Regulation of 3D Cell Migration by Microtubule-Dependent Processes. The overarching aim of this research is to elucidate the molecular mechanisms that cells use to move in 3D environments: a basic biological function essential to development and homeostasis. During these processes, cells interact with their surroundings where they translate biophysical forces into biochemical signals to adapt their shape to move. This requires distinct signalling, controlled in space and time, to regulate the cr ....Regulation of 3D Cell Migration by Microtubule-Dependent Processes. The overarching aim of this research is to elucidate the molecular mechanisms that cells use to move in 3D environments: a basic biological function essential to development and homeostasis. During these processes, cells interact with their surroundings where they translate biophysical forces into biochemical signals to adapt their shape to move. This requires distinct signalling, controlled in space and time, to regulate the crosstalk between organelles and the cytoskeleton. To date, the role of microtubules remains elusive. Using interdisciplinary approaches combining advanced imaging technology with novel cell biology methods, the project aims to uncover fundamental knowledge about how cells interact with their environment.Read moreRead less
Solve it or Ignore it? The Challenge of Alignment Distortion and Creating Next Generation Automatic Facial Expression Detection. The last two decades have seen an escalating interest in automating the coding of facial expressions. Despite this keen interest, the promise of computer vision systems to accurately code facial expressions in natural circumstances remains elusive. Our interdisciplinary team will research a new paradigm to account for facial alignment distortion directly rather than ai ....Solve it or Ignore it? The Challenge of Alignment Distortion and Creating Next Generation Automatic Facial Expression Detection. The last two decades have seen an escalating interest in automating the coding of facial expressions. Despite this keen interest, the promise of computer vision systems to accurately code facial expressions in natural circumstances remains elusive. Our interdisciplinary team will research a new paradigm to account for facial alignment distortion directly rather than aiming to achieve invariance to it. The project will also research new data agnostic feature compaction capabilities to enable scalable learning on the world’s largest and challenging expression dataset available to us through international collaboration. Tackling these two major open problems will make accurate coding of facial expressions in natural environments achievable.Read moreRead less
Omniscient face recognition for uncooperative subjects. The outcomes of this project will enable effective video surveillance technology to be developed for use by law enforcement and national security agencies. It will lead to reliable identification of humans at a distance by automatically detecting and recognising faces, for use in counter-terrorism surveillance and commercial robot-human interfaces.
System to synapse. Biological tissue is studied at the cellular and organ level with ever increasing clarity and sensitivity, but there are limitations in understanding how microscopic changes are manifested in the organ and vice versa. This project will develop new methods to bridge this gap and allow next generation correlative imaging.
Automatic cartilage segmentation in magnetic resonance imaging. Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 1.4 million Australians. This research aims at engineering new tools for use in Magnetic Resonance Imaging systems to enable automated analyses of the cartilage and bones in joint images. The goals of the work are to assist with improved diagnosis and treatment planning for both chronic disease, such as OA, and acute injuries, such as cartilage and ligament ....Automatic cartilage segmentation in magnetic resonance imaging. Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 1.4 million Australians. This research aims at engineering new tools for use in Magnetic Resonance Imaging systems to enable automated analyses of the cartilage and bones in joint images. The goals of the work are to assist with improved diagnosis and treatment planning for both chronic disease, such as OA, and acute injuries, such as cartilage and ligament tears in sporting injuries and other traumas.
The software developed will be provided on the project’s partner (Siemens) platform and will therefore be available worldwide and have a consequently large impact on the field.
