Origin and evolution of animal-bacterial symbiosis. This project seeks to understand how interactions between animals and their microbial symbionts – the holobiont – evolved, and how they are influenced by the environment over an animal's life. Using a homegrown Australian model, a sea sponge from the Great Barrier Reef, and advanced multi-omic approaches (genomics plus cell biology), this project aims to uncover the mechanisms underlying the establishment and maintenance of the holobiont throug ....Origin and evolution of animal-bacterial symbiosis. This project seeks to understand how interactions between animals and their microbial symbionts – the holobiont – evolved, and how they are influenced by the environment over an animal's life. Using a homegrown Australian model, a sea sponge from the Great Barrier Reef, and advanced multi-omic approaches (genomics plus cell biology), this project aims to uncover the mechanisms underlying the establishment and maintenance of the holobiont through development, and under changing ecological and environmental conditions. Because of the evolutionary position of sponges, outcomes of this project expect to reveal cardinal rules governing animal-microbe interactions that are fundamental to the health and conservation of most animals and ecosystems.Read moreRead less
How does embryonic physiology shape the divergence of brain development? . Unlike placental mammals (humans, mice, dogs etc) marsupials give birth to very immature young that finalise development in the pouch. Despite this remarkable distinction in the major mammalian lineages, very little is known about how differing reproductive environments impact development and evolution. This project aims to explore how developing inside or outside a uterus impacts brain development in placental vs marsupi ....How does embryonic physiology shape the divergence of brain development? . Unlike placental mammals (humans, mice, dogs etc) marsupials give birth to very immature young that finalise development in the pouch. Despite this remarkable distinction in the major mammalian lineages, very little is known about how differing reproductive environments impact development and evolution. This project aims to explore how developing inside or outside a uterus impacts brain development in placental vs marsupial mammals. Expected outcomes include expanding theories of how different body systems are connected in development and evolution, understanding what aspects of marsupial development might be especially sensitive to variations in environment brought about by climate change and enhancing Australia’s research capabilities.Read moreRead less