Evolution on the edge: a model system for evolution on invasion fronts. This project aims to develop a shared experimental platform, using the well-studied ecological model, Daphnia, to test emergent predictions about evolution on invasion fronts. Evolution happens rapidly on invasion fronts, accelerating the speed and potentially the damage caused by an invasion. By manipulating invasions through an experimental landscape, the project aims to answer currently infeasible questions, including whe ....Evolution on the edge: a model system for evolution on invasion fronts. This project aims to develop a shared experimental platform, using the well-studied ecological model, Daphnia, to test emergent predictions about evolution on invasion fronts. Evolution happens rapidly on invasion fronts, accelerating the speed and potentially the damage caused by an invasion. By manipulating invasions through an experimental landscape, the project aims to answer currently infeasible questions, including whether pathogens become more virulent as they spread, and whether evolutionary trade-offs place limits on spread rate. This work would dramatically improve our understanding of biological invasions and may have implications for the management of phenomena ranging from emergent diseases to invasive pests and malignant growths.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100470
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Understanding mechanisms and functions of evolutionary divergence in innate immune genes. Microorganisms constantly challenge the immune systems of all multi-cellular organisms, and host immune genes must be able to co-evolve with microbes in order for a species to propagate. This project will investigate how host immune genes in a species evolve to enable that species to continue.
Threats of avian pathogens to endangered parrots and human health: developing and utilizing tools for risk reduction. Emerging infectious diseases (EID) are among the most significant threats to conservation, agriculture and public health worldwide. Among these are two globally significant avian pathogens, Chlamydia psittaci and Beak and Feather Disease Virus. This project aims to determine transmission dynamics, fitness costs of infection, and quantify the roles of genetic diversity and host st ....Threats of avian pathogens to endangered parrots and human health: developing and utilizing tools for risk reduction. Emerging infectious diseases (EID) are among the most significant threats to conservation, agriculture and public health worldwide. Among these are two globally significant avian pathogens, Chlamydia psittaci and Beak and Feather Disease Virus. This project aims to determine transmission dynamics, fitness costs of infection, and quantify the roles of genetic diversity and host stress in infection and disease emergence. The project aims to also determine to what extent zoonotic poultry/human infection is related to infection in wild birds. The outcomes aim to be the development of critical knowledge and tools to help manage two avian pathogens causing significant conservation, agricultural and public health concern around the world.Read moreRead less
Mechanisms of virulence of amphibian chytridiomycosis and factors influencing their evolution. Chytridiomycosis is a fatal fungal disease causing amphibian population declines as it spreads globally. By analysing the genes, proteins and metabolites of the fungus, we will determine how infection leads to death. This will enable surveys for virulent fungal strains and potential enhancement of host resistance.
Nucleomodulin effectors of the environmental pathogen Legionella. This project aims to examine the evolution of Legionella as an intracellular organism and the mechanisms by which the bacteria evade environmental predation by amoebae. Aside from the advancement of knowledge, expected outcomes of this project include a greater understanding of amoebae. This will provide significant benefits, and this knowledge may be used to develop inhibitors of amoebae growth.
A lipodomic approach to cnidarian-dinoflagellate symbiosis. Fatty Acids are essential for human health and for reef health. This lipodomic study using newly developed techniques, aims to understand the essential and non-essential fatty acid metabolic exchange in the symbiosis that drives coral reef formation and health, and in turn gives reflective insight into our own metabolism.
Safeguarding honeybees: understanding host-parasite interactions at the level of proteins. Parasites are responsible for dramatic declines of honeybee populations resulting in a loss of pollination services and posing a threat to food production and ecosystem stability. This project will study the honeybee immune system and its interactions with bee parasites on the molecular scale, which will be important to guide future bee breeding.
Integrating nutritional immunology. What an organism eats affects both its susceptibility to disease and the community of beneficial microorganisms living within its gut. This project will study how nutrition, immunity and the flora of the gut interact, and whether hosts are able to select a diet that optimises their immune response and gut flora in the face of disease challenges.
An interdisciplinary approach to host-pathogen interactions in infection. This project aims to understand the molecular and cellular interactions between host and parasite, as well as providing a quantitative framework for analysing infection dynamics in other systems. Infection involves a complex interaction between the host and the parasite, which is very dynamic and therefore difficult to study by traditional sampling and analysis approaches. This project has combined mathematical modelling w ....An interdisciplinary approach to host-pathogen interactions in infection. This project aims to understand the molecular and cellular interactions between host and parasite, as well as providing a quantitative framework for analysing infection dynamics in other systems. Infection involves a complex interaction between the host and the parasite, which is very dynamic and therefore difficult to study by traditional sampling and analysis approaches. This project has combined mathematical modelling with a novel experimental protocol to allow the study of kinetics of parasite replication in vivo. Expected outcomes will provide significant benefits, such as new avenues for vaccination and immune intervention.Read moreRead less
The role of auxin in root organ specification - from symbiont to parasite. Sustainable agriculture in a changing climate depends on strategies to maximise crop performance and to minimise crop losses due to parasites. This project aims to identify genes and molecular mechanisms that symbiotic and parasitic microbes, which affect major crop plants, use to alter plant growth in a beneficial or detrimental way.