Rational Design And Development Of New Anthracenedione Derivatives
Funder
National Health and Medical Research Council
Funding Amount
$471,702.00
Summary
Our laboratory has discovered a way to activate the anti-cancer drug mitoxantrone to make it bind to DNA more effectively. This involves pre-activating it with the simple molecule formaldehyde. This concept has enabled us to design new anticancer drugs that are predicted to be more effective at killing cancer cells. In this study we will synthesise these new compounds then test how effectively they bind to DNA, inhibit growth of tumour cells in culture, and inhibit growth of tumours in mice.
Regulation Of The Androgen Signaling Pathway In Prostate Cancer By MicroRNAs
Funder
National Health and Medical Research Council
Funding Amount
$540,075.00
Summary
Prostate cancer is the most common cancer in men and is dependent upon signaling from male hormones (androgens) for continued growth. We recently identified some novel small RNAs (intracellular messengers), called microRNAs, that are likley to play important roles in maintaining the androgen signaling pathway in prostate cancer. This project will evaluate the functional role of these microRNAs in human prostate cancer, and may provide the foundation for new avenues for therapeutic intervention.