I am a clinician-scientist and endocrinologist most interested in clinical problems associated with bone, in particular the highly heritable disease of osteoporosis. I hope by studying genetic determinants of bone mass to determine the key genes involved, with the long term aim of informing the development of novel therapies for this common, painful and disabling disease.
Statistical Methods For Identifying Genes Involved In Common Complex Disease
Funder
National Health and Medical Research Council
Funding Amount
$307,232.00
Summary
Better understanding of the genetic component of common diseases (e.g. melanoma, psychiatric disorders) is likely to lead to improved public health. Identification of disease susceptibility loci is currently one of the primary means for increasing our understanding of the biochemical and developmental pathways involved in many common diseases. This application will focus on developing new statistical genetic methods to better understand genetic variation and to allow more effective gene mapping.
Generation Of Mouse Models To Study The Roles Of Different Bcl-2 Family Members In The Regulation Of Apaptosis
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
Programmed cell death, or apoptosis, is required for the removal of infected, damaged or unwanted cells and its disrupted regulation is implicated in cancer, autoimmunity and degenerative disorders. The Bcl-2 family of proteins are key regulators of apoptosis. We propose to generate several mouse models to better understand the relationships between the different members of the Bcl-2 family in an effort to control this pathway for therapeutic purposes.