Sociogenomics of honeybees. From genes to society. This project will show how complex social behaviour of honeybees like dance communication and thermoregulation is genetically controlled. The complete sequence of the honeybee genome will be published in 2003, and a gene chip based on it will be created shortly afterwards. These new technologies will make our project technically feasible. By backcrossing, workers with different genetic tendencies to do a task can be generated within an otherwi ....Sociogenomics of honeybees. From genes to society. This project will show how complex social behaviour of honeybees like dance communication and thermoregulation is genetically controlled. The complete sequence of the honeybee genome will be published in 2003, and a gene chip based on it will be created shortly afterwards. These new technologies will make our project technically feasible. By backcrossing, workers with different genetic tendencies to do a task can be generated within an otherwise uniform background. Age-matched workers that perform a behaviour like thermoregulation can be compared to sisters that do not, and the genes that are switched on in the two groups compared.Read moreRead less
Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. Inte ....Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. International attention has already resulted in genome characterization of Australian icons (wallaby, Tasmanian devil and platypus), more research on these, and other Australian animals, will further highlight the importance of Australian fauna and impact positively on our scientific profile.Read moreRead less
Regulation of Plant Development by Small RNAs. Understanding the roles of small RNAs and their pathways is a new field of research that is giving, and will continue to give profound insights into how multicellular organisms regulate gene expression at a genomic level. Research in this area has already led to RNA interference technology, by which almost any gene can be switched off, and there is considerable potential for other gene silencing and trait modification technologies to emerge. The pro ....Regulation of Plant Development by Small RNAs. Understanding the roles of small RNAs and their pathways is a new field of research that is giving, and will continue to give profound insights into how multicellular organisms regulate gene expression at a genomic level. Research in this area has already led to RNA interference technology, by which almost any gene can be switched off, and there is considerable potential for other gene silencing and trait modification technologies to emerge. The project will yield insights into fundamental biological processes which are expected to engender applications in agriculture and biotechnology. It will maintain and enhance Australia's position in this area.Read moreRead less
Microbial genomics of the southern ocean: monitoring environmental health. This program will derive an integrated understanding of microbial ecology which is essential for determining ways of preserving the health of the World's ecosystems. Through the development of a unique microbial genomics program, Australia will remain a world leader in Antarctic biology, strengthening Australia's reputation in technologically innovative scientific programs of global significance, training local scientists ....Microbial genomics of the southern ocean: monitoring environmental health. This program will derive an integrated understanding of microbial ecology which is essential for determining ways of preserving the health of the World's ecosystems. Through the development of a unique microbial genomics program, Australia will remain a world leader in Antarctic biology, strengthening Australia's reputation in technologically innovative scientific programs of global significance, training local scientists in cutting edge genomic biology and fostering the interests of the international community in sciences ranging from microbial ecology to climate change.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560987
Funder
Australian Research Council
Funding Amount
$156,697.00
Summary
Robust High Resolution Gene and Protein Expression Analysis Facilities in WA. Biological research is playing an increasingly important role in keeping agriculture internationally competitive and helping to unravel the basic mechanisms underpinning plant and animal health. This collaborative research equipment will greatly enhance and extend our existing functional genomic facilities in WA, allowing robust pre-fractionation of samples for directed proteomic analysis within complex systems and al ....Robust High Resolution Gene and Protein Expression Analysis Facilities in WA. Biological research is playing an increasingly important role in keeping agriculture internationally competitive and helping to unravel the basic mechanisms underpinning plant and animal health. This collaborative research equipment will greatly enhance and extend our existing functional genomic facilities in WA, allowing robust pre-fractionation of samples for directed proteomic analysis within complex systems and allowing accurate and sensitive measurement of gene expression. Both of these are critical for analysis of low abundance components involved in signalling and regulatory functions in biological samples.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668440
Funder
Australian Research Council
