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New uses for milk-derived products for eradication of Helicobacter pylori infection and gastro-intestinal site-specific delivery of active agents. Helicobacter pylori is the most significant bacterial pathogen in the world, infecting 50% globally. Current treatments are inducing rapid antibiotic resistance and are thus becoming increasingly less effective. The infection is acquired in childhood and new methods to prevent and/or treat the infection, minimising acquisition of antibiotic resistance ....New uses for milk-derived products for eradication of Helicobacter pylori infection and gastro-intestinal site-specific delivery of active agents. Helicobacter pylori is the most significant bacterial pathogen in the world, infecting 50% globally. Current treatments are inducing rapid antibiotic resistance and are thus becoming increasingly less effective. The infection is acquired in childhood and new methods to prevent and/or treat the infection, minimising acquisition of antibiotic resistance are urgently required. This project seeks to develop new ways of doing this that combine novel antibacterials with techniques to deliver them (and monitor this delivery) as well as modify the complex protective habitat in the stomach.Read moreRead less
Gastrointestinal parasites and their diagnosis. Gastrointestinal disease such as diarrhoea, abdominal pain and irritable bowel syndrome are common in the Australian population and there are a wide variety of causes, including potentially parasites. The parasite Dientamoeba fragilis has, until recently, been overlooked as a cause of human disease, but recent studies have confirmed its role as a pathogen. This project seeks to improve the diagnosis of this organism in faeces and this development ....Gastrointestinal parasites and their diagnosis. Gastrointestinal disease such as diarrhoea, abdominal pain and irritable bowel syndrome are common in the Australian population and there are a wide variety of causes, including potentially parasites. The parasite Dientamoeba fragilis has, until recently, been overlooked as a cause of human disease, but recent studies have confirmed its role as a pathogen. This project seeks to improve the diagnosis of this organism in faeces and this development will allow effective treatment to be used in patients thereby ameliorating disease.Read moreRead less