. This project aims to investigate structural, coloured textural, and hyperspectral analysis approaches to achieve automated lobster molt-cycle staging and classification to the level required for commercial production. High labour cost, water contamination, and disease transmission are major barriers in Australian bay lobster aquaculture inhibiting its large scale production. Automation of the production process and reducing the human contact with animals are of high priority in the development of this Australian-led emerging industry. The project aims to develop technology to bring this world- first aquaculture factory to large scale production, and create new export opportunities for lobsters and production systems.Read moreRead less
Linking human brain structure to function with ultra-high resolution fMRI. This project will examine the structure and function of the sensory cortex of the human brain using ultra-high resolution functional magnetic resonance imaging (7 Tesla MRI). The project pushes new boundaries for resolution with ultra-high field MRI (7 Tesla) and, as such, will advance techniques for the acquisition, analysis, and computational modelling of high-resolution fMRI brain imaging, providing detail of the funct ....Linking human brain structure to function with ultra-high resolution fMRI. This project will examine the structure and function of the sensory cortex of the human brain using ultra-high resolution functional magnetic resonance imaging (7 Tesla MRI). The project pushes new boundaries for resolution with ultra-high field MRI (7 Tesla) and, as such, will advance techniques for the acquisition, analysis, and computational modelling of high-resolution fMRI brain imaging, providing detail of the functional organisation of the sensory cortex at a level never previously possible in the living human brain. This will provide new understanding of the neural-level networks that underpin attention and touch perception in the human brain.Read moreRead less
The worlds next door: terrestrial exoplanets with the TOLIMAN space mission. This project aims to to explore our nearest neighbour star system, Alpha Centauri, for the first time probing for exoplanets with physical characteristics that resemble those of Earth. The finding of any such world, with the potential to support a biosphere like our own and lying only 4 light-years away, would profoundly alter our view of our place in the universe. The primary outcome of this project will be the design, ....The worlds next door: terrestrial exoplanets with the TOLIMAN space mission. This project aims to to explore our nearest neighbour star system, Alpha Centauri, for the first time probing for exoplanets with physical characteristics that resemble those of Earth. The finding of any such world, with the potential to support a biosphere like our own and lying only 4 light-years away, would profoundly alter our view of our place in the universe. The primary outcome of this project will be the design, construction, launch and operation of a novel and innovative space telescope: the TOLIMAN mission. This profoundly benefits the Australian space and university sectors, partnering them with international agencies to deliver marquee science with global impact: the search for our first stepping stone to interstellar space.Read moreRead less