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An anti-senescence nanoplatform and its underlying mechanism. The project will bring together complementary expertise and skills by combining biomaterials, cell and molecular biology, and engineering, to develop a novel nano-biomaterial platform for anti-senescence and gain an in-depth understanding of its underlying mechanisms. The underlying mechanisms of senescence remain elusive and bone substitutes with anti-senescence property have not been explored and becoming a growing field of interest ....An anti-senescence nanoplatform and its underlying mechanism. The project will bring together complementary expertise and skills by combining biomaterials, cell and molecular biology, and engineering, to develop a novel nano-biomaterial platform for anti-senescence and gain an in-depth understanding of its underlying mechanisms. The underlying mechanisms of senescence remain elusive and bone substitutes with anti-senescence property have not been explored and becoming a growing field of interest in bone regeneration. The project will develop a well-defined and efficient nanomaterial platform with optimal combination of nano-surface features and chemistry for cell rejuvenation, and it will give unprecedented depth of interdisciplinary understanding of senescence rejuvenation mechanisms.Read moreRead less
Day-to-day life of adults after age 85: the interplay of mood, engagement, cognition and health in the context of prior functioning. The research will offer considerable social benefits to the Australian community by providing a rare insight into how people over the age of 85 can continue to contribute actively to, and remain engaged with, society. It will improve knowledge and understanding of productive ageing by examining how everyday cognition and mood vary depending on different situational ....Day-to-day life of adults after age 85: the interplay of mood, engagement, cognition and health in the context of prior functioning. The research will offer considerable social benefits to the Australian community by providing a rare insight into how people over the age of 85 can continue to contribute actively to, and remain engaged with, society. It will improve knowledge and understanding of productive ageing by examining how everyday cognition and mood vary depending on different situational contexts and daily activities. It will offer information on the challenges and opportunities experienced by this group of older adults, and reveal the inter-relatedness of social networks, isolation, independence and health for this group of very old adults.Read moreRead less
Resilient ageing and the oldest-old in the Australian longitudinal study of ageing. This project will provide a better understanding of resiliency (positive adaptation) in oldest-old Australians (85 plus). At a time in history when the population is ageing at an unprecedented rate, understanding how the oldest-old respond adaptively to age-related challenges is critically important to informing ageing policies and service provision.