Fighting disease on farms: how do vaccinations drive evolution of new pathogen strains? Vaccinating against some types of infectious diseases can drive evolution of new variants of the pathogen. This project will show how bacterial populations evolve in response to vaccination in farms, leading to new vaccination strategies and improved vaccine formulations to better control diseases that are caused by highly variable bacteria.
Understanding fish-killing mechanisms by harmful algal blooms: towards the design of effective mitigation strategies. Fish-killing microalgal blooms cause multi-million dollar losses to global aquaculture and wild fisheries. This project brings together leading Australian and Canadian research teams, applying sophisticated cell line and biologically active molecule technologies, to elucidate precise fish-kill mechanisms and design effective mitigation strategies.
Industrial Transformation Research Hubs - Grant ID: IH210100014
Funder
Australian Research Council
Funding Amount
$4,996,503.00
Summary
ARC Research Hub for Supercharging Tropical Aquaculture Through Genetic Solutions. This project will deliver the genetic knowledge to instigate world-leading and highly productive breeding programs for five tropical aquaculture species (barramundi, pearl oyster, prawn, grouper and marine algae) in northern Australia. It will integrate cutting edge genetic and genomic approaches into innovative aquaculture enterprises and will establish a novel understanding of the genetic basis of disease resist ....ARC Research Hub for Supercharging Tropical Aquaculture Through Genetic Solutions. This project will deliver the genetic knowledge to instigate world-leading and highly productive breeding programs for five tropical aquaculture species (barramundi, pearl oyster, prawn, grouper and marine algae) in northern Australia. It will integrate cutting edge genetic and genomic approaches into innovative aquaculture enterprises and will establish a novel understanding of the genetic basis of disease resistance and how the production environment interfaces with the bacterial microbiome, pathogens and water quality to cause disease. Outcomes will lead to increased productivity, international competitiveness, and lowered disease risk and significantly expand Australia's capacity in the aquaculture sector.Read moreRead less
Trojan Y as a genetic solution for controlling and eradicating the Eastern mosquitofish, Gambusia holbrooki. The project aims to develop applied genetic strategies to eradicate Gambusia, a serious invasive pest fish species, from a Tasmanian estuary. The goal is to advance the Trojan Y chromosome model from theory to an applied solution. The project aims to employ an integrated ecological, physiological, behavioural, genetic and genomics approach, within the unique island-within-an-island status ....Trojan Y as a genetic solution for controlling and eradicating the Eastern mosquitofish, Gambusia holbrooki. The project aims to develop applied genetic strategies to eradicate Gambusia, a serious invasive pest fish species, from a Tasmanian estuary. The goal is to advance the Trojan Y chromosome model from theory to an applied solution. The project aims to employ an integrated ecological, physiological, behavioural, genetic and genomics approach, within the unique island-within-an-island status of Gambusia infestation in Tasmania.Read moreRead less
A pan-genome reverse vaccinology approach to disease prevention in farmed fish. Evolution of new pathogen strains causes major problems in vaccinated animals because these variants can reinfect and cause severe disease in previously protected animals. This project will use state-of-the-art genomics to find new targets that are essential to all strain variants, enabling development of broadly cross-protective vaccines for farmed animals.
What happens to coral reefs without cleaner fish? Marine 'mosquitoes' regularly attack coral reef fish, but are controlled by parasite-eating cleaner fish. Cleaners positively affect reef communities in many ways and this is disproportionate to their tiny size and low density. Their removal for aquarium trades may have staggering effects on reefs. The project will determine how cleaners cause such effects.
Characterisation of vital carbohydrate synthases in pathogenic oomycetes. This project aims to understand the mechanisms that control cell wall stability in the fish pathogen, Saprolegnia parasitica. The biochemical properties and function of vital enzymes involved in cell wall biosynthesis will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology, and structural biology. Next generation ion mobility mass spectrometry will be used to solve challe ....Characterisation of vital carbohydrate synthases in pathogenic oomycetes. This project aims to understand the mechanisms that control cell wall stability in the fish pathogen, Saprolegnia parasitica. The biochemical properties and function of vital enzymes involved in cell wall biosynthesis will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology, and structural biology. Next generation ion mobility mass spectrometry will be used to solve challenging structural questions that cannot be tackled with conventional techniques. Expected outcomes include new knowledge on challenging membrane proteins that allows development of novel strategies for disease control in aquaculture. The data may also be applicable to crop protection from related plant pathogens.Read moreRead less