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Iron, ferroptosis and the biology of ageing. This project aims to determine how and when regulation of iron is lost. Failing iron metabolism during life may dictate the rate of ageing by driving a newly discovered cell death program. Combining biology, chemistry and physics, this collaborative project aims to transform the understanding of the fundamental mechanisms of biological ageing. Anticipated outcomes include new assays for measuring iron in biology and identification of potential pathway ....Iron, ferroptosis and the biology of ageing. This project aims to determine how and when regulation of iron is lost. Failing iron metabolism during life may dictate the rate of ageing by driving a newly discovered cell death program. Combining biology, chemistry and physics, this collaborative project aims to transform the understanding of the fundamental mechanisms of biological ageing. Anticipated outcomes include new assays for measuring iron in biology and identification of potential pathways that regulate death signaling and lifespan. Outcomes will benefit life sciences and biotechnology industries.Read moreRead less
A behaviour-genetic study of the National Assessment Program - Literacy and Numeracy (NAPLAN) results. The National Assessment Program - Literacy and Numeracy (NAPLAN) tests are designed by educational authorities, are objective, and have been administered Australia-wide since 2008 so are unquestionably the most valuable national database on school achievement available. This project's twin studies of this data will provide a more solid base for public policy debates on educational policy and pr ....A behaviour-genetic study of the National Assessment Program - Literacy and Numeracy (NAPLAN) results. The National Assessment Program - Literacy and Numeracy (NAPLAN) tests are designed by educational authorities, are objective, and have been administered Australia-wide since 2008 so are unquestionably the most valuable national database on school achievement available. This project's twin studies of this data will provide a more solid base for public policy debates on educational policy and practice.Read moreRead less
Inter-kingdom signalling in animal health and disease. This project aims to understand how animals can control their bacterial associates. Animals evolved in a world dominated by bacteria, and intimately associated microbes affect the development, health and disease of all animals – from corals to man. To date, animal-microbe interactions have been studied nearly exclusively in terms of how bacteria affect animals. the researchers have discovered that the coral Acropora can control its associate ....Inter-kingdom signalling in animal health and disease. This project aims to understand how animals can control their bacterial associates. Animals evolved in a world dominated by bacteria, and intimately associated microbes affect the development, health and disease of all animals – from corals to man. To date, animal-microbe interactions have been studied nearly exclusively in terms of how bacteria affect animals. the researchers have discovered that the coral Acropora can control its associated bacteria. Understanding how a simple animal manipulates its microbial associates should have implications for coral disease and resilience and for health and disease across the animal kingdom.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100894
Funder
Australian Research Council
Funding Amount
$361,140.00
Summary
Nanolamps: unlocking targeted gene silencing in deep tissue with nanoparticle-based light sources. In order to better understand the function of genes, this project will develop a new method of tightly targeted gene silencing deep inside of the body by nanoscale light sources. This will shed new light on the nervous system and, in the first instance, help to elucidate the role of the PACAP neurons in blood pressure regulation.
Investigating novel pathways in ferroptosis. This project aims to develop new tools to investigate iron-mediated cell death and uncover new pathways involved in ageing. Accumulation of iron leads to frailty in late life, a process that appears common to all animals. Iron becomes reactive and inappropriately triggers a cell death process called ferroptosis leading to dysfunction. To understand these processes and to identify means to intervene, this project aims to use genetic approaches to ident ....Investigating novel pathways in ferroptosis. This project aims to develop new tools to investigate iron-mediated cell death and uncover new pathways involved in ageing. Accumulation of iron leads to frailty in late life, a process that appears common to all animals. Iron becomes reactive and inappropriately triggers a cell death process called ferroptosis leading to dysfunction. To understand these processes and to identify means to intervene, this project aims to use genetic approaches to identify new cell pathways that regulate ferroptosis. This project also aims to develop new tools to study this process. Outcomes of this project may include the identification of potential strategies to alter late life frailty with an expected benefit to life sciences and biotechnology industries.Read moreRead less
Arterial stiffness: mechanistic role of interaction of cellular processes and the extracellular matrix. Arterial stiffness causes high blood pressure with age, so with more people living longer it is important to understand why arteries become stiff. This investigation uses genetically engineered mice to study how changes in nitric oxide in the cells of the artery wall can lead to changes in the wall material and so affect arterial stiffness.
Testing links between life-history and genome evolution. Chromosomes are fundamental units of inheritance. They often differ in number, size and structure between species, and may also differ between individuals within a species. The evolution of chromosomes is tied to that of organisms themselves, making them important for understanding the generation and maintenance of biodiversity. Yet, our understanding of the forces that influence chromosome evolution remains limited. This project will inve ....Testing links between life-history and genome evolution. Chromosomes are fundamental units of inheritance. They often differ in number, size and structure between species, and may also differ between individuals within a species. The evolution of chromosomes is tied to that of organisms themselves, making them important for understanding the generation and maintenance of biodiversity. Yet, our understanding of the forces that influence chromosome evolution remains limited. This project will investigate the formation of unusual chains of chromosomes that are increasingly being found in various vertebrate and invertebrate taxa, using an organism in which they are most commonly found: termites. We will test the hypothesis that inbreeding drives the evolution of meiotic sex linked chromosomes.Read moreRead less
Comparative toxicology of a fumigant and gasotransmitters: Testing a new model of fumigant toxicity in Caenorhabditis elegans. Fumigants share physical, chemical and functional properties with a medically important class of signalling molecules called gasotransmitters. This project proposes that the toxicity of fumigants is directly caused by their ability to mimic and disrupt gasotransmitter signalling. This project will test this hypothesis using the fumigant phosphine, a chemical that protect ....Comparative toxicology of a fumigant and gasotransmitters: Testing a new model of fumigant toxicity in Caenorhabditis elegans. Fumigants share physical, chemical and functional properties with a medically important class of signalling molecules called gasotransmitters. This project proposes that the toxicity of fumigants is directly caused by their ability to mimic and disrupt gasotransmitter signalling. This project will test this hypothesis using the fumigant phosphine, a chemical that protects the vast majority of the world grain supply from insect pests. This work will show us what makes a fumigant toxic. This knowledge will facilitate the discovery and effective deployment of new fumigants.Read moreRead less
Lamarckian lizards: novel integration of telomere epigenetics, free radicals and innate antioxidants in condition-dependant sexual signal evolution. In 2009, the Nobel Prize in physiology was awarded Drs. Blackburn, Greider and Szostak for discoveries on telomeres. This project will investigate how telomeres not only cap chromosomes from destruction by free radicals, but also have a key role in life itself, in their influence on ageing, longevity, ornaments and lifetime reproductive success.
Discovery Early Career Researcher Award - Grant ID: DE140100217
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Harnessing Mendel’s workhorse: meiotic crossovers for genetic diversity in crop breeding. Introducing genetic diversity from wild species into elite lines of wheat and barley may increase their resistance to the stresses they are exposed to in the field. Modern breeding cultivars could capture up to ten times more genetic variation. This project aims to gain fundamental insights into the genetic and environmental factors that limit the rates at which new genomic combinations can be made. This wi ....Harnessing Mendel’s workhorse: meiotic crossovers for genetic diversity in crop breeding. Introducing genetic diversity from wild species into elite lines of wheat and barley may increase their resistance to the stresses they are exposed to in the field. Modern breeding cultivars could capture up to ten times more genetic variation. This project aims to gain fundamental insights into the genetic and environmental factors that limit the rates at which new genomic combinations can be made. This will transform wheat and barley breeding methods, unlocking available genetic diversity to produce new varieties. Read moreRead less