Investigating a new way in which diet impacts animal biology. This project aims to investigate the importance of a new way in which diet can alter animal biology. High fat or high sugar diets increase the binding of products of metabolism to chromosomes, which can completely alter the way that DNA is packaged and read. This project will use cell culture, rodent and fly models to identify the regions of the genome that are most affected by the new process. The project will also determine whether ....Investigating a new way in which diet impacts animal biology. This project aims to investigate the importance of a new way in which diet can alter animal biology. High fat or high sugar diets increase the binding of products of metabolism to chromosomes, which can completely alter the way that DNA is packaged and read. This project will use cell culture, rodent and fly models to identify the regions of the genome that are most affected by the new process. The project will also determine whether the cell is harmed, or in fact harnesses the process to control development or metabolism. This project has implications for our understanding of the ways in which genes interact with the environment especially in times of change.Read moreRead less
So Like Your Mum! Is The Health Of Mothers In Far North Queensland Reflected In The Nutrition And Growth Of Their Children In Early Life?
Funder
National Health and Medical Research Council
Funding Amount
$96,631.00
Summary
The health, nutrition and growth of a baby reflect the health and nutrition status of its mother. We will link routine health service information for Indigenous mothers with information on the growth, haemoglobin and health of their young children to identify key factors in a mother’s pregnancy and before, influencing the future health and development of their babies. This study will shape interventions to improve the health of mothers, and thus improve the health of their children through life.
Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
While is important to prevent vitamin D deficiency, controversies exist about optimal vitamin D intakes and concentrations. Our aim is to evaluate safety concerns with dosages of vitamin D which are routinely promoted for unsupervised public use with over the counter products. We will do this by evaluating long-term health effects for infant vitamin D supplementation, and by using a genetic approach to evaluate the causal effects of high vitamin D and calcium concentrations.
Application Of New Technologies And Methods In Nutrition Research – The Example Of Phenotypic Flexibility
Funder
National Health and Medical Research Council
Funding Amount
$210,823.00
Summary
The aim of the Nutritech project is to develop better diagnostics of the effect of foods and dietary supplements on the health of an individual. NutriTech will develop new analytical technologies to comprehensively investigate the diet-health interrelationship and critically assess their usefulness for the future of nutrition research. A new automated method for measuring the effect of diet on multiple measures of DNA damage and nutrients in single cells will be developed at CSIRO.
Interactions Between Diet, Microbiome, Genetics And Epigentics In Determining Risk For Adenomatous Polyps
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
The bacteria that live in the gut interact with the hosts cells and are thought to contribute to causing or preventing diseases, including bowel cancer. We know that diet can change these bacteria populations, but we still do not fully understand how they interact with host cells. The differences in our personal genes are often included in studies of gut bacteria and health and disease. This project aims to consider the role of genes for taste in changing the bacteria and the body’s responses.
Nanoliposomal delivery of docosahexaenoic acid (DHA) to neuronal cells. Omega-3 fatty acids such as docosahexaenoic acid (DHA) are essential for brain function. They are effective as adjunct treatments for depression, but at high doses. The project will develop nanoliposomes to target delivery of DHA to brain cells. Efficient delivery of DHA to brain cells will increase its effectiveness as a dietary supplement and lessen the burden of disease.
Identifying Why Some People Consume Excess Dietary Fat. A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$365,462.00
Summary
Obesity is a significant public health problem, yet some individuals are less susceptible to the development of obesity. High fat eating patterns are commonly associated with overweight/obesity. The taste system is the gatekeeper of digestion and the sense of taste responds to fat, and that the fat taste response is associated with obesity. Using twins as subjects to disentangle the influences of 'nature and nuture', in this project we will identify the mechanisms responsible for linking fat tas ....Obesity is a significant public health problem, yet some individuals are less susceptible to the development of obesity. High fat eating patterns are commonly associated with overweight/obesity. The taste system is the gatekeeper of digestion and the sense of taste responds to fat, and that the fat taste response is associated with obesity. Using twins as subjects to disentangle the influences of 'nature and nuture', in this project we will identify the mechanisms responsible for linking fat taste response to development of obesity.Read moreRead less