Funding Amount
$850,000.00
Summary
Advanced technology for transcriptomics, genomics and gene mapping. Acquistion of the equipment requested in this application will maintain the expertise developed by researchers within New South Wales and attract and retain exceptional individuals who can contribute to our understanding of how genes interact with one another. The benefit of such an enhances facility will be the delivery of a better functional understanding of health and disease which will provide both community and national be ....Advanced technology for transcriptomics, genomics and gene mapping. Acquistion of the equipment requested in this application will maintain the expertise developed by researchers within New South Wales and attract and retain exceptional individuals who can contribute to our understanding of how genes interact with one another. The benefit of such an enhances facility will be the delivery of a better functional understanding of health and disease which will provide both community and national benefits. The primary purpose of this LIEF application is to standardize approaches to the study of genome function across the nodes of the Ramaciotti facility and to expand the capacities of the facility to cope with the increased demand in this technology. Read moreRead less
Bayesian methodology for analysis of genome data with focus on the livestock industry. The aim is to develop statistical methods for the design and analysis of genome data with focus on the special needs of the livestock industry. This will significantly contribute to profitability, quality, genetic improvement and genetic knowledge in a key national industry, improve Australia's international and national profile in the key research area of bioinformatics, and encourage optimisation of current ....Bayesian methodology for analysis of genome data with focus on the livestock industry. The aim is to develop statistical methods for the design and analysis of genome data with focus on the special needs of the livestock industry. This will significantly contribute to profitability, quality, genetic improvement and genetic knowledge in a key national industry, improve Australia's international and national profile in the key research area of bioinformatics, and encourage optimisation of current information. Outcomes include a toolkit of applicable statistical methods, statistically valid algorithms, marketable methods for gene discovery, technology transfer, training and publications.Read moreRead less
The molecular basis of cold adaptation: an integrated genomic and proteomic study of Antarctic archaea. The project enables Australia to remain a world leader in extremophiles, cold adaptation and Antarctic biology, strengthening the reputation Australian scientists have in scientific programs of global significance and fostering the interests of the international community in sciences ranging from bioprospecting to the search for extraterrestrial life. National benefit is directly derived from ....The molecular basis of cold adaptation: an integrated genomic and proteomic study of Antarctic archaea. The project enables Australia to remain a world leader in extremophiles, cold adaptation and Antarctic biology, strengthening the reputation Australian scientists have in scientific programs of global significance and fostering the interests of the international community in sciences ranging from bioprospecting to the search for extraterrestrial life. National benefit is directly derived from technological innovation and training local scientists in modern biology of environmental microorganisms. The Antarctic microorganisms provide unique compounds, enzymes and molecules for biotechnology and industry. Insight will be gained into the critical role that methanogens play in the global carbon cycle and global warming.Read moreRead less
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668507
Funder
Australian Research Council
Funding Amount
$260,000.00
Summary
Real time PCR and nanoparticle diagnostic facilities for high-throughput quantitative analysis of genomic structure and gene expression. Modern molecular tools have lead to an explosion in genome projects and unification of all areas of biology. The most basic need for such research is access to improving technologies for detecting DNA fingerprints that distinguish genetically-diverse genes, and determining which genes are "switched on" or 'off' in various situations. Real time PCR technology, ....Real time PCR and nanoparticle diagnostic facilities for high-throughput quantitative analysis of genomic structure and gene expression. Modern molecular tools have lead to an explosion in genome projects and unification of all areas of biology. The most basic need for such research is access to improving technologies for detecting DNA fingerprints that distinguish genetically-diverse genes, and determining which genes are "switched on" or 'off' in various situations. Real time PCR technology, pioneered by The University of Queensland (UQ) and Southern Cross University (SCU) using ARC funding in 1996, is now the technology of choice for much of this research. This project will provide high-throughput equipment for real time PCR, and will develop complementary high-throughput "nanoparticle" DNA genotyping technologies, with applications to medicine and agriculture.
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