Read moreRead less
Machine Assisted, Multi-scale Spatial and Temporal Observation and Modeling of Marine Benthic Habitats. The Integrated Marine Observing System (IMOS) science plans include sampling campaigns reliant on Autonomous Underwater Vehicle (AUV) Facility data and designed to address the issues of marine biodiversity quantification and assurance. The proposed research will directly enhance the effectiveness of these programs by speeding labour-intensive analyses, aggregating the results, and searching f ....Machine Assisted, Multi-scale Spatial and Temporal Observation and Modeling of Marine Benthic Habitats. The Integrated Marine Observing System (IMOS) science plans include sampling campaigns reliant on Autonomous Underwater Vehicle (AUV) Facility data and designed to address the issues of marine biodiversity quantification and assurance. The proposed research will directly enhance the effectiveness of these programs by speeding labour-intensive analyses, aggregating the results, and searching for ecological patterns on a national scale that would be difficult to identify using traditional approaches tuned to process-scale studies. Australian society stands to benefit by virtue of improved large-scale models of ecosystem function and reduced cost for conducting marine ecosystem investigations.Read moreRead less
High resolution single particle analysis of biological macromolecules. One of the great challenges of cell biology is to increase the rate of atomic resolution structure determination, particularly of membrane proteins and macromolecular assemblies. The current rate-limiting step is high quality crystal production. Our goal is to prove that protein structures can be determined to atomic resolution by single-particle analysis. 3D structures will be produced by computationally aligning high-resolu ....High resolution single particle analysis of biological macromolecules. One of the great challenges of cell biology is to increase the rate of atomic resolution structure determination, particularly of membrane proteins and macromolecular assemblies. The current rate-limiting step is high quality crystal production. Our goal is to prove that protein structures can be determined to atomic resolution by single-particle analysis. 3D structures will be produced by computationally aligning high-resolution electron microscope images of individual, randomly oriented molecules. The importance of this project is highlighted by the fact over 120,000 protein sequences are already databased, a number set to increase rapidly as new genome sequencing projects are completed.
Read moreRead less
International Evaluation of Algorithms for Mapping in Optically Shallow Waters. This work provides a means for Australian science and management agencies to apply a method for accurately mapping shallow coastal environments. The work will build Australian research capability by developing new collaborations among experienced researchers; as well as allowing the Australian teams to benchmark their proposed methods internationally. Nationally, the work will strengthen international research exper ....International Evaluation of Algorithms for Mapping in Optically Shallow Waters. This work provides a means for Australian science and management agencies to apply a method for accurately mapping shallow coastal environments. The work will build Australian research capability by developing new collaborations among experienced researchers; as well as allowing the Australian teams to benchmark their proposed methods internationally. Nationally, the work will strengthen international research experience and generate opportunities for postgraduate and postdoctoral researchers to link into leading-edge international research networks. This work will also allow us to build strong ongoing collaborations between research teams in Australia and their counterparts overseas (specifically USA, Canada, UK and Germany). Read moreRead less
Special Research Initiatives - Grant ID: SR0354734
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving h ....The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving health care and reducing health care costs. To be successful, a device must include all relevant disciplines in the research, development and testing phases. This network will bring together these groups, promoting knowledge sharing and cross-disciplinary investigations that illuminate current device limitations and potential solutions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101297
Funder
Australian Research Council
Funding Amount
$429,000.00
Summary
A novel, dictionary-free, multi-contrast MRI method for microscopic imaging. This project aims to develop a novel quantitative imaging technique for comprehensive in vitro and in vivo tissue characterisation on the microscopic scale. The technology innovated in the project could revolutionise microscopic imaging techniques by breaking through the sub-millimetre image resolution bottleneck of current magnetic resonance imaging (MRI) methods. This project expects to generate new knowledge in the e ....A novel, dictionary-free, multi-contrast MRI method for microscopic imaging. This project aims to develop a novel quantitative imaging technique for comprehensive in vitro and in vivo tissue characterisation on the microscopic scale. The technology innovated in the project could revolutionise microscopic imaging techniques by breaking through the sub-millimetre image resolution bottleneck of current magnetic resonance imaging (MRI) methods. This project expects to generate new knowledge in the emerging field of biological imaging and to deliver an integrated imaging platform for mapping various tissue microscopic components at the cellular level. Successful outcomes have the potential for commercialisation and will accelerate a range of fundamental science and engineering studies requiring imaging techniques.Read moreRead less