Expanding the molecular tool set for structural studies of proteins and their complexes. Many applications in medical science and drug development depend on our ability to determine the 3D structures of proteins, protein assemblies and protein-ligand complexes. This project will develop novel lanthanide-binding tags and crosslinking agents that can be coupled to unnatural amino acids introduced into proteins with advanced protein chemistry techniques. These new tools will facilitate the collecti ....Expanding the molecular tool set for structural studies of proteins and their complexes. Many applications in medical science and drug development depend on our ability to determine the 3D structures of proteins, protein assemblies and protein-ligand complexes. This project will develop novel lanthanide-binding tags and crosslinking agents that can be coupled to unnatural amino acids introduced into proteins with advanced protein chemistry techniques. These new tools will facilitate the collection of structure restraints by nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and mass spectrometry, which are needed to generate accurate models of proteins and their complexes with other molecules. Major beneficial outcome will include an increase in the number of protein targets amenable to rational drug design and improved methods for generating new drug leads.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100015
Funder
Australian Research Council
Funding Amount
$405,000.00
Summary
Global positioning system for small molecules: accelerating lead discovery. This project aims to establish a tool to accelerate lead generation from very small molecules. This will shift the paradigm in the identification of small molecules that can serve as lead compounds for the development of specific probes or drugs. This project offers a new strategy to rapidly generate lead compounds from a library of compound fragments. The new approach is expected to facilitate identification and develop ....Global positioning system for small molecules: accelerating lead discovery. This project aims to establish a tool to accelerate lead generation from very small molecules. This will shift the paradigm in the identification of small molecules that can serve as lead compounds for the development of specific probes or drugs. This project offers a new strategy to rapidly generate lead compounds from a library of compound fragments. The new approach is expected to facilitate identification and development of new lead molecules, drawing on advances made in the field of fragment-based lead discovery, which is increasingly used in the pharmaceutical industries. The tools developed can also be applied for imaging of biological processes. By developing new technologies, the project should deliver intellectual property with potential for commercialisation.Read moreRead less
Ultrafast optical non-linearities in robust organometallic materials. This project aims to create organometallic complexes with ultrafast nonlinear optical responses. These robust molecules are intended to be used to prepare surface-supported nanostructures. The project will create materials with reversibly switchable nonlinear optical properties that can control or process incident light beams in photonics technologies. These new materials will have possible applications in future photonics tec ....Ultrafast optical non-linearities in robust organometallic materials. This project aims to create organometallic complexes with ultrafast nonlinear optical responses. These robust molecules are intended to be used to prepare surface-supported nanostructures. The project will create materials with reversibly switchable nonlinear optical properties that can control or process incident light beams in photonics technologies. These new materials will have possible applications in future photonics technologies, potentially creating highly-skilled jobs in Australia and growing Australia’s reputation as a leader in molecular materials science.Read moreRead less