Fractional dynamic models for MRI to probe tissue microstructure. This project aims to develop new mathematical tools for mapping tissue microstructural properties via the use of space-time fractional calculus methods. In magnetic resonance imaging, mathematical models and their parameters play a key role in associating information between images and biology, with the overall aim of producing spatially resolved maps of tissue property variations. However, models which can inform on changes in mi ....Fractional dynamic models for MRI to probe tissue microstructure. This project aims to develop new mathematical tools for mapping tissue microstructural properties via the use of space-time fractional calculus methods. In magnetic resonance imaging, mathematical models and their parameters play a key role in associating information between images and biology, with the overall aim of producing spatially resolved maps of tissue property variations. However, models which can inform on changes in microscale tissue properties are lacking. The tools developed by this project will be used to generate new magnetic resonance image based maps to convey information on tissue microstructure changes in the human brain. Additionally, the mathematical tools developed will be transferable to other applications where diffusion and transport in heterogeneous porous media play a role.Read moreRead less
Multiscale modelling of systems with complex microscale detail. In modern science and engineering many complex systems are described by distinctly different microscale physical models within different regions of space. This project is to develop systematic mathematical and computational methods for the compact and accurate macroscale modelling and computation of such systems for application in industrial research and development. Our sparse simulations, justified with mathematical analysis, use ....Multiscale modelling of systems with complex microscale detail. In modern science and engineering many complex systems are described by distinctly different microscale physical models within different regions of space. This project is to develop systematic mathematical and computational methods for the compact and accurate macroscale modelling and computation of such systems for application in industrial research and development. Our sparse simulations, justified with mathematical analysis, use small bursts of particle/agent simulations, PDEs, or difference equations, to efficiently evaluate macroscale system-level behaviour. The objective is to accurately interface between disparate microscale models and establish provable predictions on how the microscale parameter spaces resolve at the macroscale.Read moreRead less
Multiscale modelling of systems with complex microscale detail. This project aims to develop systematic mathematical and computational methods for the compact and accurate macroscale modelling of systems with microscopic irregular details. The methodology, justified with mathematical analysis and computation, uses small bursts of particle/agent simulations, partial differential equation (PDEs), or difference equations, to efficiently predict macroscale behaviour. This project’s mathematical meth ....Multiscale modelling of systems with complex microscale detail. This project aims to develop systematic mathematical and computational methods for the compact and accurate macroscale modelling of systems with microscopic irregular details. The methodology, justified with mathematical analysis and computation, uses small bursts of particle/agent simulations, partial differential equation (PDEs), or difference equations, to efficiently predict macroscale behaviour. This project’s mathematical methodology aims to efficiently and accurately extract and simulate the collective dynamics which emerge on macroscales, leading to improved prediction and understanding of the significant features of these complex systems at the scale relevant to engineers and scientists.Read moreRead less