The grand challenge of predicting human movement energetics. This Project aims to advance our understanding of how the neuromuscular system uses energy during movement by exploring the interplay of different factors that influence movement energetics. The Project will explore different levels of organisation; from how muscle fibres consume energy to how those fibres interact and are subsequently controlled within a complex neuromuscular system. Expected outcomes of this Project will be an improv ....The grand challenge of predicting human movement energetics. This Project aims to advance our understanding of how the neuromuscular system uses energy during movement by exploring the interplay of different factors that influence movement energetics. The Project will explore different levels of organisation; from how muscle fibres consume energy to how those fibres interact and are subsequently controlled within a complex neuromuscular system. Expected outcomes of this Project will be an improved capacity to predict energy expenditure of the vast array of movements that humans perform. This will enable accurate monitoring of human energy expenditure and will provide benefits for individualised exercise prescription, enhancing work productivity or designing devices to augment human performance.Read moreRead less
Femoral microarchitecture, strength and locomotion in adult people. This project aims at unravelling the load bearing capacity of human femora microarchitecture. The project will quantify the relationship between geometry, microarchitecture, strain and strength in adult people during normal and accidental motor tasks using micro-computed-tomography images, motion data, supercomputing technology and multivariate statistic. It will benefit the design of novel implantable devices, enhance exercise ....Femoral microarchitecture, strength and locomotion in adult people. This project aims at unravelling the load bearing capacity of human femora microarchitecture. The project will quantify the relationship between geometry, microarchitecture, strain and strength in adult people during normal and accidental motor tasks using micro-computed-tomography images, motion data, supercomputing technology and multivariate statistic. It will benefit the design of novel implantable devices, enhance exercise therapies and diagnostic techniques for promoting hip strength. The project will contribute to the engineering of biological tissue and the development of high-strength and light-weight bio-inspired materials.Read moreRead less
Molecular networks underlying mitochondrial biogenesis in humans. Mitochondria are essential for life, and we propose a highly-innovative approach (employing multiple, cutting-edge ‘omic’ technologies and bioinformatics) to advance the fundamental understanding of how mitochondria respond and adapt to exercise in humans. The project outcomes should include significant new knowledge and advanced expertise that can be used by others to facilitate additional research outcomes. The project anticipa ....Molecular networks underlying mitochondrial biogenesis in humans. Mitochondria are essential for life, and we propose a highly-innovative approach (employing multiple, cutting-edge ‘omic’ technologies and bioinformatics) to advance the fundamental understanding of how mitochondria respond and adapt to exercise in humans. The project outcomes should include significant new knowledge and advanced expertise that can be used by others to facilitate additional research outcomes. The project anticipates the contribution of innovative tools for molecular biology research, benefiting therapeutic and biotechnology applications. This project will support advanced training of young researchers in frontier technologies, which will expand Australian research capabilities and help produce a higher quality workforce.Read moreRead less